Hypertensive disorder

This study tests a program for new mothers who had high blood pressure during pregnancy. Participants wear a FitBit and receive weekly messages with personalized activity goals. The goal is to see if this approach increases daily steps and improves blood pressure, and whether mom…

Researchers are testing whether a standardized automated blood pressure measurement protocol in Australian general practice clinics improves hypertension control among adults. The protocol uses a validated device that takes several readings automatically after a five-minute rest,…

This study tests whether using a 21-question tool to understand a person's daily habits, then giving tailored advice, can lower blood pressure more than routine counseling. Researchers will compare two groups of adults with hypertension over three months. The goal is to see if pe…

This study explores whether measuring a hormone called renin can help doctors choose the best first medication for people with early-stage high blood pressure. Adults with low renin levels are randomly assigned to receive either spironolactone or a standard blood pressure drug fo…

Researchers test whether a digital care pathway app plus non-real-time messaging with a nurse helps adults in primary care lower their systolic blood pressure. About 600 patients with uncontrolled hypertension receive usual care, usual care plus the app, or usual care plus the ap…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This 52-week trial tests whether combining a structured lifestyle program with a mushroom-based supplement and the drug bupropion helps overweight adults lose weight and lower cardiometabolic risk. About 250 adults aged 18 to 55 with a BMI between 25 and 35 will be randomly assig…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests whether a nurse-led, community-based program can help lower blood pressure in adults aged 25 and older with uncontrolled hypertension in Monrovia, Liberia. Trained community health nurses provide medication and lifestyle counseling at mobile clinics in high-traff…

This trial tests whether giving adolescent girls a daily multiple micronutrient supplement (with or without extra nutrients) improves their growth, brain function, bone health, and overall well-being compared to the standard weekly iron-folic acid pill. About 3,000 girls aged 10–…

This study tests whether medically tailored meals, prepared to support kidney and heart health, can improve blood pressure and kidney function in Veterans with chronic kidney disease. About 100 participants will be randomly assigned to receive these meals or usual care for three …

This trial tests whether a granule form of the Chinese herbal formula Huayu Jiedu (FTFY-919) works as well as the traditional decoction for people with acute hypertensive intracerebral hemorrhage, a type of stroke caused by bleeding in the brain. About 300 adults who have had a b…

This trial tests whether empagliflozin, a drug used for diabetes, improves blood vessel and nerve function in adults aged 45 to 75 with prehypertension. Participants take the drug or a placebo for two weeks, then switch, while a control group with normal blood pressure is observe…

This study will look at how well a drug called ARNi (sacubitril/valsartan) lowers blood pressure in 500 adults with hypertension in the United Arab Emirates. Researchers will compare it to standard treatments like ACE inhibitors and calcium channel blockers. The goal is to see if…

This study tests an experimental drug called HRS-1780 in people with uncontrolled or resistant hypertension—high blood pressure that stays high despite treatment. The trial compares three different doses of HRS-1780 against a placebo to see if it safely lowers blood pressure. Par…

This pilot study is testing whether a Bifidobacterium probiotic supplement can help lower blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks, and researchers will monitor their blood pressure and other he…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This trial tests whether combining nurse-delivered care with text message check-ins and support can help adults with uncontrolled high blood pressure lower their blood pressure and improve diabetes management. Participants receive either usual care or the enhanced support, which …

This trial tests a 12-week community program for older stroke survivors who also have high blood pressure or type 2 diabetes. Participants take part in physical activities like exercise and nutrition education, plus cognitive games on an AI-enabled large screen. The goal is to se…

This trial tests whether a team-based care program, initiated in the emergency department, can help adults with severely elevated blood pressure achieve better control. Participants are randomly assigned to either the team-based program or usual care. The team-based program inclu…

This phase 3 trial tests a procedure called renal denervation, where a small amount of alcohol is injected around the kidney nerves to calm overactive signals that raise blood pressure. 142 people with uncontrolled hypertension will either get the real procedure or a sham (fake) …

This trial compares two ways of managing high blood pressure: using a cuffless wearable device that tracks blood pressure continuously for 24 hours versus traditional office measurements. About 3,000 adults with high blood pressure will be randomly assigned to one of the two stra…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This trial tests whether a low-sodium diet can improve blood pressure control in people who had a hypertensive disorder of pregnancy. Participants receive either a provided diet with less than 2000 mg of sodium per day or a standard diet with no salt restrictions for the first we…

This pilot study tests a 6-session lifestyle program for people with high blood pressure, where each participant brings a supportive partner. The program covers heart-healthy habits like diet, exercise, stress management, and sleep, along with communication skills to help partner…

This pilot trial is testing a smartphone app that acts like a personal coach to help adults with uncontrolled high blood pressure improve their self-care. The app provides education and interactive coaching to encourage medication adherence and healthy habits. The study will enro…

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This trial is testing two experimental versions of a blood pressure drug, called D311 and D107, against the original medication, CKD-339. Healthy adults aged 19 to 55 will receive a single dose of each version in a random order to compare how the drug is absorbed and processed in…

This study looks at whether giving people with high blood pressure and food insecurity $100 a month for fruits and vegetables can improve their health. It focuses on Native Hawaiian and Pacific Islander adults in Hawaii. Some participants will also get one-on-one help from a comm…

This trial tests whether a 3-month dietary program, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure in Chinese adults with hypertension. About 800 participants from workplace canteens will either receive standard hypertension care or also get specially…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This trial tests whether a telemedicine program can help Black patients with high blood pressure get better control. The program includes home blood pressure monitoring, medication management, and support from pharmacists, nurses, community health workers, and social workers. Res…

This study tests a drug called 2-HOBA in 20 adults with salt-sensitive high blood pressure. The drug aims to calm overactive immune cells that may worsen blood pressure when salt is eaten. Researchers will measure blood pressure changes and blood vessel health after taking 2-HOBA…

This study tests a program to help people with HIV who also have high blood pressure stick to their medication. Participants will get educational materials, a home blood pressure monitor, and regular check-ins with a nurse. The goal is to see if this approach is practical and hel…

People living with HIV have twice the risk of heart attacks and stroke compared to the general population. This trial tests whether integrating clinical pharmacists into HIV care can improve blood pressure control and reduce cardiovascular disease risk. The study enrolls 450 adul…

This study investigates whether Songling Xuemaikang capsules, a traditional Chinese herbal formula, can help people with both high blood pressure (hypertension) and insomnia. About 260 adults aged 18–79 with mild hypertension and sleep difficulties will take either the herbal cap…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This study tests a multilevel care model designed to help low-income adults with hard-to-control hypertension. The model combines patient education, electronic health record alerts for providers, and support from community health workers. Researchers will measure changes in blood…

This study explores whether virtual group medical appointments focused on lifestyle changes can help people with high blood pressure lower their readings. Participants attend four online sessions over eight weeks, track their blood pressure at home, and get medication adjustments…

This Phase 3 trial tests a new drug called TCA108 for adults with uncontrolled hypertension (high blood pressure). About 400 participants who are already on two blood pressure medications will receive either TCA108 or other standard treatments for 10 weeks. The main goal is to se…

This study tests whether a new drug called baxdrostat can lower blood pressure in Chinese adults whose hypertension remains uncontrolled despite taking two or more blood pressure medications. Participants receive either baxdrostat or a placebo daily for 12 weeks, while continuing…

This study tests whether adding an 8-week online mindfulness program, called Mindfulness in Motion, to usual care helps people with high blood pressure improve their blood pressure, weight, stress, sleep, and well-being. Participants will be randomly assigned to either the mindfu…

This study tests whether combining two medications, empagliflozin and finerenone, can lower blood pressure in adults with obesity and stage 1 hypertension. Participants take the drugs or a placebo daily for 12 weeks. The trial also measures effects on kidney function, inflammatio…

This phase 3 trial tests whether a new drug called HCP1803-4 can safely lower blood pressure in adults with essential hypertension. Participants are randomly assigned to receive either the new drug or a control drug. The study measures changes in sitting blood pressure over time …

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This pilot study tests a new device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. Twenty adults with untreated mild hypertension will either get the real procedure or a sham (fake) one. The main goal is to see if the real t…

This pilot study tests whether a connected blood pressure monitor, supervised daily by a healthcare assistant, helps patients with blood cancers like CLL or lymphoma stick to home monitoring. The goal is to catch and manage high blood pressure early, a common side effect of BTK i…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study tests a mobile app called TansiyoRitim for people with high blood pressure. The app provides educational videos, texts, and reminders to help users control their blood pressure, take their medication as prescribed, and feel more confident in managing their condition. R…

This Phase 3 trial tests whether adding baxdrostat (Baxfendy) to standard care can improve heart structure and function in 286 adults with high blood pressure and thickened heart walls. Participants take either baxdrostat or a placebo daily for 12 months, with heart scans and reg…

This study will test whether measuring blood pressure at home and having weekly phone meetings with a pharmacist can help control high blood pressure. About 420 adults from two emergency department clinics will take part. Half will use the home monitoring and telehealth program f…

This Phase 2 trial tests whether a fixed-dose combination of leucine, sildenafil, and metformin (NS-0200) can lower blood pressure in adults aged 18 to 75 with hypertension. About 150 participants receive one of two doses of the combination or a placebo for 12 weeks. The main goa…

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the dru…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This study looks at whether eating all meals within an 8-hour window earlier in the day can improve heart health in adults aged 60 and older who have high blood pressure and often skip breakfast. Over 12 weeks, participants will either follow this eating schedule or stick to thei…

This study tests a liquid herbal supplement called DBPS in 198 adults with prehypertension (blood pressure slightly above normal). Participants will take the supplement or a placebo daily for 4 weeks. The goal is to see if the supplement can lower blood pressure and help prevent …

This pilot study in Colombia will test whether a nursing program that tailors education and counseling to each patient's needs can help people with high blood pressure or type 2 diabetes stick to their medications and achieve better disease control. About 100 to 200 adults alread…

This study gives 400 adults with diabetes or high blood pressure free home-delivered produce boxes and vouchers for 6 months, plus nutrition education and self-management classes. The goal is to see if this helps them eat more fruits and vegetables, feel less food insecure, and i…

This study tests whether combining a Bluetooth blood pressure monitor with regular support from a community health worker can help Black women control high blood pressure after pregnancy. About 404 women will be randomly assigned to either this extra support or standard care. The…

This early-stage study tests a new tablet called HS-10522 in healthy Chinese adults and those with mild hypertension. The main goal is to check safety and how the drug moves through the body. 88 participants will receive either the drug or a placebo to compare side effects and dr…

This pilot study tests a special pacemaker-like device called Moderato Plus in 20 people with high blood pressure and a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The device delivers Cardiac Neuromodulation Therapy to help control blood pressur…

This study tests whether the drug propranolol can prevent heart injury after breast cancer surgery in women who also have high blood pressure or angina. One hundred participants will either receive propranolol before surgery or standard care. Researchers will measure heart stress…

This study looks at whether setting a pacemaker to a personalized rate of 75 beats per minute, instead of the usual 50-60, can improve heart function and blood flow to the brain in people with high blood pressure and a slow heart rate. About 70 patients aged 65 and older will be …

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests whether covered stents are better than bare metal stents for people with narrowed kidney arteries caused by atherosclerosis. About 150 participants will be randomly assigned to one stent type and followed for 12 months to see changes in kidney function and blood …

This small pilot study will test a pharmacist-led program to control high blood pressure and cholesterol in 10 people aged 50-75 who carry the APOE ε4 gene, a major risk factor for Alzheimer's. Participants will take specific medications for six months to see if managing these he…

This study tests whether a device that temporarily restricts blood flow to the arms (remote ischemic conditioning) can help lower blood pressure in people with hypertension who moved to high-altitude areas. 184 adults will either continue their usual medication or add the device …

This early-stage study tests a single injection of a new drug, IBI3016, in 30 Chinese adults with mild to moderate hypertension who are not currently on blood pressure medication. The main goal is to check safety and how the drug moves through the body, with a secondary look at i…

This study tests whether a clinical decision support tool, embedded in electronic medical records, helps doctors prescribe more effective blood pressure medications. About 168 adults with uncontrolled hypertension will be enrolled. The main goal is to see if the tool leads to low…

This study will give 150 children and teens with high blood pressure, high cholesterol, or obesity a free debit card to buy fruits and vegetables, plus virtual nutrition classes. The goal is to see if this program helps improve their heart health over 6 to 12 months. Participants…

This study looks at whether a program called HEARTS can help people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part, and clinics will either use the HEARTS program or continue their usual care. The program includes tr…

This study tests whether a 12-month digital program with health coaching and a wearable device can reduce scarring in the heart muscle caused by high blood pressure. Researchers will enroll 200 adults aged 40-70 with early signs of heart thickening. The goal is to see if lifestyl…

This study tests a new way of managing care for older adults (ages 60-74) who have both high blood pressure and type 2 diabetes. About 960 people from rural community health centers will either receive the new integrated care package or continue with standard care. The goal is to…

This study tests whether a daily black seed extract supplement (Nisatol®) can help lower blood pressure in women with borderline high readings or a specific nighttime blood pressure pattern. 106 women will take either the supplement or a placebo for 12 weeks. Researchers will mea…

This study tests a 3-week online lifestyle program for adults aged 60-75 with high blood pressure. The program focuses on healthy eating, exercise, stress management, sleep, social support, and avoiding risky substances. Researchers will measure changes in blood pressure, quality…

This study tests whether taking a vitamin B3-like supplement (nicotinamide riboside) combined with brisk walking twice a week can lower blood pressure in post-menopausal women with early-stage hypertension. 112 women will be randomly assigned to one of four groups: supplement plu…

This study tests a procedure that uses radiofrequency energy to disable certain nerves near the kidneys and abdomen. The goal is to see if this can safely lower blood pressure and improve blood sugar control in 20 adults with resistant hypertension and type 2 diabetes who have no…

This study tests a 12-month community program to help adults with high blood pressure in Bangladesh. The program includes group classes, one-on-one coaching, and tools like blood pressure monitors and reminder calendars. Researchers will compare blood pressure changes in 480 peop…

This study tests a 12-week program that combines a healthy diet, exercise, sleep, and stress management with a careful plan to reduce blood pressure medication. The goal is to see if people with high blood pressure can stop taking their pills and keep their blood pressure normal.…

This study tests whether regular phone counseling can help adults with high blood pressure improve their self-care, such as taking medication correctly, eating well, and exercising. About 320 patients from teaching hospitals in Ethiopia will either receive usual care or get 10-15…

This pilot study tests a device called the Netrod renal denervation system in 20 adults with uncontrolled high blood pressure who are not taking blood pressure pills. The device uses radiofrequency energy to calm overactive kidney nerves, which may help lower blood pressure. Rese…

This study tests a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys, to see if it can safely lower diastolic blood pressure (the bottom number) in people with isolated diastolic hypertension. About 124 adults who have never taken bloo…

This study tests a 6-week program designed for people with high blood pressure who have low health literacy. Participants attend group sessions and get phone coaching to learn how to manage their condition. The goal is to see if this approach can lower blood pressure better than …

This study tests an experimental drug called IBI3016 in people with mild to moderate high blood pressure. Participants receive either the drug or a placebo as an injection every 3 or 6 months for up to 2 years. The goal is to see if the drug safely lowers blood pressure better th…

This study expands a successful blood pressure program to 50 primary health centers across five Nigerian states. Over 10,000 adults with high blood pressure will receive simplified care from trained non-physician health workers, following the WHO HEARTS package. The goal is to im…

This study tests a new drug called VCT220 in 160 adults with high blood pressure who are also overweight or obese. Participants will take either VCT220 or a placebo pill for 20 weeks. The main goal is to see if VCT220 can safely lower blood pressure more than a placebo.

This study will test whether giving primary care doctors easy-to-read reports from patients' Fitbits helps them counsel patients with high blood pressure to be more active. About 330 patients and their doctors will take part. The goal is to see if this simple, low-cost approach c…

This early study tests a device that targets specific kidney nerves to lower blood pressure. About 15 adults with high blood pressure who cannot take or tolerate standard medications will receive the procedure. The goal is to see if it is safe and can reduce blood pressure for up…

This study looks at whether squeezing a handgrip device or walking is better at lowering blood pressure in people with high blood pressure. About 99 adults with stage 1 hypertension will be assigned to one of the two exercises. The goal is to see which activity leads to a greater…

This early-stage trial will test two experimental drugs, AD-2321 and AD-2322, in 41 healthy adults to see how they interact in the body. The study focuses on safety and how the drugs are processed, not on treating high blood pressure. Results will guide future studies in patients…

This study tests whether a mobile app can help people with high blood pressure better manage their condition. 40 adults with hypertension will use either a Bluetooth-connected blood pressure monitor that sends readings to an app, or a standard monitor. The goal is to see if the a…

This study tests whether an AI-powered app called 'Smart family doctor' can help people who have had heart surgery (bypass or stent) better control their blood pressure, blood sugar, and cholesterol. About 951 participants from 10-20 hospitals will use the app for personalized he…

This study tests whether a 'smart' blood test can help doctors choose the right blood pressure medication for each person. High blood pressure affects 1 in 3 adults and can lead to strokes or heart attacks. The trial will enroll 400 people across Europe to see if this personalize…

This study tests two progestin-only birth control pills—drospirenone and norethindrone—to see which one helps control high blood pressure after a pregnancy complicated by preeclampsia. Fifty women will take one of the pills daily for six weeks after leaving the hospital. The goal…

This study tests whether Songling Xuemaikang capsules can help control cerebral small vessel disease (CSVD), a condition where small blood vessels in the brain get damaged over time, often linked to high blood pressure. Researchers will enroll 90 adults aged 55-75 with hypertensi…

This study tests a drug called osilodrostat in 63 adults with Cushing's syndrome and high blood pressure. The goal is to see if it can safely lower blood pressure by reducing cortisol levels. Participants will take the drug or a placebo for 30 weeks, with doses adjusted based on …

This study tests whether a workplace-based program can help adults aged 18-60 who are newly diagnosed with high blood pressure. Over 500 participants will either receive the special program or standard workplace health management. The goal is to see if the program improves blood …

This study tests whether choosing blood pressure medication based on a person's specific heart and blood vessel measurements (hemodynamic phenotyping) works better than the usual guideline-based approach. About 240 adults with mild-to-moderate hypertension who have never taken bl…

This study compares a newer blood pressure drug, sacubitril/allisartan, to the standard drug amlodipine in 104 overweight or obese adults with high blood pressure. Participants will take one of the two drugs for 8 weeks, with dose adjustments if needed. The main goal is to see wh…

This pilot study tests whether a non-invasive brain stimulation technique called temporal interference can safely help regulate blood pressure. Researchers will enroll 25 adults with either mild untreated hypertension or hard-to-treat hypertension, as well as people with low bloo…

This early-stage trial tests a single injection of SHR-4658 in 48 healthy volunteers and people with slightly high blood pressure. The main goal is to check safety and how the body processes the drug. If it passes safety checks, it may lead to larger studies for heart failure tre…

This study will test a new way to manage heart disease risk using a digital, nurse-led remote monitoring program. About 750 adults with heart conditions will use home devices and answer questionnaires. The goal is to see if this approach helps more patients reach their cholestero…

This study looks at whether combining the Mediterranean diet with intermittent fasting can lower blood pressure in people newly diagnosed with hypertension. Researchers will enroll 48 adults aged 40-65 with high blood pressure and a healthy weight. Participants will receive nutri…

This study tests whether using a potassium-enriched salt substitute (75% regular salt, 25% potassium chloride) instead of regular table salt can help control blood pressure in kidney transplant recipients. About 80 participants will use either the special salt or regular salt at …

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This early-stage trial will test a new drug called QLS1410 in 78 healthy adults and people with mild high blood pressure. The main goal is to check safety and how the body processes the drug. Researchers will also look at how food affects the drug and whether it lowers blood pres…

This trial tests whether a Huawei smartwatch can measure blood pressure accurately with fewer readings than the standard 24-hour monitor, which inflates a cuff every 15 to 30 minutes and often disrupts sleep. About 500 adults in Malaysia will participate, with a subgroup of 50 un…

This study tests whether a Huawei smartwatch can accurately identify adults at risk for hypertension (high blood pressure) in everyday settings. About 500 adults in Malaysia will wear the smartwatch, which uses light sensors to estimate blood pressure. A subgroup of about 50 peop…

This study tests a new, contactless camera technology that measures heart rate, blood pressure, and heart disease risk from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults aged 30 and older in Jakarta. If accurate, this …

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This trial tests whether a school-based program called Operation ToneUp can improve fitness, nutrition knowledge, and blood pressure in children in grades 3 through 6. Students in participating schools will complete two 20-minute web-based sessions each week during class time, fo…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This trial tests whether pairing women who had high blood pressure during or after pregnancy with a trained community health worker for six months can lower their blood pressure compared to usual care. Participants are randomly assigned to receive either standard care or standard…

This trial asks whether stopping alcohol for 8 weeks can improve blood pressure and other heart health markers in adults aged 26 to 49 who drink heavily and have high blood pressure. Participants are randomly assigned to either abstain from alcohol or continue their usual drinkin…

This trial tests whether eplerenone, a drug that blocks the hormone aldosterone, can prevent the onset of high blood pressure in people aged 30–55 who have a mild, early form of primary aldosteronism but normal blood pressure. Participants will receive either eplerenone or a plac…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

This study will test whether a 12-week Transcendental Meditation (TM) program can improve stress, mood, and blood pressure in post-menopausal women at risk for hypertension. Sixty women aged 50-80 with mildly elevated blood pressure and stress will be randomly assigned to TM or a…

This study tests whether notifying obstetric clinicians when a pregnant patient is at high risk for preeclampsia increases the use of low-dose aspirin, which can help prevent the condition. Researchers will compare clinics that receive these alerts to those that continue usual ca…

This study tests whether using portable air cleaners and other indoor air quality measures can lower the risk of heart disease in older adults (ages 55-79) living in Montana, where wildfires are common. Participants will use air cleaning devices at home, and researchers will trac…

This study tests whether a higher dose of aspirin (150mg) is better than the usual dose (75mg) at preventing preeclampsia, a serious condition involving high blood pressure during pregnancy. The trial will include 86 pregnant women in Kathmandu who are at high risk based on a sco…

This phase 2 trial tests whether potassium magnesium citrate, a supplement that provides key nutrients from the DASH diet, can lower blood pressure in African Americans with pre- or stage 1 hypertension. The study will enroll 45 participants and measure blood pressure over 24 hou…

Researchers are testing whether older adults with high blood pressure who report insomnia can improve their sleep by pressing six acupoints on themselves each night for 28 days. The trial compares this self-acupressure routine with sleep hygiene training in 94 participants aged 6…

Researchers are testing whether a structured prenatal education program based on the Roy Adaptation Model can reduce stress and improve quality of life for pregnant women with hypertensive disorders. The study enrolls 54 pregnant women between 20 and 32 weeks of gestation who hav…

This study tests whether using a lower-sodium dialysis fluid can improve blood pressure and blood vessel function in people with kidney failure on hemodialysis. Twenty-five participants will each receive both a low-sodium and a standard-sodium dialysis for three weeks, in random …

This study looks at how a cannabis-based drug (Dronabinol) affects blood pressure and heart function. Researchers will measure blood pressure, heart rate, and nerve activity in 50 healthy adults aged 21-40 who use cannabis occasionally. The goal is to see if cannabis can help man…

This pilot study tests whether adding regular sauna sessions to usual care can help lower blood pressure in people with primary aldosteronism, a condition that causes high blood pressure. Ten adults will attend three 30-minute sauna sessions per week for two weeks while wearing a…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18-65. The goal is to find a non-drug way to help manage blood pressure during…

This study tests whether a common water pill (furosemide) can help women with severe preeclampsia recover faster after childbirth and leave the hospital sooner. About 186 women will receive either furosemide or a placebo starting 12 hours after delivery. The goal is to see if the…

This study tests whether a short, supervised handgrip exercise program is practical and enjoyable for older adults (65+) with high blood pressure. Thirty participants will do handgrip exercises twice a week for 4 weeks. Researchers will check if the program is easy to stick with …

This study tests whether a virtual reality (VR) program that combines special sounds, lights, and real-time body feedback can lower stress and improve heart health markers in 40 adults visiting a cardiology clinic. Participants will be randomly assigned to VR, a non-VR relaxation…

This study compares two blood pressure medications, amlodipine and a purer version called levamlodipine, to see which causes less ankle swelling in post-menopausal women. About 344 women aged 50-79 with mild to moderate high blood pressure will take a daily pill for 18 weeks. Doc…

This study will test whether a single dose of beetroot juice can improve blood pressure and heart rate recovery after light cycling in adults with type 2 diabetes. About 20 participants aged 40-65 will receive either beetroot juice or a placebo in random order. The goal is to see…

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study looks at whether listening to music can help lower anxiety in people having surgery for the first time. Researchers will measure heart rate, blood pressure, and anxiety levels in 90 adults. Some will choose their own music, others will listen to a standard playlist, an…

This study tests whether listening to music for 20 minutes before a wrist fracture reduction can lower pain and stress. 192 adults will be randomly assigned to hear their favorite music, a therapist-chosen song, or no music. Researchers will measure pain scores, heart rate, and b…

This study tests whether a physical activity program can improve health and well-being in midlife Hispanic women who have elevated blood pressure and are going through menopause. Forty sedentary women aged 45-50 will take part. The goal is to see if the program increases physical…

This study tests whether tension and trauma releasing exercises (TRE) can improve quality of life and sleep in 40 adults aged 50-65 with stage 1 hypertension. Participants will do supervised TRE sessions for 8 weeks. Researchers will measure changes in sleep quality and well-bein…

This study looks at how drinking coffee or hibiscus tea affects blood pressure and heart rate during long periods of sitting. Thirty healthy adults (15 men, 15 women) will try both drinks on different days. Researchers will measure their heart health before and after sitting for …

This early-stage trial is asking whether two medications—one for blood pressure and one for cholesterol—can be safely taken together without affecting how each works. Healthy adult volunteers will receive each drug alone and then both together, so researchers can compare drug lev…

This study will screen over 7,000 adults aged 40+ living in affordable housing in New York City for undiagnosed high blood pressure and glaucoma. Participants who need follow-up care will be randomly assigned to receive text message reminders or usual care. The goal is to see if …

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study uses imaging scans to measure the size and blood flow speed in three key arteries—the carotid, renal, and femoral—in adults with high blood pressure. The goal is to see how hypertension affects these blood vessels, both structurally and functionally. By comparing measu…

This study looks at how anticipated stigma and illness identity affect quality of life in men with hypogonadism (low testosterone). It compares these men to those with other chronic endocrine conditions like diabetes, hypothyroidism, or hypertension. The goal is to see if these p…

This study reviews existing research to understand how aldosterone, a hormone that regulates blood pressure, contributes to hypertension. It looks at the proteins and genetic factors involved in aldosterone production and how the body's signals might be able to block its effects.…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study investigates whether erectile dysfunction (ED) in men being treated for high blood pressure is linked to a hidden heart condition called subendocardial ischemia, where the heart muscle doesn't get enough oxygen. Researchers will compare a noninvasive heart test called …

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study tests a new wearable system called M2VS that measures heart activity (ECG) and blood pressure continuously for 24 hours. Researchers want to see if it works as well as standard monitors like Holter ECG and ambulatory blood pressure monitors. The study involves 20 adult…

This study tests whether blood pressure readings taken over different layers of clothing are as reliable as those taken on bare skin. Researchers will compare measurements from 161 emergency department patients. The goal is to see if clothing affects accuracy, which could change …

This small pilot study will test two common blood pressure medicines—nicardipine and sodium nitroprusside—in 12 patients with acute respiratory failure and high blood pressure. Researchers will use a special imaging technique called electrical impedance tomography to see how thes…

This study tests whether a large language model (LLM) — a type of AI — can help village doctors make better care plans for patients with type 2 diabetes and high blood pressure. About 20 rural doctors will review standardized patient cases, with half receiving AI-assisted decisio…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study will follow 100 adults whose high blood pressure remains high despite taking at least two medications. Over three months, researchers will track changes in blood pressure and other health markers to find patterns that could help identify which patients might respond be…

This study will check blood pressure and ask about health habits in 500 adults who attend free public health screenings in Croatia. Researchers want to see how many people have high blood pressure, how many know they have it, and how many are taking medicine for it. No treatments…

This study looks at how metabolic health (measured by a simple blood test) relates to artery stiffness and daily blood pressure changes in 800 adults. Researchers will use routine tests and non-invasive measurements to find better ways to identify people at higher risk for heart …

This early-stage trial will test a new tablet that combines two common drugs—one for type 2 diabetes and one for high blood pressure—in healthy volunteers. The goal is to see if the single pill works the same in the body as taking the two drugs separately. Thirty-six healthy adul…

This study compares three methods of measuring pulse wave velocity, a key indicator of artery stiffness that helps predict heart risk. Researchers will enroll 350 adults with high or uncontrolled blood pressure. Participants will have measurements taken with a neck-and-groin sens…

This early-stage study will test a new experimental drug called AD-231 in 60 healthy adults. The goal is to see how safe the drug is and how the body processes it, not to treat any disease. Participants will receive a single dose of the drug and have their blood levels measured o…

This study follows 2,500 adults in Mexico aged 18 to 65 who do not yet have type 2 diabetes or high blood pressure. Over five years, researchers will track their health through yearly check-ups, blood tests, and lifestyle questionnaires. The goal is to identify what factors incre…

This study in Côte d'Ivoire tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves child and maternal health. About 1,040 mothers will either receive the cash incentive or just educational materia…

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study will measure the thickness of the carotid artery wall in 100 adults on hemodialysis. The goal is to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to artery thickness. No new t…

Stanford University is enrolling 50 adults aged 18–64 to collect vital signs using a blood pressure cuff, EKG, and PPG. The goal is to use this data to develop a noninvasive, continuous blood pressure monitoring device that could replace traditional cuffs. This is an observationa…

This study tests whether giving primary care doctors detailed feedback on how well they follow treatment guidelines can improve care for patients with high blood pressure and type 2 diabetes. Researchers will enroll 324 healthcare providers in Nepal, Mozambique, Tanzania, and Chi…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study works with 35 primary care clinics to help them screen patients for physical inactivity and refer them to community-based exercise programs. The goal is to see if this approach can be smoothly integrated into routine care and whether it leads to better health outcomes …

This study looks at 40 mothers and their 6-month-old babies to see if mindfulness training during pregnancy helps them handle stress better together. Researchers will measure heart rate and stress responses during a short separation-and-reunion task. They will then check if these…

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This pilot study looks at how the diabetes and weight-loss drugs semaglutide and tirzepatide directly affect blood vessels and heart function, beyond their known effects on weight. Researchers will infuse the drugs into the arm or bloodstream of 112 volunteers with different body…

This study looks at how a 12-week cardiac rehabilitation exercise program affects the heart and blood proteins in 42 older adults with high blood pressure who don't exercise regularly. Participants will be randomly assigned to either the exercise program or a control group that r…

This study looks at how genes influence heart hormones called natriuretic peptides, which help control blood pressure and metabolism. Researchers will give 200 adults with mild high blood pressure low-salt and high-salt diets, plus a saline infusion, to see how their blood pressu…

This pilot study will test whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The study will enroll 60 people, including those with resistant hypertension, untre…

This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is …

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study follows 400 adults with primary hyperparathyroidism who are scheduled for parathyroid surgery. Researchers will measure aldosterone, a hormone that helps control blood pressure, before surgery and at 3, 6, and 12 months after. They will also track blood pressure and us…

This study looks at how a specially prepared liquid blood pressure medicine (nicardipine) works in 30 children aged 1-15 who have both cancer and high blood pressure. Researchers will take small blood samples to measure how the medicine moves through the body. The goal is to find…

This study looks at how two different exercise programs affect a protein called Sestrin-2, which is linked to inflammation and metabolism, in women with obesity and high blood pressure. About 42 women aged 30-65 will do either moderate steady exercise or brisk interval exercise f…

This early-stage trial will test a new drug called QLS1410 in 12 healthy Chinese adults to see if eating affects how the body absorbs it. Participants will take the drug once with food and once without, and researchers will measure drug levels in their blood. The results will hel…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This early-stage study will test three experimental drugs (AD-231A, AD-231B, and AD-231C) in 55 healthy adults to see how they interact in the body and if they are safe. The drugs are being developed for high blood pressure and high cholesterol. Participants must be between 19 an…

This study aims to create an AI system that combines Traditional Chinese Medicine (TCM) body type data with modern technology to give personalized health advice. Researchers will enroll 195 adults who have all three conditions: high blood pressure, high blood sugar, and high chol…

This study will follow 120 pregnant women with high blood pressure or preeclampsia to see if certain ultrasound scans and blood tests can predict who will develop severe disease. Researchers will measure blood flow in the mother's heart, eyes, and womb, along with lung ultrasound…

This study will see if community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. About 300 adults who are medically underserved will work with a CHW to create a personal hea…

This study tests how stimulating the vagus nerve at different frequencies affects heart rate, blood pressure, and breathing in 36 healthy adults. Participants will receive five different stimulation frequencies (including a sham) in random order. The goal is to find which frequen…

This study examines whether two types of blood pressure medications, ACEIs and ARBs, can reduce the chance of developing pneumonia after a stroke. Researchers will analyze medical records from over 13,600 patients with both stroke and high blood pressure. The goal is to see if th…

This study tests a computer tool that helps doctors and cancer survivors decide together on the best heart-protective medications and tests. Researchers will enroll 60 cancer survivors at risk for heart problems. The goal is to see if the tool is easy to use and helps people foll…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study looks at whether the natural drop in blood pressure during sleep (called 'dipping') is linked to changes in the heart's electrical activity in people with high blood pressure. Researchers will monitor 140 adults using a 24-hour blood pressure device and compare those w…

This study will test a new wrist-worn device called the Hilo band that measures blood pressure continuously over 24 hours. About 330 adults with high blood pressure will wear the Hilo band along with a standard arm cuff monitor and a chest sensor. The goal is to see how well the …