New study lets smokers choose their own path to quit
NCT ID NCT07199517
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is for people who smoke cigarettes but aren't ready to quit. It tests whether giving them a choice of harm-reduction products like e-cigarettes or nicotine pouches helps them smoke less or stop altogether. Participants will use their chosen product for 28 days and be followed for 6 months to see if they cut down or quit smoking.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- e-cigarettes, nicotine pouches, nicotine patches, and nicotine lozenges
- What this could lead to
- If successful, this approach could help smokers who aren't ready to quit reduce their cigarette use or even stop smoking entirely.
- What could go wrong
- This is a behavioral study, not a drug trial, so results may vary widely. Participants might not stick with the products, and long-term health effects of e-cigarettes or nicotine pouches are still uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 472 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Jul 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Able to communicate fluently in English (i.e., speaking, writing, and reading) 2. Male and female smokers who are \> 21 years of age and self-report smoking at least 5 cigarettes (menthol and/or non-menthol) per day for at least the last 6 months. 3. Have a carbon monoxide (CO) greater than or equal to 10 ppm 4. Not using any forms of nicotine regularly other than cigarettes. 5. Not interested in quitting smoking in the next 30 days. 6. Capable of giving written informed consent, including compliance with the requirements and restrictions listed in the combined consent and HIPAA form Exclusion Criteria: Smoking Behavior 1. Regular use of nicotine-containing products other than cigarettes (e.g., chewing tobacco, snuff, snus, cigars, e-cigs, IQOS, ONPS, etc.). 2. Current or impending (during the study period) enrollment or plans to enroll in a smoking cessation program. 3. Current use of smoking cessation medication. 4. Provide a CO breath test reading less than 10 ppm at Intake. Alcohol and Drug 1. History of substance abuse (other than nicotine dependence) in the past 12 months. 2. Current alcohol consumption that exceeds 20 standard drinks/week. 3. Current use of recreational drugs (other than nicotine and cannabis) Medical 1. Women, including all individuals assigned as "female" at birth, who are pregnant, breastfeeding, or planning a pregnancy over the duration of the study period. 2. Serious or unstable disease within the past year (e.g. cancer, uncontrolled hypertension, cardiovascular event). Psychiatric 1\. Lifetime history of schizophrenia or psychosis. General Exclusion 1. Past, current, anticipated, or pending enrollment in another research program over the study period that could potentially impact subject safety, study data, and/or the study design as determined by the Principal Investigator. 2. Any medical condition, illness, disorder, adverse event (AE), or concomitant medication that could compromise participant safety or significantly impact study performance as determined by the Principal Investigator. Subjects may be deemed ineligible for any of the aforementioned reasons at any point throughout the study, as well as during the initial telephone screen. 3. Significant non-compliance with protocol and/or study design as determined by the Principal Investigator and/o. Subjects may be deemed ineligible at any point throughout the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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