Brain zapping study seeks optimal pulse to curb smoking cravings
NCT ID NCT06695884
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests different patterns of transcranial magnetic stimulation (TMS) on the brain's reward center in 42 nicotine-dependent smokers. Researchers measure changes in brain waves and decision-making to find which pulse protocol works best. The goal is to identify the most effective TMS approach for future treatments of nicotine addiction.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Transcranial Magnetic Stimulation (TMS)
- What this could lead to
- If successful, this could identify the most effective TMS pulse pattern to reduce cravings and improve decision-making in smokers, paving the way for better treatments.
- What could go wrong
- This is a small, early-stage study with only 42 participants. It measures brain signals, not actual smoking behavior, so results may not translate to real-world quitting success.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 42 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2024
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Nicotine dependent individuals (according to the Alcohol, Smoking and Substance Involvement Screening Test nicotine dependence score). 2. Be between the ages of 18 and 55 years old. 3. Not received substance abuse treatment within the previous 30 days. 4. Be in stable mental and physical health. 5. If female, test non-pregnant. 6. No evidence of focal or diffuse brain lesion on MRI. 7. Be willing to provide informed consent. 8. Be able to comply with protocol requirements and likely to complete all study procedures. Exclusion Criteria: 1. Contraindication to MRI (e.g., presence of metal in the skull, orbits or intracranial cavity, claustrophobia). 2. Contraindication to rTMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \> 15 minutes, implanted electronic device, metal in the head, or pregnancy). 3. History of autoimmune, endocrine, viral, or vascular disorder affecting the brain. 4. History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment. 5. Life time history of mental disorders such as: Bipolar Affective disorder (BPAD), Schizophrenia, Post-traumatic Stress disorder (PTSD) or Dementia or Major Depression. 6. uninterruptable central nervous system medication
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Rutgers University - Newark
RECRUITINGNewark, New Jersey, 07102, United States
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