Abbvie

This study tested an experimental drug called elezanumab in people with a recent cervical spinal cord injury. The goal was to see if it could safely improve arm and hand movement. About 60 adults with severe neck-level injuries received either the drug or a placebo within 24 hour…

This study looked at the long-term safety of the drug linaclotide in children aged 6 to 17 with functional constipation or irritable bowel syndrome with constipation (IBS-C). A total of 381 children who had already completed a previous linaclotide study took the drug for up to 52…

This study looked at how well the drug venetoclax works for adults with newly diagnosed acute myeloid leukemia (AML) who cannot receive strong chemotherapy. About 120 participants in Switzerland and Austria took venetoclax pills daily as part of their normal care. Researchers tra…

This study tested a daily pill called upadacitinib in 1,705 adults with active psoriatic arthritis who had not gotten enough relief from standard non-biologic drugs. The goal was to see if it reduced joint pain and swelling better than a placebo or an injected biologic (adalimuma…

This study tested an experimental drug called ABBV-916 in people with early Alzheimer's disease. The goal was to see if it is safe and can slow down the disease. About 106 participants received either the drug or a placebo through an IV every 4 weeks for 6 months, with an option …

This early-phase study tested an experimental drug called ABBV-CLS-579, alone or with other cancer treatments, in 101 adults with advanced solid tumors that had stopped responding to standard therapy. The main goals were to find safe doses and measure how the drug moves through t…

This study looked at the long-term safety of a daily pill called atogepant for preventing migraines. About 600 adults with chronic or episodic migraine took the drug for up to 156 weeks (about 3 years). The main goal was to see how many people had side effects. This was an extens…

This study tested whether adding venetoclax to azacitidine helps people with untreated acute myeloid leukemia (AML) live longer. About 443 adults who couldn't have standard chemo took part. Two-thirds got the combo, one-third got a placebo plus azacitidine. The goal was to see if…

This phase 3 study tested whether adding venetoclax to low-dose chemotherapy helps older or frail adults with acute myeloid leukemia (AML) live longer. The trial included 211 people who could not tolerate strong chemotherapy. Results showed that the combination improved overall s…

This study followed 240 adults in Taiwan with moderate to severe plaque psoriasis to see how long risankizumab stays effective compared to other biologic drugs. Participants received their prescribed treatment and were monitored for about 2 years. The goal was to measure skin cle…

This early-stage study tested a new drug called ABBV-155, alone or with standard chemotherapy (paclitaxel or docetaxel), in 168 adults with advanced solid tumors that had stopped responding to treatment. The goal was to find safe doses and see if the drug could shrink tumors. The…

This study looked at how well the drug upadacitinib (a daily pill) controls pain in adults with axial spondylarthritis, a type of arthritis that mainly affects the spine. About 650 participants from 19 countries took the drug as prescribed by their doctor and were followed for 12…

This study tests whether adding the experimental drug navitoclax to the standard drug ruxolitinib works better than ruxolitinib alone for people with myelofibrosis, a type of bone marrow cancer. About 252 adults with myelofibrosis took part. The main goal was to see if the combo …

This study tested a daily pill called upadacitinib in over 900 teens and adults with moderate to severe eczema (atopic dermatitis) who needed stronger treatment. The goal was to see if the drug could clear skin and reduce itching better than a placebo. Results showed significant …

This study looked at how well the drug Humira works and how safe it is for people with moderate to severe Crohn's disease in China. About 156 participants took Humira as prescribed by their doctor and were followed for one year. The main goal was to track serious side effects and…

This study looked at how safe and effective the drug upadacitinib is for teenagers aged 12 to 18 with atopic dermatitis (eczema) in Japan. About 167 teens took the drug as prescribed by their doctor and were followed for up to 2 years. The goal was to see how well it works and wh…

This study looked at the long-term safety of a drug called adalimumab in children with ulcerative colitis, a disease that causes inflammation in the colon. 59 children who had already completed a previous study took the drug for up to 2 years. The goal was to see if it was safe a…

This study tested an experimental drug called elezanumab in 121 people who had a recent stroke. The goal was to see if the drug could help improve brain function and recovery compared to a placebo. Participants received the drug or placebo by IV within 24 hours of the stroke and …

This study tested the drug risankizumab (Skyrizi) in 214 adults with moderate to severe genital or scalp psoriasis. Participants received either the drug or a placebo for 16 weeks, then all received the drug for up to a year. The goal was to see if the drug could clear or nearly …

This study tested whether a combination of two drugs, venetoclax and azacitidine, can help adults with acute myeloid leukemia (AML) stay in remission after standard chemotherapy. The goal was to find the safest dose and see if it prevents the cancer from coming back. The study in…

This study looked at the safety and effectiveness of upadacitinib, a drug already approved for rheumatoid arthritis, atopic dermatitis, ankylosing spondylitis, and psoriatic arthritis. About 2,369 Korean adults took the drug as prescribed by their doctor and were followed for 28 …

This study tested a drug called mirvetuximab soravtansine in 79 adults with recurrent ovarian, peritoneal, or fallopian tube cancer that still responds to platinum chemotherapy and has high levels of a protein called folate receptor-alpha. The main goal was to see how many partic…

This study looked at the long-term safety of the drug cariprazine in 310 children and teens with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 52 weeks, researchers monitored side effects, movement changes, and lab results. The goal was to understand the ri…

This study tested the safety and effectiveness of the drug RINVOQ in adults with ankylosing spondylitis, a type of arthritis that mainly affects the spine. About 69 participants in Japan took RINVOQ as prescribed by their regular doctor and were followed for up to 52 weeks. The g…

This study tested an experimental drug called ABBV-668 in 30 adults with moderate to severe ulcerative colitis, a condition causing inflammation and bleeding in the colon. Participants took the drug twice daily for 16 weeks. The goal was to see if it could improve colon healing a…

This study looked at how safe and effective the drug Rinvoq is for adults with moderate to severe ulcerative colitis. About 300 people in Japan took Rinvoq as part of their regular care and were followed for up to 60 weeks. The main goal was to track serious infections and other …

This study compared two already-approved medications, risankizumab (injections every 12 weeks) and deucravacitinib (daily pills), in 393 adults with moderate plaque psoriasis who had not used biologic treatments before. The goal was to see which drug more effectively clears skin …

This study looked at how safe and effective the drug Venetoclax is for people with chronic lymphocytic leukemia (CLL) when used in everyday medical practice. It involved 14 patients who were taking the drug for the first time. The main goal was to track any side effects, and the …

This study looked at over 2,300 adults with moderate to severe plaque psoriasis or psoriatic arthritis who were prescribed Skyrizi (risankizumab) by their doctor. Researchers wanted to see how safe the drug is and how well it controls symptoms over 52 weeks. Participants received…

This study tested a daily medication called upadacitinib in 642 adults with active psoriatic arthritis who had not gotten enough relief from prior biologic drugs. The goal was to see if the drug could reduce joint pain and swelling better than a placebo. Results showed that upada…

This study tested a gel stent implant placed outside the eye to lower eye pressure in people with open-angle glaucoma. About 74 adults aged 45 and older took part. The goal was to see if the stent safely reduces eye pressure by at least 20% while using the same or fewer glaucoma …

This study looked at how safe and effective the drug upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 105 patients took the drug as prescribed by their doctor and were followed for up to 52 weeks. The main goal was to…

This early-stage study tested a gene therapy called RST-001 in 14 people with advanced retinitis pigmentosa, a genetic eye disease that causes severe vision loss. All participants had very poor vision at the start (could only see hand motions or less). The main goal was to check …

This study tested a drug called navitoclax, either alone or added to the standard treatment ruxolitinib, in 191 people with myelofibrosis, a rare bone marrow cancer. The main goal was to see if the treatment could shrink the spleen by at least 35% after 24 weeks. The study also l…

This study tested two drug combinations (venetoclax plus obinutuzumab or ibrutinib) in 20 Japanese adults with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal was to see how well the treatments worked and how safe they were. P…

This study tested a daily pill called upadacitinib in 734 adults with axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. The drug aims to reduce symptoms like pain and inflammation. Participants received either the drug or a placebo, and researchers…

This study tested the long-term safety and effectiveness of tavapadon, an experimental drug, in nearly 1,000 people with Parkinson's disease over 58 weeks. Participants took flexible doses of the drug, and researchers monitored side effects, movement symptoms, and quality of life…

This study tested a drug called upadacitinib in 429 people with giant cell arteritis, a condition that causes swollen arteries. The goal was to see if the drug could help patients achieve remission (no symptoms) while using steroids for a shorter time. Participants received eithe…

This study tracked 150 adults in South Korea with acute myeloid leukemia (AML) who were prescribed venetoclax tablets for the first time. Researchers monitored side effects and how well the drug controlled the cancer over about 7 months. The goal was to see how venetoclax works i…

This study followed 2759 adults with moderate to severe plaque psoriasis to see how well the drug risankizumab works compared to other commonly used biologic treatments. The main goals were to measure how many people achieved 90% clearer skin and how long they stayed on their fir…

This study tested a daily pill called upadacitinib in 912 teens and adults with moderate to severe eczema that wasn't controlled by creams. Participants received either the drug or a placebo for 16 weeks. The main goals were to see if the drug could clear most of the eczema and r…

This study followed over 400 Canadian adults with moderate-to-severe rheumatoid arthritis for about two years. The goal was to see how well the approved drug upadacitinib worked to control their disease in real-world, everyday use. Researchers tracked whether patients achieved lo…

This study tested whether JUVÉDERM VOLITE, a gel filler injected into the skin, can safely reduce horizontal neck lines in Chinese adults. About 159 participants with moderate to severe neck lines were randomly assigned to get the gel or no treatment. The main goals were to see i…

This study followed 226 adults in Israel who were prescribed ubrogepant or atogepant for their migraines. Researchers wanted to see how satisfied people were with these drugs in real life, not just in a lab. Participants took the medicine as their doctor ordered and reported thei…

This study tested a drug called linaclotide in 19 children aged 6 months to under 2 years with functional constipation (hard, infrequent stools). The goal was to see if it safely improves bowel movements and reduces straining. Children took a liquid form of the drug daily for 4 w…

This study tested a new botulinum toxin injection, AGN-151586, for treating moderate to severe frown lines between the eyebrows. About 300 adults who had never used such treatments were randomly assigned to get either the study drug or a placebo. The goal was to see if the treatm…

This early-stage study tested the safety of combining two treatments (AGN-151586 and BOTOX) for moderate to severe frown lines between the eyebrows. 132 healthy adults received a single treatment and were monitored for side effects and immune reactions. The goal was to see if the…

This study tested whether BOTOX injections can safely and effectively reduce the appearance of a wide lower face caused by large masseter (chewing) muscles. About 200 adults with noticeable muscle prominence received either BOTOX or a placebo. The goal was to see if the treatment…

This study tested an experimental drug called ABBV-932 in 161 adults with bipolar I or II disorder who were currently experiencing a depressive episode. Participants took either the drug or a placebo daily for 6 weeks to see if it safely improves mood and reduces depression sympt…

This study looked at how well the drug upadacitinib works for people in Japan with moderate to severe eczema that also causes hard, itchy bumps called prurigo nodularis. About 200 adults and teens took the drug once daily for 48 weeks. The main goal was to see if their worst itch…

This study tested BOTOX Cosmetic in 100 adults with moderate to severe frown lines, crow's feet, and forehead lines. Participants received injections and reported how satisfied they were with the natural look of the results. The goal was to see if BOTOX helps ease the appearance …

This study tested a new drug called CVL-231 (Emraclidine) in 391 adults with schizophrenia who were having a sudden worsening of psychotic symptoms. Participants took either a low dose, a high dose, or a placebo pill daily for 6 weeks. The goal was to see if the drug reduces symp…

This study tested a new dermal filler called HAC 22L in 61 adults who wanted to improve volume loss in their midface (cheek area). Participants either received the filler right away or waited 6 months before treatment. The goal was to see if the filler safely reduces the appearan…

This study tested whether BOTOX injections can safely and effectively reduce the appearance of a wide lower face caused by large masseter (chewing) muscles. About 200 adults with noticeable masseter muscle prominence received either BOTOX or a placebo injection into both sides of…

This study tested whether JUVÉDERM® VOLITE™, an injectable gel, can improve skin quality like hydration and radiance in adults with fine lines and wrinkles. About 135 participants were randomly assigned to receive the gel or no treatment. The study is now complete and measured sk…

This study looked at how satisfied people were with their face and neck appearance after getting a combination of cosmetic treatments like Botox, fillers, and skin products. It included 130 adults with different skin types and backgrounds. The goal was to see if these treatments …

This study tested whether JUVÉDERM® VOLITE™, an injectable gel, can safely improve lines around the mouth in Chinese adults. About 198 participants with moderate to severe lines received either the filler or no treatment. The main goal was to see if the filler reduced line severi…

This study tested whether BOTOX injections can make the jawline look slimmer by relaxing the chewing muscles. About 249 adults with a wide, square lower face received either BOTOX or a placebo. The main goal was to see if the treatment reduced jaw muscle prominence by at least tw…

This study tested a new medication called CVL-231 (Emraclidine) in 385 people with schizophrenia who were having a sudden worsening of psychotic symptoms. Participants took either a low dose, a high dose, or a placebo pill daily for 6 weeks. The main goal was to see if the drug r…

This study tested a drug called onabotulinumtoxinA (a type of Botox) to treat moderate to severe forehead lines in Japanese adults. About 150 participants received either the drug or a placebo injection. The goal was to see if the treatment safely reduces wrinkles when frowning o…

This study tested a drug called linaclotide in children aged 2 to 5 years with functional constipation (hard, infrequent stools). About 123 kids received either the drug or a placebo for 12 weeks, then all could take the drug for 24 more weeks. The goal was to see if the drug saf…

This study followed 120 adults with bipolar I disorder who were starting cariprazine (Vraylar) for a depressive episode. Researchers measured changes in depression symptoms, daily functioning, and quality of life over 24 weeks in routine clinic visits. The goal was to see how wel…

This study tested an experimental drug called ABBV-552 in 263 people with mild Alzheimer's disease. Participants took the drug or a placebo daily for 12 weeks to see if it improved memory and thinking. The goal was to find a safe dose that could ease symptoms of early Alzheimer's…

This study tested whether BOTOX injections can safely reduce shaking in the hands and arms caused by essential tremor. About 174 adults aged 18 to 80 received either BOTOX or a placebo injection over three 12-week cycles. Researchers measured changes in daily tasks like drinking …

This study tested a new drug called tavapadon in 304 people with early Parkinson's disease. The goal was to see if it improves movement and daily living skills compared to a placebo over 27 weeks. Participants took flexible doses of the drug or a dummy pill, and researchers measu…

This study looked at how a new tablet form of the drug venetoclax is absorbed in the body. 72 healthy women took the new tablet and the current tablet to compare them. The study also checked if eating a high-fat meal changes how the new tablet works. This was a phase 1 study with…

This study tested a new drug called ABBV-142 in 73 healthy adults to see if it is safe and how the body handles it. Participants received a single dose, and researchers measured side effects and drug levels in the blood. The goal was to gather early safety information, not to tre…

This study looked at the safety of the drug RINVOQ in over 4,200 Japanese adults with rheumatoid arthritis, a condition that causes joint pain and swelling. Researchers tracked serious infections and other side effects for up to 3 years using routine medical records. The goal was…

This study looked at how much of the drug risankizumab passes into breast milk of women with inflammatory bowel disease (IBD). Ten mothers who were already taking risankizumab every 8 weeks after giving birth provided milk samples. The goal was to understand infant exposure and c…

This study looked at how vitiligo affects people in China, including their treatments and daily life. About 100 patients aged 12 and older took part. The goal was to measure disease severity and quality of life, not to test a new treatment.

This study looked at how a high-fat meal changes the way the drug ABBV-101 moves through the bodies of 17 healthy adults. Participants took ABBV-101 by mouth, and researchers measured drug levels in the blood and checked for side effects. The goal was to understand if food affect…

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This early-stage study tested the safety and how the body handles a new drug called ABBV-8736. Twenty-four healthy adults received either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not to treat any disease.

This early-stage study tested the safety and how the body handles ABBV-932, an experimental oral drug, in 20 healthy Chinese adults. Participants received multiple doses to measure how the drug moves through the body and to check for side effects. The goal was not to treat any di…

This study tested how well risankizumab enters the body when given by a prefilled pen compared to a standard syringe. Fifty-nine healthy adults received the drug one way or the other, and researchers measured drug levels in the blood and watched for side effects. The goal was to …

This study tested a new questionnaire called DermCLCI-p to see if it accurately measures the long-term life impact of psoriasis. 154 adults with moderate-to-severe psoriasis starting the drug risankizumab filled out the survey. The goal was to check if the tool is reliable and us…

This study tested a new on-body injector for risankizumab, a drug used for conditions like psoriasis and arthritis. 260 healthy adults received the drug either through the new injector or a standard syringe. Researchers measured how much drug got into the blood and how the body p…

This early-stage study tested the safety and how the body processes a new drug called ABBV-CLS-616. It involved 110 healthy volunteers who took the drug by mouth. The main goal was to check for side effects and understand how the drug moves through the body. No treatment was give…

This study looked at how the experimental drug ABBV-1354 moves through and leaves the body in 8 healthy adult men. Participants took a single dose containing a tiny radioactive marker so scientists could measure the drug in blood, urine, and stool. The goal was to understand the …

This study tracked 89 Japanese adults with chronic lymphocytic leukemia (CLL) who had already received 24 months of treatment with Venetoclax, with or without Rituximab. The goal was to see how many had undetectable minimal residual disease (uMRD), a sign of deep remission. Resea…

This study looked at how well the drug risankizumab is absorbed when given through a wearable on-body injector compared to a standard injection. It involved 263 healthy adults and measured drug levels in the blood over time. The goal was to see if the new device delivers the drug…

This study looked at how a tablet form of the drug ABBV-722 is absorbed and processed by the body in 11 healthy adults. Researchers also checked whether eating food changes how the drug works. The goal was to gather basic safety and body-processing information, not to treat any d…