Insel Gruppe Ag, University Hospital Bern

This study looks at whether the type of intravenous (IV) fluid given to patients with a subarachnoid hemorrhage (a type of brain bleed) affects their recovery. The researchers want to see if a fluid with a different salt content can reduce dangerous complications like brain spasm…

This study tests whether a short-acting beta-blocker called landiolol can keep heart rate below 90 beats per minute during and after major surgery in people with heart risks. About 114 adults aged 45 and older with at least two risk factors (like high blood pressure or heart dise…

This study tests whether adding high-dose steroids to standard aspirin treatment helps children aged 6 months to 18 years recover better from a stroke caused by inflamed brain arteries. About 70 children across 20+ hospitals will be randomly assigned to receive either steroids pl…

This study tests a new approach for people with atrial fibrillation (an irregular heartbeat) who receive a heart stent. Instead of taking multiple blood thinners together for months, participants will take just one drug at a time: an antiplatelet for the first month, then a diffe…

This study tests whether closing a small heart pouch (left atrial appendage) with a device, along with continuing blood thinners, can reduce the risk of another stroke in people with atrial fibrillation who already had a stroke while on blood thinners. About 482 participants will…

This study looks at whether removing the entire pancreas is better than removing just part of it for people with certain cancers in the head of the pancreas. The goal is to see if total removal helps patients live longer without making their quality of life worse. The trial invol…

This study tests whether a personalized risk-score algorithm can better determine how long patients should take two blood thinners after getting a heart stent. About 2,788 adults receiving a drug-coated stent will be assigned to either algorithm-guided or standard treatment durat…

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. About 98 adults who have a cardiac arrest in the hospital will take part. The goal is to see if the balloon leads to a sustained heartbeat …

This study is enrolling 816 adults with coronary artery disease to compare two imaging techniques: a non-invasive CT scan (CCTA) and an invasive camera placed inside the heart arteries (OCT). The goal is to see how well the CT scan can identify dangerous plaque and guide treatmen…

This study tests a new type of PET/CT scan using a tracer called AzaFol to see if it can better diagnose giant cell arteritis (GCA), a condition that causes inflamed blood vessels. About 70 people aged 50 or older with suspected GCA will receive one AzaFol-PET/CT scan. The result…

This study compares a newer MRI contrast agent, gadopiclenol, to the standard agent, gadobutrol, to see if it works just as well for imaging the kidneys and adrenal glands. About 104 adults with incidental findings in these organs will be randomly assigned to receive one of the t…

This study compares two long-acting diuretics (indapamide and chlorthalidone) to a standard short-acting one (hydrochlorothiazide) for preventing calcium kidney stones. About 99 adults who have had at least two kidney stones in the last 10 years will participate. The goal is to s…

This study tests whether a smartphone app can help parents reduce their young children's exposure to second-hand smoke. About 160 children under 6 who live with a smoking parent will take part. The goal is to lower the children's urine cotinine levels, a marker of smoke exposure,…

This study tests whether a smartphone app that coaches parents can help prevent obesity in children who already have a high body mass index (BMI). About 148 families will take part, with parents using the app to improve their child's diet and activity. The goal is to see if the a…

This study compares two treatments for insomnia in perimenopausal women: hormone replacement therapy (HRT) and cognitive behavioral therapy (CBT-I). 54 women with hot flashes and poor sleep will receive either HRT, weekly CBT sessions, or basic sleep tips for 8 weeks. The goal is…

This study tests a mobile app (Mio-App) designed to help children and teens aged 8-16 who have or had cancer. The app combines thinking exercises and physical tasks to boost metacognitive awareness and reduce long-term cognitive and physical problems. About 40 participants will u…

This study tests if using a tiny ultrasound camera inside the heart during ablation for ventricular arrhythmias can reduce the need for X-rays. About 70 adults with premature ventricular contractions or ventricular tachycardia will be randomly assigned to receive ablation with or…

This study tests whether a nasal spray containing midazolam can quickly reduce sudden anxiety in adults receiving palliative care. About 36 participants will receive either a low dose, a higher dose, or a placebo spray. Researchers will measure anxiety levels before and 30 minute…

This study tests whether adding a gentle electrical stimulation glove to standard therapy can improve hand and arm function in children with hemiparesis (weakness on one side). 34 children aged 6-18 will either receive the glove therapy plus usual care, or usual care alone, for 5…

This study looks at whether it is safe to remove chest tubes on the same day as minor lung surgery. Currently, tubes stay in for at least 24 hours, which can slow recovery. The trial will compare patients who get their tube removed early to those who follow standard care, checkin…

This study tests whether starting a structured exercise and education program soon after a hospital stay for a pulmonary embolism (a blood clot in the lungs) can improve quality of life and reduce long-term symptoms like shortness of breath. About 160 high-risk adults will be ran…

This study tests a patient-centered program to help adults aged 65 and older reduce their use of sleeping pills like benzodiazepines. The goal is to improve safety and sleep quality by addressing the challenges of stopping these medications. About 470 participants will take part …

This study tests a new way to stimulate the brain (called Burst-DBS) to see if it reduces chronic pain after a stroke or from nerve damage in the face. About 20 adults with severe, long-lasting pain will try both the new burst method and standard continuous stimulation to compare…

This study tests a special training program called Mio-Training for children and teens with ADHD. The training combines thinking exercises with physical coordination tasks to improve metacognition (awareness of one's own thinking) and executive functions like planning and focus. …

This study looks at why some stroke survivors develop long-term pain, called central poststroke pain (CPP). Researchers will use brain scans to see how brain connections change in people with this pain. The goal is to better understand the condition, which currently has no effect…

This study tests whether a structured shared decision-making process helps patients with severe aortic stenosis choose between two types of heart valve replacement (TAVR or SAVR). About 140 patients aged 70 and older will be randomly assigned to either the structured approach or …

This study follows 2000 adults who are having weight-loss surgery to see how their pain and daily activities change afterward. Researchers will ask patients about their pain levels, side effects, and how much pain interferes with normal life. The goal is to find out what factors …

This study looks at how two common blood thinners, rivaroxaban and apixaban, are processed by the body in people with mild to moderate liver cirrhosis. 24 adults with compensated cirrhosis will receive a single dose of one of the drugs, and their blood will be tested over 12 hour…

This study aims to make magnetic resonance spectroscopy (MRS) — a technique similar to MRI — more sensitive and reliable for measuring natural chemicals in the body. Researchers will test new scanning methods in about 100 healthy volunteers, including during sleep or after exerci…

This study looks at people with a rare type of small intestinal cancer that has spread and cannot be fully cured. It compares those who had surgery to remove the main tumor with those who did not, to see who lives longer and has fewer complications. The goal is to give doctors cl…

This study aims to find out if a person's genetic makeup influences how much pain they feel after surgery and how much pain medicine they need. Researchers will observe 5,000 adults undergoing planned operations and track their pain levels and recovery for one year. The goal is t…

This study looks at people with a broken spine (thoracolumbar burst fracture) who have no nerve problems. It compares surgery with wearing a brace for 6 weeks to see which leads to better recovery and fewer complications. The goal is to find out if non-surgical treatment works ju…

This study tests whether injecting a small amount of fluid into the space around the lung during a CT-guided lung biopsy can lower the risk of a collapsed lung (pneumothorax). Researchers will also position patients so the biopsy targets gravity-dependent areas. About 198 adults …

This study follows 329 adults who develop an infection after a hip or knee replacement. Researchers will track their treatments and outcomes to see which factors—like patient health, bacteria type, and surgical methods—lead to a cure. The goal is to gather knowledge to improve fu…

This study explores whether a brain mapping technique called navigated transcranial magnetic stimulation (nTMS) can help doctors plan radiation more precisely for people who had surgery for brain tumors near the movement-control area. About 30 adults will have their motor brain a…

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study looks at whether a new digital education and self-management program is practical and helpful for people with fibrotic interstitial lung disease. About 80 participants will use the program on their phone or computer during rehab or clinic visits and share their feedbac…

This study looks at whether having surgery to remove a returning glioblastoma brain tumor helps people live longer and feel better compared to skipping surgery. About 120 adults whose cancer came back after standard treatment will be randomly assigned to either have surgery plus …

This study compares brain aging in 200 people—half with multiple sclerosis (MS) and half healthy—using advanced MRI scans. The goal is to see if MS speeds up brain aging and to find better ways to measure it. Participants will have MRI scans and assessments, but no treatment is g…

This study is testing a questionnaire called QUOCCAS that parents and children fill out to see if it can accurately identify kids with cancer who might have an inherited cancer risk. About 205 children and teens with cancer will take part, and some families will also receive an e…

This study looks at whether doing core muscle exercises right after abdominal surgery can prevent incisional hernias and long-term pain. About 588 adults having abdominal surgery will be randomly assigned to either standard care or a core exercise program. The goal is to see if e…

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and pain. The goal is to identify genetic factors that could help predic…

This study watches 40,000 adults in European hospitals to see what problems happen when doctors help them breathe during anesthesia. It records patient details and any breathing-tube issues to find ways to make anesthesia safer. No new treatments or drugs are tested—just careful …

This study tests whether a structured communication tool, called the StOP?-protocol, helps surgical teams talk more clearly during operations. The goal is to see if using this tool reduces deaths, unplanned return surgeries, and hospital stays. About 400 surgeons and their patien…

This study watches how the eyes of 50 people with wet age-related macular degeneration respond to a higher dose (8mg) of the drug Eylea during the first two months. Researchers use eye scans to measure fluid changes and vision improvements. The goal is to understand early treatme…

This study follows 400 women aged 40-60 to see if hormone replacement therapy (HRT) changes how often or how severely they get respiratory infections like colds or flu. Participants wear a smartwatch to track health signals, and researchers will use this data to build a model tha…

This study looks at whether low levels of immunoglobulins (antibodies) are a treatable cause of fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue levels and infection rates between MS patients with and without low antibody levels. The goal is to und…

This study aims to improve how doctors monitor brain function during surgery. By using accelerometers and microscope video, researchers hope to reduce patient movement during electrical stimulation, making surgery safer. About 203 adults undergoing brain surgery will participate.