Abbvie

This study tests whether adding pivekimab sunirine to the standard drugs venetoclax and azacitidine helps adults with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for intensive chemotherapy. About 660 participants will be randomly assigned to receive ei…

This study looks at how well the drug Foslevodopa/Foscarbidopa works for people with advanced Parkinson's disease who are still in the earlier phases of that stage. About 100 adults will receive the drug as a continuous infusion under the skin for up to 6 months. Researchers will…

This study tests a new drug, ABBV-706, against standard treatments for small cell lung cancer that has come back or stopped responding. About 531 adults will receive either ABBV-706 or usual care (topotecan, lurbinectedin, or amrubicin) to see which works better. The goal is to s…

This study tests whether taking the antifungal drug itraconazole changes how the body processes nacresertib, an experimental cancer medication. Healthy adults aged 18 to 65 will receive nacresertib alone and then again with itraconazole to compare drug levels in the blood. The go…

This early-stage study will test a single dose of the drug nacresertib in 12 healthy Japanese adults to see if it is safe and how the body processes it. The main goal is to check for side effects and measure drug levels in the blood. No treatment benefit is expected since partici…

This study will use artificial intelligence (AI) to analyze eye scans from 554 adults with diabetic macular edema (DME). The goal is to see if AI can predict when a person's eye treatment needs to change. Participants will not receive any new treatment; instead, researchers will …

This study looks at how well different labs agree when testing for a protein called FRa in stored tumor samples from women with ovarian cancer. About 1,000 women's archived tissue will be tested, but no new treatments or visits are needed. The goal is to improve consistency of FR…

This study looks at tissue samples from 200 people with relapsed ovarian, fallopian tube, or primary peritoneal cancer to see how often a protein called folate receptor alpha (FRα) is present at high levels. The goal is to understand how common this protein is, which may help doc…