ANALGESIA

This study looked at whether adding dexmedetomidine to standard pain relief after cancer surgery helps elderly patients (65-90 years old) live longer. The idea is that this drug may reduce stress, inflammation, and confusion, possibly improving immune function and long-term outco…

This study tested whether a lower dose (15 mg) of the painkiller ketorolac works as well as a higher dose (60 mg) for treating sudden muscle pain in a military emergency department. 110 adults with acute muscle pain received one injection of either dose. The results showed that t…

This study looked at different ways to control pain after breast cancer surgery. 188 women took part to see which method helped them go longer without needing extra pain medicine. The goal was to improve comfort and recovery after surgery.

This study tested if a local pain injection (liposomal bupivacaine) works as well as an epidural for pain relief after open gynecologic surgery. 106 adults participated. The goal was to see if the injection could provide similar pain control and recovery while being more cost-eff…

This study tested a new non-opioid pain medicine called HTX-011 in 116 people having knee replacement surgery. Everyone received the medicine as part of a pain plan that did not include opioids. The goal was to see how well it controlled pain after surgery. The study is complete,…

This study tested two types of nerve blocks to manage pain after cancer surgery on the upper belly. 70 adults received either an erector spinae plane block or an external oblique intercostal plane block. The goal was to see which method reduced the need for morphine and improved …

This study looked at 62 people having back surgery to see which pain relief method works better: a nerve block (erector spinae plane block) or a combination of medicines including ketamine. The goal was to see how well patients recovered and how much extra pain medicine they need…

This study tested three different methods to control pain in children aged 2 to 7 after hernia surgery. The methods were a nerve block near the spine, a block at the tailbone, and local numbing medicine. The goal was to see which one works best and causes the fewest side effects.…

This study tested whether a non-opioid pain management plan, starting with the drug HTX-011 during surgery, could reduce the need for opioid painkillers after hernia repair. 209 adults having open inguinal hernia surgery took part. The goal was to see if fewer people would need a…

This study looked at whether adding a ketamine infusion to standard pain management can reduce the need for opioid painkillers and improve pain control after knee replacement surgery. 100 adult patients were randomly assigned to receive either standard care alone or standard care…

This study tested a non-invasive heart monitor (ANI) to see if it can assess comfort in 20 non-communicating patients at the end of life. The monitor measures heart rate changes to detect stress or pain. Researchers compared ANI readings to nurses' pain scores during a painful pr…

This study tested whether adding ketamine or magnesium sulfate to a standard nerve block could reduce pain and the need for morphine after breast cancer surgery. Sixty adults undergoing mastectomy received one of the two add-ons alongside the numbing medication. The main goal was…

This study tested whether a special nerve block called the erector spinae plane (ESP) block can improve pain control after flexible ureteroscopy, a common surgery for kidney stones. 70 adults were randomly assigned to receive either the ESP block plus standard pain care or standa…

This study tested a procedure called cooled radiofrequency to treat chronic knee pain from osteoarthritis. It compared the standard nerve targets with newer, more complete targets. Ten adults with moderate to severe knee pain were followed for six months to see which approach wor…

This study looked at whether a specific nerve block (recto-intercostal fascial plane block) can reduce pain after epigastric hernia repair. Forty adults having elective surgery received either the block or standard care. The goal was to see if the block delayed the need for extra…

This study tested three different numbing injections (nerve blocks) to see which one provides the best pain relief after a type of chest surgery called thoracoscopic sympathectomy. Sixty adults took part, and researchers measured how long it took before they needed morphine for p…

This study tested whether a nerve block called an erector spinae plane block (ESPB) can reduce pain and the need for painkillers after robotic-assisted partial kidney removal. 46 adults aged 18-70 were randomly assigned to receive either the nerve block or standard care. The goal…

This study tested whether adding a mild sedative called dexmedetomidine to standard pain relief can lower the risk of delirium (sudden confusion) in older adults after cancer surgery. Delirium is common in elderly patients and can lead to worse recovery. The trial involved 1,500 …

This study compared two types of nerve blocks (ESP and RIB) to see which one provides better pain relief after breast surgery. 84 patients received one of the blocks, and researchers measured how much morphine they needed and their pain scores. The goal was to find a more effecti…

This study looked at 75 women who had planned C-sections to see if different pain relief methods affect how soon they start breastfeeding and whether they breastfeed exclusively. The researchers compared TAP blocks (a type of abdominal wall injection) with other pain management o…

This study looked at whether adding nalbuphine to a standard spinal anesthetic (levobupivacaine) could reduce the need for morphine after total hip replacement. Sixty adults were randomly assigned to receive either the standard anesthetic alone or with nalbuphine. Researchers mea…

This study tested two different medicines given continuously during gallbladder surgery to control pain without using strong opioids. 64 adults having laparoscopic gallbladder removal were randomly assigned to receive either dexmedetomidine or lidocaine. The goal was to see which…

This study tested whether adding dexmedetomidine to fentanyl could reduce the amount of fentanyl needed for pain and sedation in full-term newborns on breathing machines. Forty newborns participated. The goal was to see if the combination could safely lower fentanyl doses while s…

This study tested if a special ultrasound-guided nerve block (TAP block) provides better pain relief after planned C-sections compared to standard pain medicine. 100 women between 20-50 years old and weighing 50-100 kg took part. The goal was to see which method lowers pain score…

This study tested two methods of pain control after hip replacement: a continuous erector spinae plane block (ESPB) versus a continuous epidural. Sixty adults having hip surgery took part. Researchers measured how much pain medicine they needed, their pain levels, muscle strength…

This study tested three different nerve blocks to control pain after video-assisted chest surgery. Sixty adults received one of the blocks, and researchers measured how long they could go before needing morphine. The goal is to find the best way to reduce pain and the need for st…

This study tested whether an ultrasound-guided belly muscle nerve block (TAP block) can reduce pain and movement during a minimally invasive heart valve replacement (TAVI). Fifty adults having elective TAVI received either the block plus sedation or sedation alone. The goal was t…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were followed for 90 days to track serious problems like heart attack, stroke, bleeding, or kidney failure. The goal was to help doctors decide if ibuprof…

This study tested whether adding a painkiller called nefopam to standard care could lower the amount of strong opioids needed by ICU patients on breathing machines. 60 adults took part in a double-blind trial where some received nefopam and others standard care. The goal was to s…

This study looked at whether taking aspirin and ketamine together by mouth can help adults whose depression hasn't improved with standard antidepressants. Fifteen people with treatment-resistant depression took the combination for one week. Researchers measured changes in depress…

This study looked at two ways to control pain after open gynecologic cancer surgery: an epidural block and a newer erector spinae plane block. Researchers measured pain scores, opioid use, and how soon patients could move after surgery. The goal was to see if the newer block work…

This study tested two different nerve blocks to see which one provides better pain relief after breast surgery. 62 patients received one of the two blocks. The goal was to reduce pain and the need for strong painkillers like opioids. Results will help doctors choose the best opti…

This study tested whether a special nerve block called PECS can help women who have breast cancer surgery feel less pain and need fewer strong painkillers. 70 women having a type of breast removal surgery took part. The goal was to see if the block reduces opioid use and improves…

This study tested two different nerve block techniques to control pain after shoulder arthroscopic surgery. Fifty adults were randomly assigned to receive either a serratus posterior superior intercostal plane block or a combination of suprascapular and axillary nerve blocks. The…

This study looked at two different nerve blocks to control pain after thigh lift surgery. 42 adults received either a quadratus lumborum block or a lumbar plexus block. Researchers measured pain levels and how long it took for patients to need extra pain medicine.

This study tested two different nerve blocks to control pain after elective neck surgery. 102 adults received either an inter-semispinal fascial plane block or an erector spinae plane block before surgery. The goal was to see which block reduced the need for opioid painkillers du…

This study tested whether giving a sedative called dexmedetomidine during lung surgery (VATS) can reduce coughing and pain, and help patients recover faster. 144 adults having non-intubated VATS took part. The goal was to see if the drug improves comfort and reduces the need for …

This study looked at 120 boys aged 4 months to 12 years having urogenital surgery. It compared two ways to manage pain and reduce confusion (delirium) after surgery: an opioid-free caudal block versus a dorsal penile nerve block plus fentanyl (an opioid). The goal was to see whic…

This study tested whether a numbing injection near the hip (femoral nerve block) works better than IV fentanyl for pain from a broken hip in the emergency room. 104 adults with hip fractures took part. The goal was to see which method provides faster and more effective pain relie…

This study tested two types of nerve blocks to control pain after breast surgery. One hundred adults received either a serratus posterior superior intercostal plane block or a pectoral nerve (PECS II) block. Researchers measured how much morphine patients needed and how well they…

This study tested two methods to reduce pain after a planned C-section: injecting local anesthetic into the belly and wound, versus using morphine in the spine. 46 women participated, and researchers measured how much extra pain medicine they needed in the first 24 hours. The goa…

This study looked at how well BD NRFit spinal needles and syringes work during routine medical procedures involving the spine. 161 patients of any age took part. Researchers measured successful needle placement, syringe function, and any side effects like headaches. The goal was …

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This study looked at 52 adults having brain surgery to see if a monitor called the Surgical Pleth Index (SPI) can predict pain after they wake up. The goal was to help doctors give the right amount of pain medicine before patients wake, reducing pain and side effects. The study f…

This study looked at how two pain medicines, lidocaine (given through a vein) and ropivacaine (given through a small tube in the back), affect each other's levels in the blood during major abdominal surgery. The goal was to see if using them together is safe and could reduce side…

This study looked at how a low dose of the sedative drug dexmedetomidine affects pain signals in the brain. Researchers used brain scans to measure changes in fluid flow. 17 healthy adults took part. The goal was to understand the drug's pain-relieving effects, not to test a new …

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat surgery. Researchers compared those who received opioid painkillers to those who received non-opioid options. The goal was to see if non-opioid treatments could provide…