Nicotine dependence

This study tests a program called Tabapsy to help people with mental health conditions who smoke. The program includes information meetings, assessments, and workshops on quitting. Researchers will compare it to usual care in 6,500 adults from psychiatric clinics, measuring if th…

Researchers are testing Actívatexto, a mobile program that combines text messages, wearable activity trackers, and nicotine replacement therapy. The trial enrolls Latino adults who smoke at least three days a week, want to quit in the next month, and currently get less than the r…

This study tests whether adding accelerated transcranial magnetic stimulation (aTMS) to the standard smoking-cessation drug varenicline helps adults quit nicotine products like cigarettes and vapes. Thirty participants will take varenicline daily for 12 weeks and receive either r…

This study is testing whether e-cigarettes (nicotine vapes) can help people who are in treatment for substance use disorder quit smoking. Participants will either switch to e-cigarettes or use FDA-approved nicotine patches and lozenges, with weekly counseling. The goal is to see …

This study tests whether the drug varenicline (Chantix) can help veterans who smoke at least 5 cigarettes a day but aren't ready to quit. Participants will either take varenicline or use nicotine lozenges to reduce smoking over 12 weeks. The goal is to see if this approach leads …

This study compares how adult smokers experience IQOS heated tobacco products versus their usual cigarettes. Participants use both products and rate them on appeal, taste, harshness, and satisfaction. Researchers also measure puffing behavior and nicotine withdrawal symptoms. The…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the …

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck, combined with a nicotine patch, can help people stop smoking. Researchers at Mayo Clinic will enroll 150 motivated smokers who smoke at least 10 cigarettes a day. Participants use the d…

This study tests a program called CONNECT Multilingual, designed to help Spanish and Cantonese speakers quit smoking while they undergo lung cancer screening. About 439 current smokers aged 50-80 will receive personalized video doctor messages, text support, and help getting nico…

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This study tests whether changing treatment can help smokers who relapse early after trying to quit. 544 participants who want to quit smoking will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. All visits are remote, and the study lasts 6 mon…

This study tests a mobile app and financial rewards to help veterans quit smoking before major elective surgery. Smoking increases the risk of complications after surgery, but quitting can be hard. The program uses a carbon monoxide monitor and app to verify abstinence, with ince…

This study tests whether offering financial rewards to Alaska Native adults and their family members helps them quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive program or standard support. Success is measured by a saliva test…

This study tests two types of non-invasive brain stimulation (rTMS) to help veterans stop smoking. About 56 veterans who smoke at least 10 cigarettes a day will receive either standard or precision-guided rTMS over three weeks. Researchers will measure how much smoking decreases …

This study tests whether giving smokers a personalized quit plan based on their genes, health history, and biomarkers helps more people stop smoking than standard advice. About 850 smokers and their doctors from primary care clinics will take part. The goal is to see if tailored …

This study is testing whether giving rural smokers a two-week supply of nicotine patches or lozenges can help them quit. Researchers are recruiting 272 adults from rural areas across the U.S. who smoke at least 5 cigarettes daily. The main goal is to see how many people stop usin…

This trial tests whether a digital program called CanCEASE, combined with a health navigator who helps parents address unmet social needs like housing or food, can boost smoking-cessation rates. Around 1,000 parents who smoke and report at least one social risk will be randomly a…

This study tests whether giving adult smokers access to a heated tobacco product (HTP) helps them stop smoking cigarettes. About 1,060 healthy smokers aged 21–65 will use either HTP Device 1 or Device 2 with different stick flavors (tobacco or menthol) for 3 months. The main goal…

This study is testing two counseling approaches—Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE)—to help people on methadone treatment reduce their use of tobacco, opioids, and other drugs. Researchers will enroll 420 adults who are currently on…

This study looks at whether a single 6 mg oral nicotine pouch can lower cigarette cravings and dampen brain activity triggered by smoking-related images. Adults who smoke and are moderately to highly dependent on nicotine will use the pouch after going without nicotine overnight.…

This study tests a smartphone app called ESCAPE, designed specifically for Black adults with HIV who smoke. The app teaches ways to handle stress, anxiety, and nicotine cravings, and is paired with nicotine patches or gum. 300 participants across the US will be randomly assigned …

This study tests whether combining varenicline (a medication that helps people stop smoking) with financial rewards for clean urine samples can reduce alcohol and tobacco use in adults who both drink heavily and smoke daily. Participants are randomly assigned to receive either re…

This study tests whether psilocybin, a psychedelic substance, can help people stop smoking. Sixty-six daily smokers who have tried and failed to quit before will receive either psilocybin or niacin (a vitamin) in two sessions one week apart. Researchers will check if participants…

This study tests a new, non-invasive treatment using low-intensity focused ultrasound (LIFU) to help people quit smoking. It targets deep brain areas linked to nicotine addiction without surgery or needles. The study will enroll 100 adults who have smoked for at least 5 years and…

This study tests a program that combines community health worker visits with a smartphone app to help low-income women stop smoking. About 344 women in Brazil will either get the app plus health worker support or just a referral to a standard quit-smoking clinic. The goal is to s…

This study tests whether a common stop-smoking medication (varenicline) plus financial incentives can help adults aged 18-40 who use both e-cigarettes and cannabis quit vaping. All 105 participants will receive the drug and rewards for 12 weeks. Researchers will also track how ca…

This study is for people who smoke cigarettes but aren't ready to quit. It tests whether giving them a choice of harm-reduction products like e-cigarettes or nicotine pouches helps them smoke less or stop altogether. Participants will use their chosen product for 28 days and be f…

This study tests whether a behavioral sleep intervention combined with the drug varenicline can help heavy smokers quit. Researchers will measure sleep quality, smoking habits, and brain activity in 114 participants. The goal is to see if improving sleep reduces negative emotions…

This study tests whether giving smokers a choice of e-cigarette flavors (tobacco, menthol, mint, or other) helps them stop smoking regular cigarettes. About 1,280 adult smokers will use a provided e-cigarette device for 13 weeks, and researchers will check who stays away from cig…

This study tests whether offering a choice of e-cigarettes, nicotine pouches, or nicotine patches helps people with HIV stop smoking tobacco. About 972 participants in Switzerland will receive their preferred product free for 6 months, plus standard care. The main goal is to see …

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This study is testing a tailored tobacco cessation program for cancer survivors and their caregivers. The program includes four sessions delivered by phone or video, focusing on quitting techniques and support. Researchers want to see how many people enroll and complete the progr…

This study tests a program that combines brief advice, nicotine replacement therapy (like patches or gum), and text-message support to help smoking parents quit. The goal is to reduce children's exposure to secondhand smoke. About 1,200 smoking parents in Hong Kong who live with …

This study tests a simple program for smokers visiting emergency rooms. Participants get a $300 gift card for nicotine replacement products, self-help materials, and six months of phone support from a specialist. The goal is to see if this approach helps more people quit smoking …

This study tests whether adding financial coaching to standard smoking cessation counseling helps low-income smokers quit. 602 participants will receive either standard counseling or integrated financial-smoking counseling, plus nicotine patches. The goal is to see if addressing …

This study tests whether a 5-day course of accelerated deep transcranial magnetic stimulation (aTMS) can help adults aged 18–65 quit smoking. Participants receive 4 brain stimulation sessions per day for 5 days. The main goal is to see if the treatment is tolerable and practical,…

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve o…

This study tests a new way to help people stop smoking by combining standard quit-smoking programs with a computer task that retrains unconscious urges to approach cigarettes. About 300 adults who want to quit will be randomly assigned to one of three groups: standard treatment p…

This study tests whether cannabidiol (CBD), a compound from hemp, can help people who want to quit smoking reduce their cigarette use. 120 adults with tobacco use disorder will receive either CBD or a placebo twice daily for 56 days. Researchers will measure nicotine levels and c…

This study is testing a combination of counseling, peer mentoring, text messages, and nicotine replacement therapy to help people with HIV quit smoking. Researchers will enroll 500 smokers living with HIV in New York City to find the most effective and affordable approach. The go…

This study tests whether varenicline (Chantix), a drug already used to help people quit smoking, can also help them reduce cannabis use. Two hundred adults in South Carolina who smoke cigarettes and use cannabis will receive either varenicline or a placebo, plus counseling. The g…

This study tests whether starting nicotine replacement therapy (patches, gum, or lozenges) at a specific time in the menstrual cycle helps women quit smoking. About 1,200 women who smoke daily and have regular periods will be assigned to start their quit attempt during the follic…

This study tests whether e-cigarettes or nicotine pouches help adult smokers reduce their cigarette use. 256 participants who smoke will be given one of these products for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they smoke a…

This study tests a new program to help people quit smoking by teaching them how to handle withdrawal symptoms and negative feelings. Researchers will enroll 400 adult smokers who want to quit. The goal is to see if this training helps more people stay smoke-free compared to stand…

This study compares three approved smoking cessation products—nicotine replacement therapy (patch plus gum or lozenge), cytisine, and varenicline—combined with coaching and home delivery from a virtual pharmacy. Researchers will track how well 150 Ontario adults who smoke use the…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This study is testing whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in people who smoke daily, have chronic pain, and are on buprenorphine for opioid use disorder. Sixty participants will be randomly assigned to either very low nicoti…

This study tests a proactive approach to help people living with HIV quit smoking. A pharmacist calls participants, offers counseling, and sends cessation medication unless they opt out. The goal is to see if this method works better than standard care. The trial involves 231 adu…

This study tests the VapeAway system, a drug-free program that uses special filters to slowly lower nicotine intake, a sensory tool called the Fix Bar, and digital support to help people stop vaping. About 70 motivated adults who vape daily will use the system for 42 days. Resear…

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This study tests whether the medication varenicline can help adults quit using e-cigarettes. Researchers will compare varenicline to a placebo in 326 people who vape daily. The main goal is to see if more participants can stop vaping for at least a week by the 12-week mark, with …

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This study tests whether nicotine replacement therapy (patches, gum, or lozenges) plus wellness coaching over the phone can help people experiencing homelessness quit smoking. Researchers will enroll 150 adults in San Francisco and Los Angeles who smoke at least 5 cigarettes a da…

This study tests whether nicotine pouches can help smokers reduce their cigarette use. 375 smokers who smoke at least 5 cigarettes a day will be given different strengths and flavors of nicotine pouches to use for 16 weeks. Researchers will measure changes in cigarette smoking an…

This study tests whether using mobile health (mHealth) tools helps find early signs of oral cancer better than the usual visual exam in rural areas of Varanasi, India. Over 5,000 adults with risk factors like smoking, tobacco use, or age over 40 will be screened. The goal is to c…

This trial tests whether proactively connecting household smokers to quit-smoking resources through a child's pediatric care visit increases their use of evidence-based treatments and quit rates. Adult household members who smoke are offered options like nicotine replacement, var…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) to reduce nicotine cravings and vaping. 120 adults who vape heavily will receive either real TI stimulation to deep brain areas linked to addiction or a sham (fake) treatment during a …

Researchers are testing whether a personalized form of transcranial magnetic stimulation (TMS) changes reward-related brain activity more than standard TMS in adults who smoke cigarettes. Participants receive 15 TMS sessions over three weeks, with brain scans used to pick the sti…

Many smokers are not ready to set a quit date, so traditional cessation programs miss them. This trial tests whether counseling focused on practice quitting, where smokers try not smoking for short periods without pressure to quit forever, helps them make a real quit attempt late…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app uses behavioral therapy to help users recognize triggers and build skills to stop vaping. About 1,178 participants will use the app or a control, and research…

This study compares two versions of a smartphone app called Living Free from Tobacco (LiFT) to help young adults ages 18-30 quit using nicotine and tobacco products. About 140 participants will use one of two app versions: one focuses on building mental flexibility to support qui…

This early-stage study at Johns Hopkins is testing whether cannabidiol (CBD) can reduce stress and nicotine withdrawal symptoms in people who smoke. Ninety healthy smokers will receive CBD and then be exposed to stress while researchers measure their mood, heart rate, and stress …

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smok…

This study tests whether a smartphone app called Kick-Nic! can help high school students (ages 13-19) quit vaping. About 306 participants who want to quit will either use the app or visit a standard quit-vaping website for 8 weeks. Researchers will check if they've stopped vaping…

This study tests whether a program that helps people notice and manage smoking triggers can help light smokers (10 or fewer cigarettes per day) quit. About 60 adults will either get standard counseling or counseling plus a cue-based tool where they text about cravings. The goal i…

This study tests whether a personalized approach to smoking cessation helps cancer patients quit. Researchers will use patients' clinical, genetic, and biomarker information to create tailored treatment plans. The study involves 112 participants and compares this precision treatm…

This study tests a social media program called Quit the Hit Toolkit to help teens and young adults stop vaping. Coaches are trained to lead small support groups for 5 weeks. The goal is to see if this approach is practical and helpful for quitting nicotine.

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with overweight or obesity quit smoking. 300 smokers will receive either the drug or a placebo, plus nicotine patches, for 16 weeks. The goal is to see if the drug improves quit rates …

This study tests whether combining text message support with financial incentives helps low-income pregnant women quit smoking more than text messages alone. Thirty pregnant women who smoke will be split into two groups to see which approach is more acceptable and effective. The …

This early-phase study tests whether a device that delivers specific smells can reduce cigarette cravings and help people stop smoking. About 132 smokers will use a smartphone app with or without the scent device for a week, then report cravings and quit attempts. The goal is to …

This study partners with community organizations to adapt a smoking cessation program for adults who smoke and receive care at behavioral health clinics. Researchers will enroll 24 participants to test whether the program is feasible and acceptable. The goal is to learn how to be…

This study tests a behavioral program called QuitVaping, which combines counseling sessions with text message support, to help teenagers aged 14-18 quit vaping. About 400 participants who vape nicotine at least weekly will be randomly assigned to either the QuitVaping program or …

This study is for pregnant people who use tobacco and cannabis and want to quit. Researchers will test a program that helps with depressive symptoms to make quitting easier. The study involves 25 participants and will measure how well the program works and if people stick with it…

This study tests a smartphone chatbot designed to help Black adults quit smoking. The chatbot sends alerts during times when a person is most likely to smoke and suggests ways to handle triggers. 120 participants will be randomly assigned to use the chatbot or not, and researcher…

This study tests a new program where community health workers provide extra support to pregnant women who smoke. The goal is to help them quit smoking during pregnancy. About 105 women in San Bernardino County will take part and receive coaching to stop tobacco use.

This study tests whether yoga can lower tobacco cravings in men aged 18-65 who want to quit. 96 participants will either do low-impact yoga or receive standard quitting advice. Researchers will measure cravings and relapse over three months to see if yoga is a helpful addition.

This study tests whether a personalized exercise program can help smokers who are afraid of bodily sensations (like a racing heart) quit smoking. 360 adults will take part at YMCA locations. The goal is to see if exercise reduces smoking relapse and helps people stay smoke-free f…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 participants in Switzerland and Türkiye will be randomly assigned to the program or a control group. The program includes ei…

This pilot study tests a smartphone app called eMind that delivers an 8-week mindfulness programme to help smokers quit. Researchers want to see if smokers find the app acceptable and easy to use. The study involves 40 adult smokers motivated to quit, who will use the app and pro…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to brain areas involved in craving and self-control. The trial involves 64 smokers who will receive either real or…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study is testing whether a social media and smartphone app program can help teens and young adults who vape to cut back or quit. Participants will be recruited through social media, screened by a chatbot, and given a mobile app with tailored tips and encouragement. The goal …

This study tests whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can help daily smokers quit. rTMS uses magnetic pulses to stimulate brain areas involved in addiction and decision-making. Forty participants will receive daily sessions f…

This study tests whether specific chest exercises can improve breathing, chest expansion, and exercise capacity in university students who smoke. Thirty smokers aged 18-24 will be split into two groups: one doing chest PNF techniques and the other doing chest mobility exercises. …

This study tests whether a non-invasive brain stimulation technique called tDCS can help people who vape nicotine daily to cut back. Forty adults aged 18-65 who vape regularly will receive either real or fake tDCS for 10 sessions over two weeks. Researchers will measure changes i…

This study tests a program designed specifically for Chinese and Korean American smokers who are at high risk for lung cancer. The program includes counseling sessions, family coaching, nicotine replacement therapy (like patches or gum), and information about lung cancer screenin…

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to c…

This study tests whether a dental health evaluation using AI can help people stop smoking. 300 adult smokers who want to quit will get an AI analysis of their mouth and teeth. The main goal is to see if more people have quit smoking after 6 months, confirmed by a breath test.

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is practical and helps veterans stay smoke-free for at least 3 months. About 50 veter…

This study looks at whether a daily dose of kava can help smokers who want to quit. Researchers will check if kava makes it easier to stop smoking, reduces stress, and improves sleep. About 76 adults who smoke at least 5 cigarettes a day and want to quit will take part for 4 mont…

This pilot study is testing whether a high-dose nicotine patch can reduce pain and the need for opioid painkillers in male smokers who are having chest surgery. The patch is given before and after surgery. The study will track how much pain medication participants use. It include…

This study tests whether mindfulness meditation in virtual reality can reduce cigarette cravings and help people quit smoking. Two hundred smokers will be split into two groups: one gets six VR meditation sessions over six weeks, and the other uses nicotine patches and gum. Resea…

This study tests whether a daily oral dose of cannabidiol (CBD) can help people stop smoking tobacco. Fifty adults who smoke more than 10 cigarettes a day and want to quit will take CBD during several practice quit attempts. The goal is to see if CBD increases short-term abstinen…

This study tests whether clavulanic acid, a drug used to boost antibiotics, can help people smoke less. Thirty adult smokers will take either the drug or a placebo for several weeks. Researchers will measure smoking levels and use brain scans to see if the drug changes how the br…

This study tests a digital coaching program that uses a chatbot to help people quit smoking. The program aims to boost motivation, educate about quitting tools, and create a personalized quit plan. Researchers will enroll 440 adult smokers and check if they have quit after 6 mont…

This early-stage study tests a new drug called ATI-1013 in 15 healthy smokers. The drug is an antibody designed to bind to nicotine in the body. The main goal is to check safety and see how long the drug stays in the system. Participants get one IV dose of the drug or a placebo a…

This pilot study tests whether screening and treating sleep disorders during tobacco or cannabis cessation therapy helps people stay abstinent longer. 80 participants will either get usual care or extra sleep-focused care. The study follows them for 6 months to see if addressing …

This study tests a program called Contingency Management that gives Veterans rewards for quitting smoking, verified by breath tests. Researchers will first gather feedback from Veterans and staff, then run a small pilot with 20 Veterans over 5 weeks. If successful, a larger trial…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cravings in people addicted to nicotine. One hundred daily smokers who are highly dependent will receive tDCS sessions. The goal is to see if this painless, mild electrical stimulation can …

This study is developing new MRI techniques to better understand how drug addiction changes the brain. Researchers will scan 1,000 healthy adults, smokers, and drug users to improve imaging methods. The goal is to create tools that can reveal the brain's structure and function in…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers. Researchers will also study how it affects thinking and reward processing in non-smokers. The goal is to understand if blocking a brain c…

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This early-phase study is testing whether cigarettes with very low nicotine content cause less strain on the heart compared to regular cigarettes. Researchers will measure heart rate and heart rate variability in 49 daily and non-daily smokers after smoking different types of res…

This pilot study at Memorial Sloan Kettering tests whether giving cancer patients an indoor air quality monitor helps them maintain a smoke-free home. Ten participants who smoke and are in a tobacco treatment program will use the monitor for about 60 days. Researchers will see if…

This study tests whether community health workers can help more eligible people get screened for lung cancer and quit smoking. The workers will reach out to patients, help them make informed decisions, offer smoking cessation counseling, and navigate barriers to care. The study w…

This study looks at whether oral nicotine pouches (like ZYN) can be a good substitute for cigarettes or smokeless tobacco. Researchers will test different nicotine levels and forms to see which ones reduce cravings and appeal to users. 160 adult tobacco users will try the pouches…

This study will compare how synthetic nicotine and a nicotine analogue (6-methylnicotine) behave in the body versus traditional tobacco-derived nicotine. Twenty-four regular vapers will vape e-liquids containing these substances, and researchers will measure their levels in the b…

This study compares how people use two generations of IQOS heated tobacco devices—the newer IQOS Iluma i and the older IQOS 2.4—and how each affects their smoking behavior and sensory experience. Participants attend two lab visits, use both devices, and have their puffing pattern…

This study recruits 600 adults who want to quit smoking. Participants use a smartphone app to take photos of their environment when they smoke and at random times. Researchers use artificial intelligence to analyze these images and identify environmental triggers that lead to rel…

This study aims to understand why some people respond better to a brain stimulation treatment (rTMS) for smoking. Researchers will measure brain activity in 100 smokers aged 21-60 to see if emotional triggers affect treatment success. The goal is to personalize future therapies f…

This study investigates how flavor (mint vs. fruit) and nicotine strength (2mg vs. 4mg) influence the appeal and abuse liability of oral nicotine gums and pouches. Researchers will recruit 320 young adults aged 21–25 who currently use e-cigarettes exclusively, including a subset …

This study looks at young adults aged 18 to 25 who use both tobacco/nicotine products and cannabis. Researchers want to understand what happens to cannabis use when participants try to quit nicotine. All participants receive remote counseling and incentives to stop using nicotine…

This study looks at how cooling ingredients like WS-3 and menthol in e-cigarettes affect how much people like them and find them addictive. Researchers will have 66 adult e-cigarette users try different e-liquid mixtures and report their feelings of liking, craving, and harshness…

This study looks at how smoking little cigars affects levels of harmful chemicals called oxidants in the body. Researchers will compare three types of smoking: high-oxidant little cigars, low-oxidant little cigars, and regular cigarettes. Fifty daily smokers will provide breath, …

This study aims to find the smallest amount of nicotine that smokers find rewarding or addictive. Researchers will test different nicotine doses in 45 adult smokers to see which dose they can identify and prefer. The goal is to better understand how addiction develops, which coul…

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study looks at how romantic partners who both smoke can support each other when trying to quit. Researchers will ask 250 couples to fill out daily surveys for two weeks while attempting to quit, tracking their smoking, cravings, and stress. The goal is to understand which ty…

This study looks at how the body handles synthetic nicotine compared to natural nicotine from tobacco. Eighteen experienced e-cigarette users will vape three different nicotine blends in a controlled setting. Researchers will measure nicotine levels in the blood, heart effects, c…

This study tests a program that combines help with quitting smoking and getting a lung cancer screening (a special CT scan) for African American smokers. The goal is to reduce the high rate of lung cancer in this group. About 250 people will take part, and researchers will track …

This study recruits 300 young adults aged 18-24 who smoke cigarillos to understand how different flavors influence their smoking behavior and perceptions. Researchers will measure puff counts and self-reported rewards from smoking, and simulate how changing flavor availability mi…

This study tests whether combining neurofeedback with integrative body-mind training can change brain function and reduce cravings and substance use in adults who regularly use alcohol, cannabis, and cigarettes. Researchers will use brain scans to measure changes in connectivity …

This study uses brain scans (fMRI) to see what happens in the brain just before a smoker lapses (takes a cigarette during a quit attempt). Researchers will have 150 smokers complete a task where they can delay smoking for money, while their brain activity and feelings are measure…

This study aims to understand what makes it easier or harder for African American smokers to use a smartphone app designed to help them quit. Researchers will first get feedback from a small group to improve the app, then test it with 30 people who want to quit. The app sends rem…

This study looks at how the drug propranolol and nicotine patches, alone or together, change brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers will undergo brain scans while viewing these cues. The goal is to understand the brain mechanisms b…

This study looks at how THC, the active part of cannabis, changes people's desire for e-cigarettes and their body's response. Researchers will give different doses of THC to 100 adults who use both e-cigarettes and cannabis, then measure how much they vape, their cravings, heart …

This study looks at how difficult childhood experiences might change brain function and make people more likely to start smoking. Researchers will give a small dose of nicotine or a placebo to 150 nonsmoking young adults aged 18-21, then use brain scans and questionnaires to meas…

This study looks at whether virtual reality (VR) can measure how smokers pay attention to smoking-related cues, which may help understand nicotine addiction. Two hundred daily smokers will take either a medication (varenicline) or a placebo, and their eye movements and cravings w…

This study looks at whether e-cigarettes or oral nicotine pouches can help people who smoke cigarettes cut down or switch completely. Two hundred adult smokers who have tried to quit before will be randomly assigned to use one of these products instead of cigarettes for six weeks…

This study looks at how daily vapers and cigarette smokers experience withdrawal when they stop using nicotine for 24 hours. Researchers will measure mood, cravings, attention, and other symptoms in 370 participants. The goal is to better understand nicotine dependence and help d…

This study looks at whether Native American adults who smoke can lower their risk of chronic pain by quitting smoking for 4 weeks. Researchers will measure pain sensitivity and other health markers before and after a stop-smoking program. The goal is to see if this approach is fe…

This study looks at how the amount of nicotine and the pH level in nicotine pouches influence how appealing and addictive they feel to young adult users. Researchers will have 84 participants try different pouches and rate their experience. The goal is to help regulators understa…

This study at Johns Hopkins University is testing nicotine pouches (like Zyn) in 120 adults—60 regular smokers and 60 people who rarely use nicotine. Participants will use the pouches in two lab sessions while researchers measure how much nicotine gets into the blood, how appeali…

This study looks at whether the flavor of e-cigarettes helps smokers switch from regular cigarettes. 210 smokers who have tried to quit before will use fruit, tobacco, or menthol flavored e-cigarettes for 6 weeks. Researchers will track how many cigarettes they smoke and how sati…

This study looks at how THC, the active part of cannabis, affects cigarette cravings and smoking habits. Researchers will give 100 adults who smoke both tobacco and cannabis different doses of THC or a placebo, then measure how many cigarette puffs they take and how they feel. Th…

This study looks at what happens when people who regularly use both marijuana and tobacco use them together. Researchers will measure how much THC and nicotine get into the blood and how the body responds. The goal is to better understand the health effects of using both substanc…

This study enrolls 40 healthy smokers to compare how addictive five new oral nicotine products are compared to their usual cigarettes and Nicorette gum. Participants will use each product in a clinic setting, and researchers will measure their feelings of liking and nicotine leve…

This study tests whether the drug cytisinicline changes how the brain reacts to seeing smoking-related images in daily smokers who are not trying to quit. Sixty-four participants will receive either the drug or a placebo and undergo brain scans while watching videos of smoking an…

This study looks at how quitting smoking temporarily increases pain in people with chronic pain, and how the brain processes this. Researchers will use brain scans and daily reports from 132 smokers—some with chronic back pain, some without—to understand these changes. The goal i…

This study tests whether a non-invasive brain stimulation technique called TMS can change how the brain processes rewards in smokers. Researchers will compare different targeting methods to see which best boosts brain signals related to reward and decision-making. The goal is to …

This study tests different patterns of transcranial magnetic stimulation (TMS) on the brain's reward center in 42 nicotine-dependent smokers. Researchers measure changes in brain waves and decision-making to find which pulse protocol works best. The goal is to identify the most e…

This study tests whether very low nicotine little cigars change how people smoke and affect their lungs compared to regular cigars. About 50 adult little cigar smokers will attend three 4-hour visits at Ohio State University. They will fill surveys, give blood, do breathing tests…