Abbvie

This study looked at the long-term safety of an experimental drug called CVL-865 for adults whose focal seizures (a type of epilepsy) do not respond to other medications. The trial was open-label, meaning everyone knew they were getting the drug, and lasted 57 weeks. It was termi…

This early-stage study tested an experimental drug called ABBV-303, alone or with another drug (budigalimab), in adults with advanced solid tumors that had stopped responding to treatment. The goal was to check safety and see if the drugs could shrink tumors. The study was termin…

This study tested an experimental drug called telisotuzumab vedotin for people with a specific type of advanced lung cancer (non-squamous non-small cell) that has a MET gene amplification. The goal was to see if the drug could shrink tumors. The trial was stopped early after enro…

This study tested two experimental drugs, budigalimab and ABBV-382, in people with HIV who were on stable antiretroviral therapy (ART). Participants stopped their regular HIV pills under close monitoring to see if the new drugs could keep the virus under control. About 160 adults…

This study tested a liquid medicine called paricalcitol in children aged 0 to 9 years with severe kidney disease who are on dialysis. The goal was to see if the drug could safely lower high parathyroid hormone levels, a common complication. Only 2 children enrolled before the stu…

This study tested whether a combination of two drugs (venetoclax and azacitidine) could help people with acute myeloid leukemia (AML) live longer after a stem cell transplant. The trial included adults and teenagers who had a transplant or were planning one. The goal was to see i…

This study tested the drug cariprazine (Vraylar) for adults with schizophrenia in Japan and Taiwan. About 250 people were planned, but only 34 enrolled before the study was stopped early. Participants took either cariprazine or a placebo for 6 weeks, then could continue on caripr…

This study tested whether BOTOX injections can prevent migraine headaches in adults who have 6 to 14 migraine days per month (episodic migraine). About 775 participants received either BOTOX or placebo injections into their muscles twice, 12 weeks apart. The study was terminated …

This study tested an experimental drug called CVL-871 to see if it is safe and can reduce apathy in people with dementia. Apathy is a common symptom where people lose interest and motivation. The trial enrolled 41 participants with mild to moderate dementia, but it was stopped ea…

This study tested a new medicine, fosigotifator, for adults with major depressive disorder. About 106 people were planned to take either the drug or a placebo for around 144 days to see if it was safe and helped with depression symptoms. The study was stopped early, so results ar…

This study looks at pregnancy outcomes in women who took elagolix (brand names Orilissa or Oriahnn) for endometriosis or uterine fibroids. Since elagolix does not fully prevent ovulation, some women may become pregnant while taking it. The study will compare about 292 women expos…

This study was designed to check the safety and how the body processes an experimental drug called ABBV-1088 in healthy adults from Western, Han-Chinese, and Japanese backgrounds. It also looked at how the drug interacts with another medication (itraconazole). The study was termi…