New filler injection aims to smooth smile lines
NCT ID NCT05454033
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a dermal filler called JUVÉDERM® VOLITE™ to see if it safely reduces lines around the mouth in Chinese adults. About 198 participants were randomly assigned to get the filler or no treatment. The main goal was a one-point improvement on a severity scale. Results may show whether this filler is a good option for cosmetic improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
JUVÉDERM® VOLITE™ (a dermal filler injection)
What this could lead to
If it works, this could offer a safe and effective option for reducing lines around the mouth, improving skin smoothness and hydration.
What could go wrong
This is a completed phase 3 trial, but results are not yet published. The treatment is cosmetic, so benefits are aesthetic, not medical. Side effects like swelling or bruising are possible.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beijing Hospital /ID# 231393
Beijing, Beijing Municipality, 100730, China
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China-Japan Friendship Hospital /ID# 252139
Beijing, Beijing Municipality, 100029, China
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Hangzhou First People's Hospital /ID# 244111
Hangzhou, Zhejiang, 310003, China
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Huashan Hospital, Fudan University /ID# 231395
Shanghai, Shanghai Municipality, 200040, China
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Nanjing Drum Tower Hospital /ID# 231937
Nanjing, Jiangsu, 210008, China
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Peking University First Hospital /ID# 231392
Xicheng District, Beijing Municipality, 100034, China
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Plastic Surgery Hospital(Institute), Cams, Pumc /ID# 231394
Beijing, Beijing Municipality, 100144, China
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The Third Affiliated Hospital, Sun Yat-Sen University /ID# 231398
Guangzhou, Guangdong, 510630, China
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Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 231396
Wuhan, Hubei, 430022, China
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West China Hospital, Sichuan University /ID# 231740
Chengdu, Sichuan, 610041, China
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Zhongda Hospital Southeast University /ID# 244045
Nanjing, Jiangsu, 210009, China