Insel Gruppe Ag, University Hospital Bern

This study looks at whether taking a mix of probiotics (good bacteria) can change the gut microbiome of children and teens aged 5-18 with inflammatory bowel disease (IBD). About 40 participants will be randomly assigned to take probiotics or a placebo, then switch after a period.…

This study looks at whether removing the entire pancreas is better than removing just part of it for people with certain cancers in the head of the pancreas who are at high risk of complications. The main goal is to see if total removal helps patients live longer without hurting …

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This study tests a minimally invasive laser treatment for glioblastoma that regrows shortly after initial surgery, before standard radiotherapy and chemotherapy begin. The goal is to see if the laser can safely treat the regrowth without delaying the planned follow-up treatments.…

This phase 2 trial is testing whether adding a procedure called radiofrequency ablation (bRFA) to standard chemotherapy and immunotherapy is safe for people with bile duct cancer that cannot be removed by surgery. About 36 participants will be randomly assigned to receive either …

This study tests a new approach for people with atrial fibrillation who have just received a coronary stent. Instead of taking multiple blood thinners together for months, the experimental group takes only one antiplatelet drug for the first month, then switches to a single antic…

This study tests whether doing specific core muscle exercises right after abdominal surgery can lower the chance of developing an incisional hernia and reduce long-term pain. About 588 adults having abdominal surgery will be randomly assigned to either standard care or a daily ex…

This study tests whether the drug landiolol can safely keep heart rate below 90 beats per minute during major surgery in 114 patients with heart risks. The goal is to see if this approach is feasible and might reduce heart injury after surgery. Participants receive the drug throu…

This study looks at 320 adults who had a brain bleed (subarachnoid hemorrhage) to see if the type of IV fluid they receive affects their recovery. The goal is to find out if a fluid with a specific salt content can reduce dangerous complications like blood vessel spasms and brain…

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. The balloon is inserted through the leg and inflated to block blood flow below the chest, potentially sending more blood to the heart and b…

This study looks at how well a higher dose (8mg) of the drug Aflibercept (Eylea) works in the first two months for people with wet age-related macular degeneration, a leading cause of vision loss. Researchers will track fluid changes in the retina and vision improvements in 50 pa…

This study tests whether adding high-dose steroids to standard aspirin treatment helps children recover better from a stroke caused by inflamed brain arteries. About 70 children aged 6 months to 18 years will be randomly assigned to receive either steroids plus aspirin or aspirin…

This study tests a patient-centred program to help older adults (65+) reduce or stop using sleeping pills like benzodiazepines. The program includes a tapering plan, educational materials, and cognitive behavioural therapy tools. Researchers will track whether participants can cu…

This study tests whether a risk-score algorithm can safely personalize how long patients take dual antiplatelet therapy (two blood thinners) after getting a heart stent. About 2,788 participants will be assigned to either algorithm-guided or standard treatment duration. The goal …

This study tests a new type of PET/CT scan (AzaFol) to see if it can better diagnose giant cell arteritis, a condition that causes inflamed blood vessels. About 70 people with suspected GCA will get the new scan and a standard scan to compare accuracy. The goal is to improve diag…

This study compares a newer MRI contrast agent, gadopiclenol, with the standard agent, gadobutrol, for imaging the kidneys and adrenal glands. About 104 adults with incidental findings on scans will receive one of the two agents during a single MRI session. The goal is to see if …

This study tests whether adding a specific laparoscopic stitch (McCall suture) during a routine hysterectomy can prevent the top of the vagina from dropping later on (pelvic organ prolapse). About 114 women having a laparoscopic hysterectomy for non-prolapse reasons will be rando…

This study tests whether an eHealth app can help parents of children under 6 reduce their kids' exposure to second-hand smoke. About 160 families will use the app or receive standard care. The goal is to lower children's urine cotinine levels and prevent asthma and other diseases…

This study compares two long-acting drugs, indapamide and chlorthalidone, to the standard short-acting drug hydrochlorothiazide for preventing calcium kidney stones. About 99 adults who have had at least two kidney stones in the past 10 years will participate. The goal is to see …

This study tests whether an eHealth app that coaches parents can help lower the energy balance in children aged 2-6 who are already above the 97th BMI percentile. About 148 families will be randomly assigned to use the app or receive standard care. The goal is to see if the app c…

This study tests whether starting a structured exercise and education program within a month of a pulmonary embolism (a blood clot in the lungs) can prevent long-term problems like poor quality of life, shortness of breath, and reduced physical ability. About 160 hospitalized pat…

This small pilot study tests whether a special rocking bed (Somnomat Casa) can improve sleep quality in people with Parkinson's disease. Fifteen participants will use the bed at home for two months, and researchers will measure how acceptable and helpful the treatment is. The goa…

This study tests a new type of deep brain stimulation called 'Burst-DBS' for people with long-term facial pain or pain after a stroke. Twenty adults will have electrodes placed in the thalamus (a pain-related brain area) and try both standard and burst stimulation patterns. The g…

This study tests whether removing the chest tube on the same day as minor lung surgery is safe. About 304 adults having small lung or chest lining biopsies will be randomly assigned to have their tube removed early or stay overnight. The goal is to see if early removal reduces co…

This study tests whether using a tiny ultrasound camera inside the heart during ablation can reduce or replace X-rays. Ablation uses catheters to fix abnormal heart rhythms, and X-rays are normally used to guide them. Half of the 70 participants will get the ultrasound-guided pro…

This study tests whether hormone replacement therapy (HRT) or cognitive behavioral therapy (CBT-I) can help perimenopausal women sleep better. Fifty-four women with insomnia and hot flashes will receive either HRT, weekly CBT-I sessions, or sleep hygiene tips for 8 weeks. Researc…

This study tests a mobile app called Mio-App designed to help children and teenagers with cancer improve their thinking, memory, and motor skills. The app includes cognitive and physical exercises along with questions to boost self-awareness. Researchers will enroll 40 participan…

This study tests whether adding a mild electrical stimulation to the skin of the affected hand (called SAES) can improve hand function in children aged 6-18 with hemiparesis (one-sided weakness) due to cerebral palsy or stroke. 34 participants will be randomly assigned to receive…

This study tests whether a midazolam nasal spray can quickly reduce acute anxiety in adults receiving palliative care. Participants will receive one of two doses of midazolam or a placebo spray. The main goal is to see if anxiety levels drop within 30 minutes, while also checking…

This study tests a program called Mio-Training for 40 children aged 8–16 with ADHD. The training combines memory exercises, coordination tasks, and questions to improve self-awareness and thinking skills. Researchers will measure changes in metacognitive awareness and executive f…

This study is collecting health data from 1,500 adults with diabetes in Switzerland to see how well current treatments work in everyday life. Researchers will track complications, quality of life, and survival over time. The goal is to find out what's working and what needs impro…

This study looks at small molecules called miRNAs in the blood of patients with septic shock. The goal is to understand why some patients develop a weakened immune system after sepsis, which can lead to more infections and higher risk of death. Researchers will compare miRNA patt…

This study tests whether computer analysis of speech can reliably detect motor, emotional, and cognitive changes in people with Parkinson's disease. Researchers will record speech from 80 patients while they are on and off medication or deep brain stimulation. The goal is to find…

This study looks at whether adults with glycogen storage disease type I (GSDI) can safely include more fructose and galactose in their diet. Currently, patients must avoid these sugars, which limits food choices. Researchers will give 20 adults either fructose alone or fructose p…

This study is a registry that will enroll 816 adults with coronary artery disease. It compares two types of heart scans—CCTA and OCT—to see which one better identifies dangerous plaque and helps doctors plan treatment. The goal is to improve diagnosis and long-term outcomes, not …

This study tests whether a structured shared decision-making process helps patients with severe aortic stenosis choose between two valve replacement options: TAVR (less invasive) and SAVR (surgery). 140 patients aged 70+ will be randomly assigned to either the structured approach…

This study looks at adults aged 18-70 who have a specific type of broken back (thoracolumbar burst fracture) but no nerve damage. Half will get surgery to fuse the spine, and half will wear a brace for six weeks instead. Researchers want to see if avoiding surgery works just as w…

This study looks at two ways to check for blocked heart arteries in people with severe aortic stenosis who are getting a new heart valve (TAVI). One method is the usual invasive X-ray test; the other uses non-invasive risk management. The goal is to see which approach leads to be…

This study looks at 200 adults with rectal cancer who had chemoradiotherapy and then chose organ-preserving treatment. Some had a small local surgery to remove the scar, while others did not. Researchers will compare bowel, bladder, and sexual function between the two groups over…

This study looks at why some stroke survivors develop long-term pain called central poststroke pain (CPP). Researchers will use brain scans to see how brain connections change in people with CPP. The goal is to better understand what causes this pain, which could lead to better t…

This study tests a questionnaire called QUOCCAS that parents and children fill out to see if it can spot kids with a higher chance of having an inherited cancer syndrome. About 205 children and teens with cancer will take part, giving a blood or saliva sample for genetic testing.…

This study tests different ways to stimulate the brain during surgery to monitor motor function while minimizing patient movement. Researchers will use accelerometers and microscope video to measure movement. The goal is to make brain surgery safer by protecting areas that contro…

This study looks at whether low levels of immunoglobulin G (IgG), a type of antibody, are linked to fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue scores and infection rates between MS patients with low IgG and those with normal IgG. The goal is …

This study is working to make magnetic resonance spectroscopy (MRS) more sensitive and reliable for measuring natural chemicals in the body. Researchers will test new scanning methods in about 100 healthy volunteers, including during sleep or after exercise. The goal is to create…

This study tests whether a brain mapping technique called navigated transcranial magnetic stimulation (nTMS) can help doctors plan radiation therapy better for people with brain metastases near the motor cortex. About 30 patients who had surgery for a brain tumor will get both a …

This study looks at two ways to teach medical residents how to use a special ultrasound technique (VExUS) to check for fluid overload in patients with acute heart failure. About 23 residents will be trained either in-person or remotely, and their ultrasound skills will be compare…

This study looks at people with small intestinal neuroendocrine tumors that have spread and cannot be cured. It compares those who had surgery to remove the main tumor plus other treatments against those who had only other treatments. The goal is to see if surgery helps patients …

This study follows 329 adults who need surgery for an infection after a hip, knee, or other joint replacement. Researchers will track which treatments—surgery and antibiotics—lead to the best outcomes. The goal is to find patterns that help cure infections more reliably and impro…

This study looks at whether a new digital education and self-management program is practical and helpful for people with fibrotic interstitial lung disease. About 80 participants will use the program on their phone or computer during rehab or clinic visits. Researchers will measu…

This study will observe 40,000 adults undergoing anesthesia across Europe to track any problems that occur with airway management, such as difficulties with breathing tubes or masks. Researchers will record patient details and how anesthesia is given, then analyze any incidents t…

This early-stage study looks at how two common blood thinners, rivaroxaban and apixaban, behave in people with compensated liver cirrhosis. 24 participants receive a single dose of one drug, and researchers measure drug levels and blood clotting markers over 12 hours. The goal is…

This study compares brain aging in 200 healthy volunteers and people with multiple sclerosis using advanced MRI scans. Researchers aim to find patterns that predict how quickly the brain ages in MS. Participants undergo MRI and clinical assessments, but no treatment is given.

This study looks at whether surgery can help people whose glioblastoma has come back after initial treatment. 120 participants will be randomly assigned to either have surgery followed by second-line therapy, or to have second-line therapy alone. The goal is to see if surgery imp…

This study tests whether injecting a small amount of salt water into the space around the lung during a CT-guided lung biopsy can lower the chance of a pneumothorax (collapsed lung). Researchers will also position patients so the biopsy targets gravity-dependent areas. About 198 …

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and pain. The goal is to identify genetic factors that could help predic…

This study looks at how a person's genes and other factors influence pain after surgery. Researchers will follow 5,000 adults having planned operations to see which genetic variations are linked to pain levels and painkiller use. The goal is to better understand and personalize p…

This study is tracking 2000 adults who are having weight-loss (bariatric) surgery to learn what factors influence their pain and daily functioning afterward. Researchers will use patient questionnaires to measure pain, side effects, and long-term recovery. The goal is to better u…

This observational study follows 400 women aged 40-60 to compare respiratory infection rates between those taking hormone replacement therapy (HRT) and those not. Participants wear a smartwatch to track vital signs and report symptoms for six months. The goal is to understand if …

This study will follow 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Some were taking blood thinners when they had their stroke, others were not. Researchers want to understand why blood thinners fail in some patients, by looking at …

This study tests whether a structured communication protocol called StOP? helps surgical teams talk more clearly during operations. Researchers will compare death rates and other outcomes in 400 patients whose surgeons use the tool versus those who don't. The goal is to see if be…