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New 'Living Drug' trial targets Tough-to-Treat cancers

NCT ID NCT04503278

Recruiting now Disease control Sponsor: BioNTech Cell & Gene Therapies GmbH Source: ClinicalTrials.gov ↗

Summary

This is a first-in-human study to test the safety and early effectiveness of a new cell therapy called CLDN6 CAR-T, given with or without an RNA vaccine, for patients with advanced solid tumors that have come back or stopped responding to other treatments. The trial will enroll about 214 adults whose tumors test positive for a specific protein called CLDN6. The main goal is to find the safest and most effective dose, while also looking for early signs that the therapy can shrink tumors.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Charité - Universitätsmedizin Berlin - Campus Benjamin Franklin

    RECRUITING

    Berlin, 12200, Germany

  • Erasmus MC - Universitair Medisch Centrum - Medical oncology

    RECRUITING

    Rotterdam, 3015, Netherlands

  • He Nederlands Kanker Instituut (The Netherlands Cancer Institute) - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)

    RECRUITING

    Amsterdam, 1066, Netherlands

  • Karolinska Comprehensive Cancer Center Cancerstudieenheten Huddinge Karolinska Universitetssjukhuset

    RECRUITING

    Stockholm, 14186, Sweden

  • Medizinische Hochschule Hannover - Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation

    RECRUITING

    Hanover, 30625, Germany

  • Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg

    RECRUITING

    Heidelberg, 69120, Germany

  • Peter MacCallum Cancer Centre

    COMPLETED

    Melbourne, Victoria, 3000, Australia

  • Universitätsklinikum Erlangen - Hämatologie & Intrinsische Onkologie - Medizinische Klinik 5

    RECRUITING

    Erlangen, 91054, Germany

  • Universitätsklinikum Hamburg Eppendorf - II Medizinische Klinik und Poliklinik

    RECRUITING

    Hamburg, 20246, Germany

  • Universitätsklinikum Köln AÖR-Centrum für Integrierte Onkologie (CIO)-Studienzentrum der Klinik I für Innere Medizin (CTU Cologne)

    RECRUITING

    Cologne, 50937, Germany

  • Universitätsklinikum Regensburg - Klinik und Poliklinik für Innere Medizin III

    RECRUITING

    Regensburg, 93053, Germany

  • Universitätsmedizin Mainz - III Medizinische Klinik und Poliklinik

    RECRUITING

    Mainz, 55131, Germany

Conditions

Explore the condition pages connected to this study.

SOLID TUMOR