Can a higher dose of aspirin prevent a dangerous pregnancy complication?
NCT ID NCT07373756
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a higher dose of aspirin (150mg) is better than the usual dose (75mg) at preventing preeclampsia, a serious condition involving high blood pressure during pregnancy. The trial will include 86 pregnant women in Kathmandu who are at high risk based on a scoring system. Participants will take aspirin daily from enrollment until delivery, and doctors will monitor for signs of preeclampsia.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Aspirin
- What this could lead to
- If successful, this could show that a higher dose of aspirin (150mg) is more effective than the standard 75mg at preventing preeclampsia in high-risk pregnancies.
- What could go wrong
- This is a small, single-center trial (86 participants) that hasn't started recruiting yet. Results may not apply to all populations, and aspirin carries risks like bleeding or allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 86 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * • All pregnant women with Gestosis score of 3 or more who consents for the study and aged 18 years and above. Exclusion Criteria: * • Known hypersensitivity to aspirin, uncontrolled asthma with NSAID sensitivity * Bleeding disorders, platelet dysfunction, thrombocytopenia, anticoagulant use, active peptic ulcer, history of GI bleed, severe hepatic/ renal disease
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.