Abbvie

This study tested whether a new drug called elezanumab could help people recover better after a stroke. About 120 participants who had just experienced a stroke received either the drug or a placebo through IV infusions every 4 weeks for a full year. Researchers measured whether …

This study tested whether adding a new drug called venetoclax to a standard low-dose chemotherapy (LDAC) works better than the low-dose chemo alone. It involved 211 adults with a new diagnosis of acute myeloid leukemia (AML) who were too old or had other health problems that made…

This study tested two different drug combinations for Japanese adults with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), which are types of blood cancer. About 20 participants were assigned to receive either venetoclax with obinutuzu…

This study tested the long-term safety of cariprazine, a medication, in children and teenagers with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 300 participants took flexible doses of the medication for 52 weeks while researchers monitored for side effect…

This study tested whether adding the medication upadacitinib to steroid treatment could help people with giant cell arteritis achieve and maintain remission. 429 participants with this inflammatory blood vessel condition were randomly assigned to receive either the study drug or …

This study tested an experimental oral medication called ABBV-668 for adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. About 30 participants took capsules twice daily for 16 weeks to see if the drug could reduce intestinal inflammation and …

This study followed 240 adults in Taiwan with moderate-to-severe plaque psoriasis for about 2 years. It compared how well the approved drug risankizumab kept skin clear compared to other similar biologic treatments that patients were already prescribed by their doctors. Researche…

This study followed 413 Canadian adults with moderate to severe rheumatoid arthritis who were prescribed upadacitinib by their doctors. Researchers tracked patients for two years to see how well the medication controlled their joint pain, stiffness, and swelling in real-world set…

This study monitored 308 adults in Japan with moderate to severe ulcerative colitis who were prescribed Rinvoq by their doctors. The goal was to check the drug's safety and how well it controlled the disease in real-world, everyday medical practice. Participants were followed for…

This study tested whether a medication called linaclotide is safe and effective for treating chronic constipation in very young children, aged 2 to 5 years. About 123 children participated. For the first 12 weeks, some received the drug and others received a placebo (a pill with …

This study monitored Korean patients already prescribed upadacitinib for conditions like rheumatoid arthritis, atopic dermatitis, ankylosing spondylitis, or psoriatic arthritis. Researchers tracked side effects and whether patients' symptoms improved over about 28 weeks of standa…

This study tested an experimental pill called ABBV-552 to see if it could help control symptoms in people with mild Alzheimer's disease. About 240 participants, aged 50-90, took either the drug or a placebo (a dummy pill) daily for 12 weeks. Researchers checked for safety, change…

This study tested an experimental drug called mirvetuximab soravtansine for women with recurrent ovarian, peritoneal, or fallopian tube cancers that had previously responded well to platinum-based chemotherapy. The drug is designed like a 'smart bomb' to target and kill cancer ce…

This study tested a new drug called tavapadon to see if it could help people with early Parkinson's disease. Over 300 participants took either the drug or a placebo for 27 weeks to measure improvements in movement and daily activities. The main goal was to see if tavapadon was sa…

This large, completed study tested whether a daily oral medication called upadacitinib could safely reduce the skin rash and severe itching of moderate to severe eczema. It involved over 900 participants, including teenagers and adults, who were candidates for systemic therapy. T…

This study tested the long-term safety and effectiveness of a medication called tavapadon for people with Parkinson's disease. Nearly 1,000 participants who had already completed earlier trials took flexible doses of the drug for 58 weeks. Researchers measured how well it control…

This study monitored the safety and effectiveness of the drug Venetoclax in 14 patients with chronic lymphocytic leukemia (CLL) during routine medical care. It was an observational study, meaning researchers watched and recorded what happened to patients who were already prescrib…

This study observed patients in China with moderate to severe Crohn's disease who were already prescribed the medication Humira (adalimumab). For one year, researchers tracked the drug's safety by recording any serious side effects and measured its effectiveness by seeing how man…

This study tested whether a new medication called CVL-231 (Emraclidine) could help control symptoms in people with schizophrenia who were experiencing a sudden worsening of psychosis. 385 participants received either one of two doses of the drug or a placebo for 6 weeks. Research…

This study tested how well and safely the drug risankizumab (brand name Skyrizi) works for adults with moderate to severe psoriasis in sensitive areas: the genital region or the scalp. About 214 participants received either the real drug or a placebo via injection for up to a yea…

This study tested a different surgical approach for implanting a gel stent to treat open-angle glaucoma. Researchers implanted the device from outside the eye instead of inside to see if this method is safe and effective at reducing eye pressure. The study followed 74 patients fo…

This study followed nearly 600 people for three years to check the long-term safety of a daily pill called atogepant, which is designed to prevent migraine attacks. It focused on people who suffer from either chronic (frequent) or episodic (less frequent) migraines. The main goal…

This study followed over 2,700 adults with moderate-to-severe plaque psoriasis to see how well the drug risankizumab worked compared to other commonly used biologic treatments. Researchers tracked how many patients achieved clear or nearly clear skin, how long treatments worked b…

This study tested whether a liquid form of the adult constipation drug linaclotide is safe and effective for children under 2 years old with chronic functional constipation. Babies and toddlers received the medicine or a placebo daily for 4 weeks to see if it improved how often t…

This study tested whether a daily oral medication called upadacitinib could safely and effectively treat moderate to severe eczema (atopic dermatitis). It involved over 900 teens and adults whose eczema was not well-controlled with creams. The main goal was to see if the pill cou…

This large, completed Phase 3 trial tested a daily pill called upadacitinib for adults with active axial spondyloarthritis, a type of chronic inflammatory arthritis that mainly affects the spine and sacroiliac joints. It compared the drug to a placebo to see if it could better re…

This study tested whether a new oral medication called ABBV-932 could safely help reduce depressive symptoms in adults with bipolar I or II disorder. About 160 participants worldwide were randomly assigned to receive either the drug or a placebo pill daily for six weeks. Research…

This study tested whether adding a new drug called navitoclax to an existing treatment (ruxolitinib) could better control myelofibrosis, a serious bone marrow cancer. It involved 191 adults whose disease was not well-controlled on current treatments. Researchers measured if the t…

This study tested an experimental drug called ABBV-916 in people with early Alzheimer's disease. About 195 participants received monthly IV infusions to see if the drug was safe, how it moved through the body, and if it could reduce harmful amyloid plaques in the brain. The trial…

This study observed how well the medication cariprazine (brand name Vraylar) worked for adults with bipolar I disorder who were experiencing a depressive episode. About 120 patients from the US and Canada were followed for up to 24 weeks in their normal treatment settings. Resear…

This study observed how well and how safely the approved drug RINVOQ worked for adults with ankylosing spondylitis in real-world medical settings in Japan. About 70 participants who were prescribed RINVOQ by their doctors were followed for up to one year. The main goal was to tra…

This study tested whether a daily pill called upadacitinib could help people with active psoriatic arthritis who didn't get enough relief from previous biologic injections. Researchers enrolled 642 participants and compared two doses of the pill against a placebo over 24 weeks, t…

This study tested a new daily pill called Emraclidine (CVL-231) to see if it could help control symptoms in adults with schizophrenia who were having a severe and sudden worsening of their illness. About 391 participants were randomly assigned to receive one of two doses of the m…

This study monitored the safety and effectiveness of the approved leukemia drug venetoclax in real-world patients with acute myeloid leukemia (AML) in South Korea. About 150 adult patients who were prescribed the drug for the first time were observed for about 7 months during the…

This study monitored Korean adults with moderate to severe ulcerative colitis or Crohn's disease who were prescribed the approved drug upadacitinib (RINVOQ) by their doctor. The goal was to collect real-world information on the drug's safety and how well it controls disease sympt…

This study checked the long-term safety and effectiveness of the drug adalimumab in children and teenagers with ulcerative colitis (UC). It involved 59 young patients who had already taken the drug in a previous trial. The main goal was to see if continued use was safe and if it …

This study observed how safe and effective the approved eczema medication upadacitinib was for teenagers in Japan during routine medical care. It followed about 170 adolescents, aged 12 to 18, who were prescribed the drug by their doctors for up to two years. The goal was to gath…

This first-in-human study tested a new drug called ABBV-155, both alone and combined with standard chemotherapy, in adults with advanced solid tumors that had returned or stopped responding to prior treatments. The main goals were to find safe doses and see if the drug showed ear…

This study observed how well the approved drug Venetoclax worked for adults newly diagnosed with a fast-growing blood cancer (AML) who were too old or frail for strong chemotherapy. About 120 patients in Switzerland and Austria were followed for two years as they took the drug as…

This study looked at how well a standard treatment combination works for Japanese adults with relapsed chronic lymphocytic leukemia (CLL) in real-world clinics. It followed 89 patients who took venetoclax pills, with or without rituximab infusions, for two years. The main goal wa…

This study tested whether a new drug called elezanumab could help improve arm and hand movement in people who had recently suffered a neck spinal cord injury. About 60 participants received either the drug or a placebo (inactive substance) starting within 24 hours of their injury…

This first-in-human study tested the safety of an experimental cancer drug called ABBV-CLS-579, both alone and combined with other cancer treatments. The trial enrolled 101 adults with advanced solid tumors who had exhausted standard treatment options. Researchers aimed to find s…

This early-stage study tested the safety of a single injection into the eye for people with advanced retinitis pigmentosa, a genetic disease that causes severe vision loss. It involved 14 adults with very poor vision to see if the treatment was safe and tolerable at different dos…

This study tested if a new daily pill called upadacitinib could better control the joint pain, swelling, and skin symptoms of psoriatic arthritis. It was compared against a placebo (a dummy pill) and an existing injectable treatment, adalimumab (Humira). Over 1,700 adults who had…

This study tested whether Botox injections could safely reduce the appearance of a wide, square jaw caused by prominent chewing muscles. About 250 adults who were bothered by their jaw shape received either Botox or placebo injections into the jaw muscles. Researchers measured ch…

This study tested an investigational product called AGN-151586 for reducing the appearance of frown lines between the eyebrows. About 300 adults with moderate to severe frown lines received either the treatment or a placebo injection. The main goal was to see how well the treatme…

This study tested whether an injectable gel called JUVÉDERM VOLITE is safe and effective for reducing the appearance of fine lines and wrinkles around the mouth. About 198 adults in China were randomly assigned to receive the injections or no initial treatment, and their results …

This study tested a new injectable filler called HAC 22L, designed to add volume to the cheeks. About 75 adults seeking to improve their mid-face volume were enrolled. Participants were randomly assigned to receive the filler immediately or after a 6-month wait, and their results…

This study aimed to check the long-term safety of an oral medication called linaclotide in children and teenagers (ages 6-17) with chronic constipation or irritable bowel syndrome with constipation (IBS-C). It followed 381 young participants who had already taken the drug in earl…

This study aimed to find out how satisfied people were with the natural-looking results of BOTOX treatments for common facial wrinkles. About 100 adults with moderate to severe forehead, frown, and crow's feet lines received BOTOX injections and then answered questionnaires about…

This study tested whether BOTOX injections are a safe and effective way to reduce the appearance of a wide, square jawline caused by prominent jaw muscles. About 200 adults in the U.S. received either BOTOX or a placebo injection and were followed for up to 6 months. The main goa…

This study tested whether a gel injection called JUVÉDERM VOLITE is safe and effective for reducing the appearance of horizontal neck lines. About 159 Chinese adults with moderate to severe neck lines participated. Some received the gel injection, while others were in a control g…

This study observed how well an approved drug, upadacitinib, works for people in Japan with a severe form of atopic dermatitis that causes intensely itchy, painful skin bumps called prurigo nodularis. About 200 participants took the oral medication daily for 48 weeks as part of t…

This study tested whether JUVÉDERM VOLITE injections could improve skin quality by reducing fine lines and increasing hydration and radiance. About 135 adults in China who were dissatisfied with their facial skin's appearance received either the injections or no treatment. Resear…

This early-stage study tested the safety and initial effectiveness of combining a new drug called AGN-151586 with Botox to treat frown lines between the eyebrows. It involved 132 healthy adults with moderate to severe frown lines. The main goal was to see if the combination was s…

This study tested whether BOTOX injections could safely reduce shaking in the hands of people with essential tremor, a condition that makes daily tasks like writing and eating difficult. About 174 adults received either BOTOX or placebo injections in their arm muscles over severa…

This study tested whether BOTOX injections into the jaw muscles could safely and effectively reduce the appearance of a wide, square jawline, which some people find undesirable. About 200 adults with prominent jaw muscles received either BOTOX or a placebo injection. Researchers …

This early-stage study tested how eating a high-fat meal affects how the body absorbs and processes an experimental drug called ABBV-101. It involved 17 healthy adult volunteers who took the drug as a tablet under different food conditions. The main goal was to understand how foo…

This study aimed to test a new questionnaire designed to measure the long-term life impact of moderate-to-severe psoriasis. 154 patients who were starting a standard psoriasis medication (risankizumab) completed the 30-question survey over 28 weeks. The goal was to see if the que…

This early-stage study tested the safety of an experimental drug called GUB014295 in healthy but overweight adults. Researchers gave single and multiple doses to 76 participants to see how their bodies reacted and processed the medication. The main goal was to check for side effe…

This study observed the safety and effectiveness of the approved rheumatoid arthritis drug RINVOQ in real-world medical practice. Researchers reviewed the medical records of over 4,000 Japanese patients taking the drug for up to three years. The main goal was to track the occurre…

This study aimed to understand the real-world impact of non-segmental vitiligo on people in China. Researchers observed 100 patients to learn about their treatment patterns, healthcare use, and how the condition affects their daily life and well-being. The study did not test any …

This study tested whether a new, easier-to-use prefilled pen delivers the same amount of the drug risankizumab into the body as the standard prefilled syringe. It involved 59 healthy adult volunteers to measure drug levels, safety, and how the body processes it. The goal was to s…

This study tested how the body absorbs the drug risankizumab when delivered using a new, wearable on-body injector. It involved 263 healthy adult volunteers. The main goal was to measure drug levels in the blood and check for safety, not to treat any disease.

This study aimed to understand how the body processes and eliminates an experimental drug called ABBV-1354 (Icalcaprant). Eight healthy adult men received a single oral dose containing a tiny, safe amount of radioactive carbon to help track the drug. Researchers measured how much…

This study tested a new wearable injection device for the drug risankizumab, which is used to treat conditions like psoriasis. Researchers compared how the body absorbs the drug when given by this new device versus a standard prefilled syringe. The study involved 260 healthy volu…

This study aimed to measure how much of the IBD medication risankizumab passes into breast milk. It involved 10 breastfeeding women with inflammatory bowel disease who were already receiving the drug as part of their regular treatment. Researchers collected breast milk samples ov…

This early-stage study tested how a new oral compound called ABBV-932 moves through the body and checked for side effects. It involved 20 healthy Chinese adult volunteers to gather basic safety and dosing information. The main goal was to understand how the body processes the dru…

This study tested how a new version of the cancer drug venetoclax is absorbed by the body. It involved 72 healthy female volunteers to compare the new tablet to the current one and see if eating food changes how the drug works. The goal was to gather information to potentially im…

This early-stage study tested a new oral drug called ABBV-CLS-616 in healthy volunteers for the first time. Researchers wanted to understand how safe the drug is, how well people tolerate it, and how the body processes it. The study involved 110 healthy participants and examined …