New drug combo targets Hard-to-Treat cancers in early trial

NCT ID NCT06158958

Terminated Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tested an experimental drug called ABBV-303, alone or with another drug (budigalimab), in adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. The study was terminated early, and results are limited.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma neoplasm non-small cell lung carcinoma renal cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS

Contacts and locations

Locations

Carolina BioOncology Institute /ID# 254305

Huntersville, North Carolina, 28078, United States
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 266792

Irvine, California, 92618, United States
City of Hope /ID# 254303

Duarte, California, 91010, United States
Hadassah Medical Center-Hebrew University /ID# 254606

Jerusalem, 91120, Israel
NEXT Oncology /ID# 257395

San Antonio, Texas, 78229, United States
NYU Langone - Laura and Isaac Perlmutter Cancer Center /ID# 256943

New York, New York, 10016, United States
National Cancer Center Hospital /ID# 254359

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East /ID# 261712

Kashiwa-shi, Chiba, 277-8577, Japan
Rambam Health Care Campus /ID# 254608

Haifa, 3109601, Israel
START Midwest /ID# 256945

Grand Rapids, Michigan, 49546-7062, United States
Shizuoka Cancer Center /ID# 261714

Sunto-gun, Shizuoka, 411-8777, Japan
South Texas Accelerated Research Therapeutics /ID# 256944

San Antonio, Texas, 78229, United States
The Chaim Sheba Medical Center /ID# 259408

Ramat Gan, Tel Aviv, 5265601, Israel
The Ohio State University - The James /ID# 260475

Columbus, Ohio, 43210-1240, United States
University of Southern California /ID# 254356

Los Angeles, California, 90033, United States
University of Texas MD Anderson Cancer Center /ID# 254308

Houston, Texas, 77030, United States
Wakayama Medical University Hospital /ID# 254361

Wakayama, Wakayama, 641-8510, Japan
Washington University-School of Medicine /ID# 262943

St Louis, Missouri, 63110, United States

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