New cancer drug BGB-24714 tested in early trial for solid tumors

NCT ID NCT05381909

Terminated Disease control Sponsor: BeiGene Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study tested a new drug called BGB-24714, which is designed to help cancer cells die. It was given alone or with chemotherapy to 157 adults with advanced solid tumors that had spread or could not be removed. The main goal was to find a safe dose and see how well people tolerated the treatment. The study was terminated early, so full results may not be available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BGB-24714 (a drug that helps cancer cells die), given with or without chemotherapy drugs like paclitaxel, carboplatin, or docetaxel
What this could lead to: If it works, this could point toward a new treatment option for people with advanced solid tumors that have not responded to other therapies.
What could go wrong: This is a very early phase 1 trial, so the main goal is just to find a safe dose. It is too soon to know if the drug will actually shrink tumors or help patients live longer. The trial was also terminated early, so results may be limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal squamous cell carcinoma neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOR, ADULT

Contacts and locations

Locations

Asan Medical Center

SongpaGu, Seoul Teugbyeolsi, 05505, South Korea
Auckland City Hospital

Auckland, 1023, New Zealand
Austin Health

Heidelberg, Victoria, VIC 3084, Australia
Avera Cancer Institute

Sioux Falls, South Dakota, 57105-2108, United States
Banner Md Anderson Cancer Center

Gilbert, Arizona, 85234-2165, United States
Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201-2013, United States
Chongqing Cancer Hospital

Chongqing, Chongqing Municipality, 400030, China
Florida Cancer Specialist (Scri) Sarasota

Sarasota, Florida, 34232, United States
Gachon University Gil Medical Center

NamdongGu, Incheon Gwang'yeogsi, 21565, South Korea
Hackensack University Medical Center

Hackensack, New Jersey, 07601-1915, United States
Henan Cancer Hospital

Zhengzhou, Henan, 450000, China
Hunan Cancer Hospital

Changsha, Hunan, 410013, China
Icon Cancer Centre South Brisbane

South Brisbane, Queensland, QLD 4101, Australia
Intermountain Healthcare

Salt Lake City, Utah, 84143, United States
Mary Crowley Cancer Research

Dallas, Texas, 75230, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
National Cancer Center (Korea)

IlsandongGu GoyangSi, Gyeonggi-do, 10408, South Korea
Next Virginia

Fairfax, Virginia, 22031, United States
Northern Beaches Hospital

Frenchs Forest, New South Wales, NSW 2086, Australia
Peter Maccallum Cancer Centre

Melbourne, Victoria, VIC 3000, Australia
Princess Alexandra Hospital

Woolloongabba, Queensland, QLD 4102, Australia
Samsung Medical Center

GangnamGu, Seoul Teugbyeolsi, 06351, South Korea
Sanford Cancer Center

Sioux Falls, South Dakota, 57104-4663, United States
Scri Florida Cancer Specialist East

West Palm Beach, Florida, 33401-3406, United States
Scri Florida Cancer Specialists North

St. Petersburg, Florida, 33705-1449, United States
Severance Hospital Yonsei University Health System

SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea
Shandong Cancer Hospital

Jinan, Shandong, 250117, China
Shandong Provincial Hospital

Jinan, Shandong, 250021, China
Sunshine Hospital

St Albans, Victoria, VIC 3021, Australia
Tennessee Oncology, Pllc Nashville

Nashville, Tennessee, 37203, United States
The University of Texas Md Anderson Cancer Center (Department Gi Medical Oncology)

Houston, Texas, 77030-4000, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390-7208, United States
University of Washington

Seattle, Washington, 98195, United States
Upmc Hillman Cancer Center(Univ of Pittsburgh)

Pittsburgh, Pennsylvania, 15232-1309, United States

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