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Canadian study checks how well RA drug works in daily life

NCT ID NCT04574492

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This completed study followed 413 Canadian adults with moderate to severe rheumatoid arthritis who were prescribed upadacitinib by their doctors. Researchers tracked how well the drug controlled symptoms like joint pain and stiffness over 24 months. The goal was to see if the drug's benefits seen in earlier trials hold up in real-world settings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
upadacitinib
What this could lead to
If successful, this study could confirm that upadacitinib works well in everyday practice to control rheumatoid arthritis symptoms.
What could go wrong
This is an observational study, not a controlled trial, so results may be less reliable. It also does not test new uses or long-term safety beyond 24 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS (RA)

Contacts and locations

Locations

  • Adachi Medicine Prof. Corp /ID# 223872

    Hamilton, Ontario, L8N 1Y2, Canada

  • Angela Montgomery Medicine Professional Corporation /ID# 231142

    Ottawa, Ontario, K1H 7X3, Canada

  • Applied Medical Informatics Research Inc. (AMIR) /ID# 224321

    Montreal, Quebec, H4A 3T2, Canada

  • Arthur Karasik Medicine Professional Corporation /ID# 225276

    Etobicoke, Ontario, M9C 5N2, Canada

  • Brandusa Florica Medicine Professional Corporation /ID# 222173

    Mississauga, Ontario, L5A 3V8, Canada

  • CISSSBSL -Hopital regional de Rimouski /ID# 224681

    Rimouski, Quebec, G5L 5T1, Canada

  • CIUSSS de l'Estrie - CHUS /ID# 225404

    Sherbrooke, Quebec, J1G 2E8, Canada

  • CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 225021

    Montreal, Quebec, H1T 2M4, Canada

  • Centre de Recherche Musculo-Squelettique /ID# 224513

    Trois-Rivières, Quebec, G8Z 1Y2, Canada

  • Clinique de Rhumatologie de Montreal /ID# 221266

    Montreal, Quebec, H4N 1C6, Canada

  • Credit Valley Rheumatology /ID# 219226

    Mississauga, Ontario, L5M 2V8, Canada

  • Dr Naik-Medical Professional Corporation-Alliance Health /ID# 221195

    Saskatoon, Saskatchewan, S7H 5M7, Canada

  • Dr. Chrisostomos Kouroukis & Dr. Pauline Boulos MPC /ID# 223814

    Dundas, Ontario, L9H 1B7, Canada

  • Dr. Jonathan D. Chan Inc. /ID# 222976

    Vancouver, British Columbia, V5Z 1J9, Canada

  • Dr. Juris Lazovskis Inc. /ID# 224817

    Sydney, Nova Scotia, B1S 3N1, Canada

  • Dr. L. Lisnevskaia Medicine Professional Corporation /ID# 225645

    Oshawa, Ontario, L1H 1B9, Canada

  • Dr. Milton F. Baker Inc. /ID# 224555

    Victoria, British Columbia, V8P 5P6, Canada

  • Dr. S. Gill Medicine Professional Corporation /ID# 225238

    Oakville, Ontario, L6M 1M1, Canada

  • Dr. Sabeen Anwar Medicine Professional Corporation /ID# 224797

    Windsor, Ontario, N8X 1T3, Canada

  • Dr. Sankalp V. Bhavsar Medicine Professional Corporation /ID# 223952

    Burlington, Ontario, L7R 2H3, Canada

  • Dr. Viktoria Pavlova Medicine Professional Corporation /ID# 224536

    Ancaster, Ontario, L9G 3K9, Canada

  • Drs. Rai & Sekhon Medicine Professional Corporation /ID# 224366

    Brampton, Ontario, L6R 0W3, Canada

  • Eastern Regional Health Authority /ID# 223911

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • Fraser Clinical Trials Inc /ID# 225200

    New Westminster, British Columbia, V3L 3W4, Canada

  • Groupe de Recherche en Maladies Osseuses Inc /ID# 222977

    Sainte-Foy, Quebec, G1V 3M7, Canada

  • Imtiaz MS Khan Medicine Prof /ID# 225275

    Mississauga, Ontario, L5M 4N4, Canada

  • Makhzoum Medicine Professional Corporation /Id# 229629

    Oakville, Ontario, L6H 3P1, Canada

  • Manitoba Clinic /ID# 223288

    Winnipeg, Manitoba, R3A 1M3, Canada

  • Nexus Clinical Research /ID# 225896

    St. John's, Newfoundland and Labrador, A1B 5E8, Canada

  • Niagara Peninsula Arthritis Ct /ID# 221472

    St. Catharines, Ontario, L2N 7E4, Canada

  • Paolo Pace Medicine Professional Corporation /ID# 234057

    Cambridge, Ontario, N1R 4S1, Canada

  • Rajwinder S. Dhillon Medicine /ID# 224365

    Niagara Falls, Ontario, L2E 6A6, Canada

  • Rheumatology Associates /ID# 228584

    Saskatoon, Saskatchewan, S7K 0H6, Canada

  • Rheumatology Institute of Montreal /ID# 224045

    Montreal, Quebec, H2L 1S6, Canada

  • Rheumatology Research Associates /ID# 224534

    Edmonton, Alberta, T5M 0H4, Canada

  • Saurash Reddy Professional Corporation /ID# 225288

    Edmonton, Alberta, T6G 0T2, Canada

  • St. Joseph's Healthcare /ID# 224042

    Hamilton, Ontario, L8N 4A6, Canada

  • The Waterside Clinic /ID# 224205

    Orillia, Ontario, L3V 1T5, Canada

  • West Mountain Medical Center /ID# 222975

    Hamilton, Ontario, L9C 5N2, Canada

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