New combo therapy shows promise for kids with tough cancers

NCT ID NCT03585465

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a combination of an immunotherapy drug (nivolumab) and low-dose chemotherapy in children and teenagers whose solid tumors had not responded to standard treatments. The goal was to see if the combination was safe and could help control the cancer. The trial was stopped early, but it aimed to find better ways to manage these difficult-to-treat cancers.

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Conditions

The condition(s) this trial relates to.

childhood neoplasm embryonal neoplasm ependymoma Ewing sarcoma low grade glioma malignant glioma neoplasm neuroblastoma rhabdomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Centre Léon Bérard (IHOPe)

    Lyon, France

  • Centre Oscar Lambret

    Lille, France

  • Cliniques Universitaires Saint-Luc (CUSL)

    Brussels, Belgium

  • Hôpital La Timone, AP-HM

    Marseille, France

  • Hôpital Mère-Enfant, CHU Nantes

    Nantes, France

  • Hôpital d'Enfants - CHRU Nancy

    Nancy, France

  • Hôpital de Hautepierre, CHRU Strasbourg

    Strasbourg, France

  • Hôpital des Enfants - CHU Toulouse

    Toulouse, France

  • Institut Curie

    Paris, France

  • University Hospital Ghent

    Ghent, Belgium

  • University Hospital Leuven

    Leuven, Belgium