Could a less strict diet improve life for adults with rare glycogen storage disease?

NCT ID NCT06852612

Recruiting now Knowledge-focused Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether adults with glycogen storage disease type I (GSDI) can safely include more fructose and galactose in their diet. Currently, patients must avoid these sugars, which limits food choices. Researchers will give 20 adults either fructose alone or fructose plus galactose and measure changes in blood lactate, triglycerides, and uric acid. The goal is to see if relaxed dietary restrictions could improve quality of life without harming metabolic control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fructose and galactose (dietary supplements)
What this could lead to: If successful, this could show that adults with GSDI can safely include more fruits and dairy in their diet, improving food choices and quality of life.
What could go wrong: This is a small, early-phase study with only 20 participants, so results may not apply to everyone. The dietary changes could cause metabolic imbalances in some patients.

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Conditions

The condition(s) this trial relates to.

glycogen storage disease I

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLYCOGEN STORAGE DISEASE TYPE I

Contacts and locations

Locations

Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital
RECRUITING

Bern, 3010, Switzerland
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich
NOT_YET_RECRUITING

Zurich, 8091, Switzerland

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