New cancer drug ABBV-155 enters first human tests

NCT ID NCT03595059

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study tested a new drug called ABBV-155, given alone or with standard chemotherapy (paclitaxel or docetaxel), in 168 adults with advanced solid tumors that had come back or stopped responding to treatment. The main goal was to find a safe dose and check for early signs of tumor shrinkage. The study included people with small cell lung cancer, non-small cell lung cancer, and breast cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-155 (a drug given intravenously, alone or with paclitaxel or docetaxel)
What this could lead to: If it works, this could point toward a new treatment option for certain advanced solid tumors like lung or breast cancer.
What could go wrong: This is a very early Phase 1 trial, so the main goals are safety and dosing, not yet proving effectiveness. Many drugs fail at this stage, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast neoplasm hormone receptor-positive breast cancer neoplasm non-small cell lung carcinoma small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

AdventHealth Orlando /ID# 227242

Orlando, Florida, 32803, United States
Antoni van Leeuwenhoek /ID# 222260

Amsterdam, North Holland, 1066 CX, Netherlands
Carolina BioOncology Institute /ID# 201577

Huntersville, North Carolina, 28078, United States
China Medical University Hospital /ID# 214062

Taichung, 40447, Taiwan
Dana-Farber Cancer Institute /ID# 201564

Boston, Massachusetts, 02215, United States
Duplicate_Cedars-Sinai Medical Center-West Hollywood /ID# 204267

West Hollywood, California, 90048, United States
Duplicate_Cross Cancer Institute /ID# 213838

Edmonton, Alberta, T6G 1Z2, Canada
Duplicate_Henry Ford Hospital /ID# 226852

Detroit, Michigan, 48202, United States
Duplicate_Johns Hopkins Bayview Med Cnt /ID# 215095

Baltimore, Maryland, 21224, United States
Erasmus Medisch Centrum /ID# 222341

Rotterdam, South Holland, 3015 CE, Netherlands
Highlands Oncology Group, PA /ID# 201568

Springdale, Arkansas, 72762, United States
Hospital Universitario 12 de Octubre /ID# 239999

Madrid, 28041, Spain
Hospital Universitario Fundacion Jimenez Diaz /ID# 239997

Madrid, 28040, Spain
Johns Hopkins Hospital /ID# 201320

Baltimore, Maryland, 21287, United States
Lifespan Cancer Institute at Rhode Island Hospital /ID# 204256

Providence, Rhode Island, 02903-4923, United States
MD Anderson Cancer Center /ID# 201558

Houston, Texas, 77030, United States
Maastricht Universitair Medisch Centrum /ID# 225220

Maastricht, Limburg, 6229 HX, Netherlands
Mary Crowley Cancer Research /ID# 214168

Dallas, Texas, 75230, United States
NEXT Oncology /ID# 204893

San Antonio, Texas, 78229, United States
National Cancer Center /ID# 241095

Goyang-si, Gyeonggido, 10408, South Korea
National Cancer Center Hospital /ID# 215003

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East /ID# 215130

Kashiwa-shi, Chiba, 277-8577, Japan
National Cheng Kung University Hospital /ID# 206304

Tainan, 704, Taiwan
National Taiwan University Hospital /ID# 205673

Taipei City, Taipei, 100, Taiwan
Northwell Health - Marcus Ave /ID# 204376

New Hyde Park, New York, 11042-2060, United States
Northwestern University Feinberg School of Medicine /ID# 201563

Chicago, Illinois, 60611-2927, United States
Pan American Center for Oncology Trials, LLC /ID# 232128

Rio Piedras, 00935, Puerto Rico
Peter MacCallum Cancer Center /ID# 241676

Melbourne, New South Wales, 3000, Australia
Rambam Health Care Campus /ID# 230813

Haifa, 3109601, Israel
The Chaim Sheba Medical Center /ID# 230812

Ramat Gan, Tel Aviv, 5265601, Israel
UC Irvine Medical Center - Chao Family Comprehensive Cancer Center /ID# 206105

Orange, California, 92868-3201, United States
Univ Hosp Cleveland /ID# 201567

Cleveland, Ohio, 44106, United States
Univ of Colorado Cancer Center /ID# 208365

Aurora, Colorado, 80045, United States
Universitair Medisch Centrum Utrecht /ID# 222357

Utrecht, 3584 CX, Netherlands
University Health Network_Princess Margaret Cancer Centre /ID# 204539

Toronto, Ontario, M5G 2M9, Canada
University of Alabama at Birmingham - Main /ID# 214024

Birmingham, Alabama, 35233, United States
University of Oklahoma, Stephenson Cancer Center /ID# 206820

Oklahoma City, Oklahoma, 73104-5418, United States
Vanderbilt Ingram Cancer Center /ID# 201575

Nashville, Tennessee, 37232-0021, United States
Yale University, Yale Cancer Center /ID# 201542

New Haven, Connecticut, 06510-3206, United States
Yonsei University Health System Severance Hospital /ID# 240648

Seoul, 03722, South Korea

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