SOLID TUMOR

This early-phase study tests a personalized cell therapy called TCR-T in 25 adults with advanced solid tumors (like colorectal or lung cancer) that have specific KRAS mutations and haven't responded to standard treatments. The therapy uses the patient's own immune cells, engineer…

This study tests an experimental drug, atamparib, in people with advanced non-small cell lung cancer (a common type of lung cancer) that has spread and stopped responding to standard treatments. The trial has two parts: first, finding the safest dose, then testing how well it wor…

This study tests an experimental drug called BSI-082 in adults with advanced or spreading solid tumors that have not responded to standard treatments. In the first part, patients receive BSI-082 alone at increasing doses. In the second part, they receive BSI-082 plus another drug…

This early-phase study tests whether adding a drug called 5-Azacitidine can help standard immunotherapies work again in people with advanced solid tumors that no longer respond to PD-1 or PD-L1 inhibitors. About 35 adults with certain types of cancer will receive the combination …

This study looks at whether using local ablative therapy (like radiation or heat to destroy tumors) after standard first-line treatment can extend the time before cancer grows again. It will enroll about 1,235 adults with various solid tumors that have spread to a limited number …

This study tests the drug olaparib in 30 women with recurrent or metastatic triple-negative breast cancer that has a specific genetic change (BRCA1 promoter methylation) but no BRCA1/2 mutations. The goal is to see if the drug can shrink tumors or slow cancer growth. Participants…

This study tests a new mRNA vaccine designed to help the immune system attack cancer cells. It is given together with an immunotherapy drug (anti-PD-1) to people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to see if the combination is …

This study tests whether freeze-dried miracle fruit (MiraBurst) can improve taste changes caused by cancer treatment in adults with solid tumors. Participants take one mini-square up to four times daily before meals for 90 days. The goal is to ease a common side effect that can m…

This study collects tumor samples and health information from up to 50,000 adults with hereditary cancers. Researchers will use these samples to create lab models of tumors, helping them understand how these cancers grow and find better treatments. Participants donate tissue and …