ANALGESIA

This study compares two types of pain blocks (rectus sheath block and transversus abdominis plane block) given during laparoscopic weight-loss surgery. About 96 adults aged 20-60 will be randomly assigned to one of the two blocks. The goal is to see which method provides better p…

This study looks at whether a single-shot nerve block with ropivacaine can reduce pain and the need for narcotic painkillers in children and teens after ACL reconstruction surgery. About 160 participants aged 13 and older will either receive the nerve block during surgery or not.…

This study looks at whether giving a scalp nerve block before a craniotomy (brain surgery) can lower pain after surgery and reduce the need for strong painkillers. Researchers will compare giving the block before the first cut versus after. The study plans to enroll 64 adults age…

This study tests whether combining esketamine and dexmedetomidine can safely reduce agitation and confusion in intensive care unit (ICU) patients who need breathing support without a tube. About 388 adults will receive either the drug combo or standard care. The goal is to see if…

This study tests whether giving methadone based on a patient's genes can reduce side effects like nausea, sedation, and breathing problems while improving pain control. Researchers will enroll 400 adults over 60 having heart surgery. The goal is to find the safest, most effective…

This study tests if using scalp nerve blocks and a drug called dexmedetomidine can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having brain surgery will be randomly assigned to receive one or both treatments, or…

This study tests whether adding neostigmine to a standard numbing medicine (bupivacaine) in a belly-wall nerve block can improve pain control after cesarean delivery. About 58 women having planned C-sections will receive either the combo or the standard block alone. The goal is t…

This study looks at two methods to control pain after hindfoot surgery: a single nerve block injection versus a small tube (catheter) that delivers numbing medicine continuously for days. The goal is to see which approach reduces pain, cuts down on opioid use, and helps people re…

This study tests a combination of pain medicines and local numbing to improve pain control after brain tumor surgery. The goal is to reduce the need for strong opioids, which can have side effects. 2000 adults having planned brain surgery will take part. The main measure is how m…

This study tests a new ultrasound-guided pain block for high-risk children (ages not specified) having anal or penile surgery. The goal is to see if this block can delay or replace strong pain medicines that can cause breathing or heart problems. Sixty children will be enrolled, …

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…