New pill for rare gene-driven cancers shows early promise but trial halted

NCT ID NCT06005974

First seen Feb 06, 2026 · Last updated May 15, 2026 · Updated 10 times

Summary

This study tested an experimental drug called REC-4881 in 18 adults aged 55+ with advanced solid tumors that have AXIN1 or APC gene mutations. The goal was to see if the drug is safe and shrinks tumors. The trial was stopped early, so results are limited.

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Contacts and locations

Locations

  • American Oncology Partners of Maryland, PA

    Bethesda, Maryland, 20817, United States

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105, United States

  • Cancer Specialists of North Florida

    Fleming Island, Florida, 32003, United States

  • Eastern Connecticut Hematology & Oncology Associates

    Norwich, Connecticut, 06360, United States

  • Hunterdon Hematology Oncology

    Hillsborough, New Jersey, 08844, United States

  • Mary Crowley Cancer Research Centers

    Dallas, Texas, 75231, United States

  • Medical Oncology Hematology Consultants

    Newark, Delaware, 19713, United States

  • Mission Cancer And Blood

    Des Moines, Iowa, 50314, United States

  • Rocky Mountain Cancer Centers

    Denver, Colorado, 80218, United States

  • Saint Luke's Hospital

    Kansas City, Missouri, 64111, United States

  • Sansum Clinic

    Santa Barbara, California, 93105, United States

  • Sharp Memorial Hospital

    San Diego, California, 92123, United States

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

Conditions

Explore the condition pages connected to this study.