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Exercise may unlock heart health secrets for seniors with hypertension

NCT ID NCT06247774

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a 12-week cardiac rehabilitation exercise program affects the heart and blood proteins in 42 older adults with high blood pressure who don't exercise regularly. Participants will be randomly assigned to either the exercise program or a control group that receives regular phone calls. Researchers will measure heart structure, physical function, and protein levels to find clues about how exercise might reduce heart failure risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cardiac rehabilitation exercise program
What this could lead to
If successful, this could identify specific proteins that explain how exercise reduces heart failure risk, potentially leading to targeted therapies or personalized exercise plans.
What could go wrong
This is a small, early-stage study with only 42 participants, so results may not apply to everyone. It focuses on measuring proteins, not directly testing a treatment, so it won't prove that exercise prevents heart failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 42 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Hypertension (controlled on stable medication regimen) * Structural heart abnormality (LVH or LA enlargement) * LVEF \> 50% * Sedentary * BMI \<30 Exclusion Criteria: * Diabetes * Unable to exercise * Supplemental oxygen use * Pulmonary hypertension * Sleep apnea * Regular exercise training * Devices that limit ability to achieve target heart rate * Moderate to severe valve disease * Recent (within 3 months) major CV event or planned procedures (within 6 months) * Terminal illness, life expectancy \<6 months * Inability or unwillingness to comply with study requirements * No access to smart phone/tablet

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac rehabilitation Exercise training Hypertension Proteomics

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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Other studies related to the condition(s) this trial covers.