Stand up to beat diabetes: new study tests desk hack

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Overweight or obese (body mass index of 25 kg/m2 or higher) 2. Employees with "sedentary" jobs, defined as spending at least 75% of their (8 hours or more) workday sitting at a desk (at home or in an office) 3. Defined as "at-risk" for diabetes, defined as either: 1. Prediabetes (HbA1c of 5.7% to 6.4%) or a fasting glucose of 100 to 125 mg/dL 2. Having one or more additional risk factors: (beyond BMI\>25) * Age 45 years or older * Family history of diabetes mellitus in a first-degree relative * Physical inactivity (no structured exercise activity) * History of gestational diabetes, hypertension, or dyslipidemia * African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, Native Hawaiian, or Pacific Islander ethnicity Exclusion Criteria: 1. Established cardiovascular disease (myocardial infarction, coronary stent, coronary artery bypass grafting, cardiac transplant, or angina) 2. Established congestive heart failure or cardiomyopathy 3. Established peripheral vascular disease 4. Established diabetes (HbA1c ≥ 6.5% or on diabetes medications or insulin) 5. Chronic musculoskeletal disorders involving the lower extremities, such as arthritis of the knees or hips, or regular use of ambulatory assist devices such as a walker or cane 6. Neuropathy of any etiology 7. Positional syncope or history of orthostasis 8. Less than 4 days/week at any single office (or work-from-home) location. 9. Current use of a standing desk for work 10. Tobacco use within the previous 12 months 11. Current illicit drug use or excessive alcohol use (defined as more than 14 drinks/week for women, more than 28 drinks/week for men) 12. Steroid use ≥21 days/year 13. Fasting triglyceride level ≥ 500 mg/dL 14. Thyroid disease 15. Uncontrolled or untreated hypertension(\>150/90 mm Hg) 16. Pregnant or lactating (or plans to become pregnant in the next 6 months) 17. LDL cholesterol ≥ 190mg/dL 18. Currently enrolled or plans to diet or join a weight loss program over the next 6 months. 19. Non-English speaker