SOLID TUMOR

This study is testing a drug called neratinib in children and young adults whose solid tumors, brain tumors, lymphoma, or leukemia have returned or did not respond to standard treatments. The main goals are to find a safe dose and see what effects, both good and bad, the drug has…

This early-stage study is testing a new oral medication called HBI-2376 in people with advanced solid tumors that have specific KRAS or EGFR mutations. The main goals are to find the highest safe dose of the drug and to understand how the body absorbs and processes it. The trial …

This early-stage study aims to find the highest safe dose of three cancer drugs—gemcitabine, doxorubicin, and bortezomib—when given together. It is for people with advanced solid tumors or urethral cancer that cannot be removed by surgery and have not responded to standard treatm…

This early-stage study is testing a new oral drug, GSK4418959, for adults with advanced solid tumors that have specific genetic features (called dMMR or MSI-H). The main goals are to find a safe dose, see how the body processes the drug, and check if it can shrink tumors, either …

This early-stage trial is testing a new drug called INBRX-106, both by itself and combined with an existing immunotherapy (pembrolizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how …

This early-stage study is testing a new cell therapy called PD-L1 t-haNK in adults with advanced solid cancers that have spread or can't be surgically removed. The main goals are to find the safest dose and check for side effects in a small group of 16 participants who have alrea…

This early-stage trial is testing the safety and effects of a personalized oral vaccine called NECVAX-NEO1 when added to standard immunotherapy drugs (anti-PD-1/PD-L1) for patients with solid tumors. The vaccine is custom-made for each patient using markers from their own tumor, …

This early-stage study is testing the safety of an experimental drug called LY3200882 in people with advanced solid tumors. Researchers are enrolling 223 participants to determine the highest dose that can be given safely and to look for initial signs that the drug might help con…

This study is testing a new oral drug, ARRY-614, to see if it can make standard immunotherapy drugs (nivolumab and ipilimumab) work better for people with advanced cancers. The first part checks the safety and best dose. The second part will see how well the combinations work to …

This study is testing a new drug called C019199 combined with an existing immunotherapy (sintilimab) for people with advanced solid tumors that have stopped responding to standard treatments. The first part aims to find a safe dose, and the second part will see how well the combi…

This early-stage study is testing the safety and dosing of an experimental pill called inavolisib. It is for people with advanced breast cancer or other solid tumors that have a specific genetic change called a PIK3CA mutation. The study will give the pill alone or in combination…

This study is testing whether adding an experimental drug called RP-3500 to standard radiation therapy is safe and can help control cancer that has spread. It is for people with advanced solid tumors who have a specific change in their ATM gene. The main goals are to find the saf…

This is a first-in-human safety study testing a new cancer treatment called BioTTT001. It is a modified virus designed to be injected directly into tumors to kill cancer cells and stimulate the immune system. The study will enroll 12 adults with advanced solid tumors (like head/n…

This study provides continued access to the cancer drug ibrutinib for patients who benefited from it in previous clinical trials but cannot obtain it through regular commercial channels. It allows about 300 patients with various blood cancers or solid tumors to keep receiving the…

This study is testing a personalized vaccine designed to teach a patient's own immune system to recognize and attack their specific cancer. It is for people with certain solid tumors, including pancreatic cancer and glioblastoma, who have limited treatment options. The main goals…

This is the first human study of an experimental oral medication called HBI-2438 for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find the highest safe dose and understand how the body processes the drug. The study …

This early-stage study is testing the safety and best dose of a new two-drug pill combination (cedazuridine with decitabine) for people with advanced solid tumors. It is for patients whose cancer has continued to grow despite at least two prior treatments and who have no other go…

This is an early-stage safety study testing a new experimental drug called SI-B003 in patients with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to block two different pathways (PD-1 and CTLA-4) that cancer cells use to hide from…

This study is testing an investigational drug called TYRA300 for people with advanced bladder cancer and other solid tumors that have specific changes in a gene called FGFR3. The main goals are to find a safe and effective dose and to see if the drug can shrink or control the tum…

This study is testing an experimental antibody called PRL3-Zumab in people with advanced solid tumors that cannot be surgically removed or have spread. The goal is to see if the treatment is safe and can help control the cancer by measuring how long patients live without their di…

This study is testing an experimental drug called JAB-21822 (glecirasib) for people with advanced cancers that have a specific genetic change called KRAS G12C mutation. The trial aims to find the safest and most effective dose while checking if the drug can shrink tumors. It incl…

This is the first time a new drug called ASP4396 is being given to people. The study aims to find a safe dose and understand how the body handles it. It is for adults with advanced solid tumors that have spread and carry a specific genetic change called KRAS G12D, who have few ot…

This is the first study in humans testing a new drug called DS-1055a. It aims to find a safe dose and check for side effects in 40 adults with advanced solid tumors that have returned or stopped responding to available treatments. The main goal is to understand how the body handl…

This is the first study in people to test a new oral drug called ABSK121-NX. The main goal is to find a safe dose and see how the body processes the drug in 169 patients with advanced solid tumors that have stopped responding to standard treatments. Researchers will also look for…

This is the first human study testing a new cancer drug called AB248, either alone or combined with an existing immunotherapy (pembrolizumab). The trial aims to find safe doses and see if the treatment shows early signs of helping adults with advanced solid tumors that have sprea…

This study is testing a new type of personalized cell therapy called IVS-3001 in adults with advanced solid tumors that have stopped responding to standard treatments. The therapy involves modifying a patient's own immune cells to recognize and attack cancer cells that carry a sp…

This study is testing a new combination of two drugs, D-1553 and IN10018, for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find a safe dose for the combination and to see if it can shrink tumors in patients with can…

This is an early-stage (Phase 1) study to find a safe dose and check the side effects of a new, encapsulated form of a cancer drug called E7389. It is being tested in adults with advanced solid tumors that have not responded to standard treatments. The study will also look at how…

This is a first-in-human study to test the safety and find the right dose of an experimental drug called BL-M02D1. It involves 22 adults with advanced gastrointestinal or other solid tumors that have spread and have no standard treatment options. The main goals are to see how muc…

This early-stage study is testing a new oral drug called OMX-0407 in adults with advanced solid tumors that cannot be surgically removed and have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors in specific ca…

This is an early-stage study to find a safe dose of a new drug called GS-4528 for people with advanced solid tumors. Researchers will test the drug by itself and combined with an existing immunotherapy. The main goal is to understand the side effects and determine the best dose f…

This is a very early-stage study to test the safety and initial effects of a new drug called BGB-R046. It will be given alone and in combination with an existing immunotherapy drug (tislelizumab) to about 75 people with advanced solid tumors that have spread and no longer respond…

This study is testing the safety and effectiveness of a new two-drug combination for people with advanced colorectal and other gastrointestinal cancers that have stopped responding to standard treatments. The trial combines an oral pill (vorbipiprant) with an immunotherapy drug (…

This is an early-stage trial testing a new antibody drug called BYON4228, both alone and combined with an existing immunotherapy (pembrolizumab), for people with advanced solid tumors. The main goals are to find a safe dose and see how the body processes the drug. It is for patie…

This study is testing whether the drug sacituzumab govitecan can help control advanced solid tumors that have grown despite standard chemotherapy. It is enrolling 53 adults with specific types of cancer, including some stomach, esophageal, cervical, lung, and bile duct cancers, t…

This early-stage study is testing a new type of treatment called CATCH T cells in adults with advanced solid tumors that have a specific marker (GPC3). Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, and then infu…

This study is testing whether combining an experimental drug called SKB264 with an existing immunotherapy (pembrolizumab) can help control advanced cancers that have returned or spread. It will involve about 240 people with specific types of cervical, ovarian, prostate, bladder, …

This early-stage trial is testing the safety and effectiveness of a modified virus (VSV-IFNβ-NIS) when given alongside standard immunotherapy drugs (like pembrolizumab or nivolumab/ipilimumab). It is for adults with specific advanced solid tumors—including non-small cell lung can…

This early-stage study is testing whether a lower, potentially safer dose of radiation can effectively treat advanced solid tumors when combined with a drug called 5-aminolevulinic acid (ALA). The drug is meant to make cancer cells more sensitive to the radiation, which could hel…

This early-stage study is testing the safety of a modified virus called BS006, which is injected directly into tumors. It aims to see if the virus can help the body's immune system fight advanced solid tumors in patients who have already tried standard treatments. The study is cu…

This early-stage trial is testing a new cancer drug called S095029, both alone and combined with an existing immunotherapy drug (Sym021). The study aims to find safe doses and see if these treatments show early signs of fighting advanced solid tumors in patients who have run out …

This study aimed to see if regular clinic visits and a pneumonia vaccine could help prevent infections in cancer patients after they received CAR-T cell therapy. The plan was to enroll 50 adults with blood cancers or solid tumors who were getting this specialized treatment. Resea…

This early-stage study aims to understand how a new cancer drug called tuvusertib is absorbed, processed, and eliminated by the body. It will involve 12 participants with advanced solid tumors who have run out of standard treatment options. Researchers will track a tiny radioacti…

This study is testing a new way to watch proton beam therapy as it happens. Researchers are using a special type of PET scan to see exactly where the proton radiation goes inside a patient's body during treatment for solid tumors. The goal is to make this advanced cancer treatmen…