Can a new drug combo outsmart Hard-to-Treat myeloma?

NCT ID NCT07728188

Not yet recruiting Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether an experimental drug called etentamig, combined with pomalidomide, can control multiple myeloma that has come back or stopped responding to treatment. About 520 adults who have already tried 1 to 3 prior therapies will be randomly assigned to receive either the new combination or one of several standard treatments. The study will compare how well each approach shrinks tumors and delays disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental drug called etentamig combined with pomalidomide
What this could lead to: If successful, this combination could offer a new treatment option for people with multiple myeloma that has returned or not responded to prior therapy.
What could go wrong: This is an early-phase trial, so the combination may not prove more effective or safer than existing treatments. Side effects are possible and will be closely monitored.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm plasma cell myeloma Recurrence refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED OR REFRACTORY MULTIPLE MYELOMA

Contacts and locations

Locations

2CA-Braga, Hospital de Braga /ID# 283828

Braga, 4710-243, Portugal
Beth Israel Deaconess Medical Center /ID# 285204

Boston, Massachusetts, 02215, United States
British Columbia Cancer Agency Vancouver Centre /ID# 282147

Victoria, British Columbia, V8R 6V5, Canada
CHRU Tours - Hopital Bretonneau /ID# 281925

Tours, Indre-et-Loire, 37044, France
Cancer And Hematology Centers Of Western Michigan - Grand Rapids /ID# 282591

Grand Rapids, Michigan, 49503, United States
Centre Hospitalier Regional Universitaire de Nancy - Hopitaux de Brabois /ID# 284303

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54511, France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hotel-Dieu /ID# 282025

Nantes, Pays de la Loire Region, 44000, France
Centre Hospitalier d'Avignon /ID# 283509

Avignon, Provence-Alpes-Côte d'Azur Region, 84000, France
Centro Hospitalar De Lisboa Ocidental - Hospital De Sao Francisco Xavier /ID# 283500

Lisbon, Lisbon District, 1449-005, Portugal
Chu de Nice-Hopital Larchet Ii /Id# 283541

Nice, Alpes-Maritimes, 06202, France
Cleveland Clinic Florida /ID# 283692

Weston, Florida, 33331, United States
Clinica Universidad de Navarra - Pamplona /ID# 283290

Pamplona, Navarre, 31008, Spain
Columbia University Medical Center /ID# 283510

New York, New York, 10032, United States
Duke University Medical Center /ID# 283475

Durham, North Carolina, 27710, United States
Epworth Hospital - Richmond /ID# 281877

Richmond, Victoria, 3121, Australia
Erasmus Medisch Centrum /ID# 283408

Rotterdam, South Holland, 3015 CE, Netherlands
Fiona Stanley Hospital /ID# 281879

Murdoch, Western Australia, 6150, Australia
Haukeland University Hospital /ID# 283524

Bergen, Sogn Og Fjordane, 5021, Norway
Hospital General Universitario Gregorio Maranon /ID# 283342

Madrid, 28007, Spain
Hospital Universitario Marques de Valdecilla /ID# 283344

Santander, Cantabria, 39008, Spain
Huntsman Cancer Institute /ID# 283512

Salt Lake City, Utah, 84112, United States
Icon Cancer Care - South Brisbane /ID# 282965

South Brisbane, Queensland, 4101, Australia
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 281398

Meldola, Forlì-Cesena, 47014, Italy
Kaohsiung Chang Gung Memorial Hospital /ID# 282970

Kaohsiung City, 833, Taiwan
Krh Klinikum Siloah-Oststadt-Heidehaus /ID# 283729

Hanover, Lower Saxony, 30459, Germany
Leids Universitair Medisch Centrum /ID# 283142

Leiden, South Holland, 2333 ZA, Netherlands
London Health Sciences Centre - Victoria Hospital & Children's Hospital /ID# 282149

London, Ontario, N6A 5W9, Canada
MD Anderson Houston /ID# 282622

Houston, Texas, 77030-4000, United States
MedStar Georgetown University Hospital /ID# 283734

Washington D.C., District of Columbia, 20007, United States
NHS Lanarkshire /ID# 282021

Airdrie, North Lanarkshire, ML6 0JS, United Kingdom
Northwest Georgia Oncology Centers /ID# 284769

Marietta, Georgia, 30060, United States
Nottingham City Hospital /ID# 282748

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
Novant Health Forsyth Medical Center /ID# 283485

Winston-Salem, North Carolina, 27103, United States
Oregon Health and Science University /ID# 282023

Portland, Oregon, 97239, United States
Peter MacCallum Cancer Centre. /ID# 282692

Melbourne, Victoria, 3000, Australia
Pindara Private Hospital /ID# 283010

Benowa, Queensland, 4217, Australia
Queen Alexandra Hospital /ID# 281839

Portsmouth, Hampshire, PO6 3LY, United Kingdom
Rush University Medical Center /ID# 283095

Chicago, Illinois, 60612, United States
SCRI Oncology Partners /ID# 281380

Nashville, Tennessee, 37203, United States
Sir Charles Gairdner Hospital /ID# 281881

Nedlands, Western Australia, 6009, Australia
St Bartholomews Hospital - Barts Health /ID# 283714

London, Greater London, EC1A 7BE, United Kingdom
Staedtisches Klinikum Karlsruhe /ID# 283569

Karlsruhe, Baden-Wurttemberg, 76133, Germany
The Mount Sinai Hospital /ID# 283535

New York, New York, 10029, United States
Toi Clinical Research - Whittier /ID# 284462

Cerritos, California, 90703, United States
Unidade Local de Saude Sao Joao /ID# 283530

Porto, 4200-319, Portugal
Unidade Local de Saude de Gaia/Espinho /ID# 283492

Vila Nova de Gaia, Porto District, 4434-502, Portugal
Universitaetsklinikum Bonn /ID# 283881

Bonn, North Rhine-Westphalia, 53127, Germany
Universitaetsklinikum Freiburg /ID# 282874

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitaetsklinikum Koeln /ID# 283930

Cologne, North Rhine-Westphalia, 50937, Germany
Universitaetsklinikum Tuebingen /ID# 282873

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsklinikum Ulm /ID# 283884

Ulm, Baden-Wurttemberg, 89081, Germany
Universitaetsklinikum Wuerzburg /ID# 283572

Würzburg, Bavaria, 97080, Germany
Universite de Montreal - Hopital Maisonneuve-Rosemont /ID# 281705

Montreal, Quebec, H1T 2M4, Canada
University Hospitals Cleveland Medical Center /ID# 283527

Cleveland, Ohio, 44106, United States
University Hospitals Plymouth NHS Trust /ID# 283108

Plymouth, Devon, PL6 8DH, United Kingdom
University Of Colorado - Anschutz Medical Campus /ID# 283478

Aurora, Colorado, 80045, United States
University of Arizona Cancer Center /ID# 285339

Tucson, Arizona, 85704, United States
University of California Los Angeles /ID# 282444

Los Angeles, California, 90095-3075, United States
University of North Carolina Lineberger Comprehensive Cancer Center /ID# 281454

Chapel Hill, North Carolina, 27599, United States
University of Rochester Medical Center /ID# 283480

Rochester, New York, 14642, United States
University of Wisconsin Hospitals and Clinics /ID# 282516

Madison, Wisconsin, 53792, United States
VCU Massey Cancer Center: Dalton Oncology Clinic /ID# 283606

Richmond, Virginia, 23298, United States
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 283136

Szombathely, Vas County, 9700, Hungary
Weill Cornell Medicine - Cornell University /ID# 283712

New York, New York, 10065, United States
Western General Hospital - NHS Lothian /ID# 281838

Edinburgh, Edinburgh, City of, EH4 2XU, United Kingdom
Wollongong Hospital. /ID# 282694

Wollongong, New South Wales, 2500, Australia

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