New Frown-Line treatment shows promise in large trial

NCT ID NCT05248880

Completed Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new botulinum toxin, AGN-151586, for treating moderate to severe frown lines between the eyebrows. About 300 adults who had never received any botulinum toxin treatment were randomly assigned to get either the study drug or a placebo. The main goal was to see if the treatment safely reduced frown lines at maximum frown after one week, as judged by both doctors and participants.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

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Contacts and locations

Locations

Clear Dermatology & Aesthetics Center /ID# 238990

Scottsdale, Arizona, 85255-4134, United States
Clinical Research Center of the Carolinas /ID# 239064

Charleston, South Carolina, 29407, United States
Clinique D /ID# 239653

Laval, Quebec, H7N 6L2, Canada
DMR Research PLLC /ID# 239061

Westport, Connecticut, 06880, United States
DelRicht Research /ID# 244890

Baton Rouge, Louisiana, 70809, United States
Dr Melinda Gooderham Medicine Profession /ID# 239657

Cobourg, Ontario, K9A 0Z4, Canada
Duplicate_Austin Institute for Clinical Research /ID# 238989

Pflugerville, Texas, 78660, United States
Duplicate_Kavali Plastic Surgery and Skin Renewal Center /ID# 244808

Atlanta, Georgia, 30328, United States
Kalo Clinical Research /ID# 247279

West Valley City, Utah, 84120-2058, United States
Marcus Medical Spa /ID# 241703

Redondo Beach, California, 90277, United States
Maryland Dermatology Laser, Skin, & Vein Institute /ID# 239067

Hunt Valley, Maryland, 21030-3216, United States
Pacific Derm /ID# 239654

Vancouver, British Columbia, V6H 4E1, Canada
SkinDC /ID# 238988

Arlington, Virginia, 22209, United States
Steve Yoelin MD Medical Associate Inc /ID# 243197

Newport Beach, California, 92663, United States
The Centre for Clinical Trials /ID# 245873

Oakville, Ontario, L6J 7W5, Canada
WDC Cosmetic and Research, PLLC /ID# 233935

Wilmington, North Carolina, 28405, United States
YVR Aesthetics Training & Study Centre /ID# 241858

Vancouver, British Columbia, V5Z 1H2, Canada

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