SOLID TUMOR

This was an early-stage study to test the safety and find the right dose of an experimental drug called LY3405105 for people with advanced solid tumors. The trial enrolled 54 participants with various advanced cancers to see if the drug was safe and if it showed any signs of shri…

This was an early safety study of a new oral drug called TAS2940 for people with advanced solid tumors that have specific genetic changes (EGFR or HER2). The main goals were to find a safe dose and see how the body processes the drug. The trial was terminated and enrolled 29 part…

This study aimed to test if a new drug called CX-072, when combined with other cancer treatments, could shrink tumors in adults with advanced solid cancers like melanoma. It was a Phase 2 trial designed to measure how well the tumors responded to treatment and to check for side e…

This study tested whether the drug tazemetostat could help control advanced solid tumors that have a specific genetic change called an ARID1A mutation. The drug was given to adult patients whose cancer had progressed after standard treatments. The goal was to see if blocking a re…

This early-stage study tested a new cancer drug called IBI3004 in adults with advanced solid tumors that cannot be removed by surgery. The main goal was to find the highest safe dose that patients could tolerate. Researchers also looked at how the drug affected the cancer and mon…

This was an early-stage study to test the safety of a new drug called KD033 in people with advanced solid tumors that had spread or could not be removed by surgery. The main goal was to find a safe dose by giving the drug to small groups of people at increasing levels. Researcher…

This was an early safety study testing a new drug called LB4330 in patients with advanced solid tumors that had stopped responding to standard treatments. The trial aimed to find the safest dose and see how the drug behaves in the body. It was terminated early and enrolled 40 par…

This early-stage study tested a new oral medication called BBI-825 in people with advanced solid tumors that had stopped responding to all standard treatments. The main goals were to find the safest dose and see how the body processes the drug. The study was terminated after enro…

This was an early safety study testing a new oral drug called MRTX0902, both alone and combined with another cancer drug (adagrasib), in people with advanced solid tumors that have specific genetic mutations in the KRAS pathway. The main goals were to find safe doses and see how …

This early-phase study tested a new drug called BNT142 in people with advanced solid tumors that have a specific marker called CLDN6. The main goals were to find a safe dose and see if the drug showed any signs of helping shrink tumors. The trial included patients with cancers li…

This early-stage trial aimed to find a safe and effective dose for combining two oral cancer drugs (tuvusertib and PLX038) in patients with advanced solid tumors that had stopped responding to standard treatments. The study first tested different dose combinations in a small grou…

This early-stage study tested a new experimental drug called ACTM-838 in patients with advanced solid tumors that had stopped responding to standard treatments. The first part aimed to find the safest and most effective dose, while the second part planned to test that dose in mor…

This study tested whether the drug niraparib could help control advanced solid tumors in patients whose cancer has a specific genetic change called a PALB2 mutation. It involved 22 adults with various cancers (like breast, lung, or pancreatic) that had spread or were locally adva…

This early-stage study tested the safety of an experimental treatment called VAXINIA, which is a modified virus designed to infect and kill cancer cells. It was given to 66 adults with advanced solid tumors that had spread and stopped responding to other treatments. The virus was…

This early-stage study tested a new oral drug called NKT3447 in adults with advanced solid tumors that had progressed despite standard treatments. The main goals were to find a safe dose and see how the body processes the drug. The study was later terminated and focused on specif…

This study tested an oral drug called REC-4881 in adults with advanced solid tumors that had spread and carried specific gene changes (AXIN1 or APC). The goal was to see if the drug was safe and could help control the cancer in people who had already tried standard treatments. Th…

This was an early-stage study to test the safety and find the right dose of a new drug called WBC100. It involved 68 adults with advanced solid tumors that had stopped responding to standard treatments. The main goal was to see how much of the drug patients could tolerate and to …

This was the first study in people to test a new cancer treatment called ASP1012, which is a virus modified in a lab to specifically infect and destroy cancer cells. The main goals were to find a safe dose and check for side effects in adults whose cancer had spread and who had r…

This study tested an oral drug called AB-106 (taletrectinib) for people with advanced solid tumors that had spread and contained a specific genetic change called an NTRK fusion. The goal was to see if the drug could shrink or control these difficult-to-treat cancers. The trial wa…

This was a very early, small pilot study to test the safety of a new CAR-T cell therapy for patients with advanced solid tumors that have a specific protein called ALPP. The study involved only 5 patients who had already tried other treatments without success. The main goal was t…

This study tested an experimental drug called DAY101 (tovorafenib) in people aged 12 and older with advanced solid tumors that had stopped responding to other treatments. The goal was to see if the drug could shrink or control tumors that have specific genetic changes. The trial …

This trial tested whether combining two existing cancer drugs—rucaparib and atezolizumab—could better control advanced solid tumors. It enrolled 130 adults with specific cancers, like lung or bladder cancer, that had certain genetic repair problems or were sensitive to platinum c…

This early-stage study aimed to test the safety and find the right dose of an experimental drug called BGB-3245 in people with advanced solid tumors that had stopped responding to other treatments. It specifically enrolled patients whose tumors had certain genetic changes in the …

This study tested a new type of PET scan to see if it could find returning or spreading thyroid cancer more effectively than standard scans. It involved 149 adults with a history of thyroid cancer who received both the new scan and standard imaging. The main goal was to compare h…