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Cancer drug brigimadlin tested for Long-Term use in solid tumour patients

NCT ID NCT06619509

Ongoing Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 6 times

Summary

This study looks at the long-term safety of brigimadlin, a cancer drug taken as tablets, in adults with solid tumours who have already received at least 4 cycles of it in a previous study. About 90 participants will take the drug once every 3 weeks, and doctors will monitor their health and any side effects. The goal is to see if long-term treatment is tolerable and continues to benefit patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
brigimadlin (BI 907828), an MDM2 inhibitor taken as tablets
What this could lead to
If successful, this could show that long-term brigimadlin is safe enough to continue treating solid tumours, potentially helping patients maintain disease control.
What could go wrong
This is a small, early-phase rollover study with no control group, so results may not apply broadly. Side effects could still emerge with longer use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOURS

Contacts and locations

Locations

  • Addenbrooke's Hospital

    Cambridge, CB2 0QQ, United Kingdom

  • Arthur J. E. Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • CTR Eugène Marquis

    Rennes, 35042, France

  • CTR Leon Berard

    Lyon, 69373, France

  • Clinexpert Gyongyos

    Gyöngyös, 3200, Hungary

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Copenhagen University Hospital, Rigshospitalet

    København Ø, 2100, Denmark

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington, 98109, United States

  • Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Helios Klinikum Berlin-Buch

    Berlin, 13125, Germany

  • Henry-Joyce Cancer Clinic

    Nashville, Tennessee, 37232, United States

  • Hospital Clínico de Santiago

    Santiago de Compostela, 15706, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario HM Sanchinarro

    Madrid, 28050, Spain

  • Hospital Universitario Miguel Servet

    Aragon, 50009, Spain

  • Istituto Oncologico Veneto IRCCS

    Padova, 35128, Italy

  • Kanagawa Cancer Center

    Kanagawa, Yokohama, 241-8515, Japan

  • Karolinska Comprehensive Cancer Center

    Stockholm, SE-171 76, Sweden

  • Kyushu University Hospital

    Fukuoka, Fukuoka, 812-8582, Japan

  • Mayo Clinic Cancer Center

    Jacksonville, Florida, 32224, United States

  • National Cancer Center Hospital

    Tokyo, Chuo-ku, 104-0045, Japan

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, Fukuoka, 811-1395, Japan

  • Nebraska Cancer Specialists-Omaha-69066

    Omaha, Nebraska, 68130, United States

  • Northwell Health

    Lake Success, New York, 11042, United States

  • Okayama University Hospital

    Okayama, Okayama, 700-8558, Japan

  • Oncology Center-Maria Sklodowska-Curie Institute

    Warsaw, 02-781, Poland

  • Osaka International Cancer Institute

    Osaka, Osaka, 541-8567, Japan

  • Oslo Universitetssykehus HF, Radiumhospitalet

    Oslo, N-0379, Norway

  • Precision NextGen Oncology

    Beverly Hills, California, 90212, United States

  • Prince of Wales Hospital-Randwick-66496

    Randwick, New South Wales, 2031, Australia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • Sanatorio Finochietto

    CABA, C1120AAB, Argentina

  • Sarcoma Oncology Center

    Santa Monica, California, 90403, United States

  • Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • Sun Yat-Sen University Cancer Center

    Guangzhou, 510060, China

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • The Royal Marsden Hospital, Chelsea

    London, SW3 6JJ, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Tohoku University Hospital

    Miyagi, Sendai, 980-8574, Japan

  • UZ Leuven

    Leuven, 3000, Belgium

  • University College Hospital

    London, NW12PQ, United Kingdom

  • University Hospital Olomouc

    Olomouc, 77900, Czechia

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

  • Universitätsklinikum Tübingen

    Tübingen, 72076, Germany

  • Utah Cancer Specialists Cancer Center

    Salt Lake City, Utah, 84106, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63108, United States

  • West Cancer Center & Research Institute

    Germantown, Tennessee, 38138, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06511, United States

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