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Childhood hardship may rewire brain for nicotine risk

NCT ID NCT05665465

First seen Apr 06, 2026 · Last updated May 24, 2026 · Updated 7 times

Summary

This study looks at how tough childhood experiences change brain function and reactions to nicotine in 150 non-smoking young adults aged 18-21. Participants receive a tiny dose of nicotine or a placebo nasal spray, then answer questions and have brain scans. The goal is to understand why some people are more likely to start smoking, not to treat or cure any condition.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Duke University Medical Center

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.