Can a One-Two injection punch smooth frown lines better?

NCT ID NCT07756580

Not yet recruiting Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This early-stage trial is testing whether giving two different botulinum toxin injections in sequence can safely and effectively reduce moderate-to-severe frown lines between the eyebrows. About 120 healthy adults will receive an investigational drug called AGN-151586, followed by BOTOX either 14 or 21 days later. The study tracks side effects and how well the treatment smooths wrinkles over about five months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AGN-151586 and BOTOX (onabotulinumtoxinA) injections
What this could lead to: If successful, this could support a new treatment option for frown lines, potentially offering longer-lasting or more effective smoothing of glabellar lines.
What could go wrong: This is an early-phase study with a small number of participants, so results may not apply broadly. Injections can cause temporary side effects like bruising, pain, or drooping eyelids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLABELLAR LINES

Contacts and locations

Locations

Advanced Dermatology - Lincolnshire /ID# 284012

Lincolnshire, Illinois, 60069, United States

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