ANALGESIA

This study tests if an ultrasound-guided nerve block can reduce pain and the need for strong painkillers after ear surgery. About 56 adults having middle ear surgery will either get the block or standard care. The goal is to see if this approach leads to less pain and fewer side …

This study tests whether a special nerve block (SPSIPB) can help control pain and reduce the need for strong painkillers after minimally invasive heart surgery. Sixty adults having heart bypass surgery will be randomly assigned to receive either the nerve block plus standard pain…

This study tests a device called NeuroCuple™ that uses no drugs to manage pain after cesarean delivery. Researchers want to see if it reduces pain and the need for opioid painkillers. The study will include 180 women having a C-section. Half will get the real device, and the othe…

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study tests if a long-lasting painkiller called Exparel can reduce pain and the need for narcotics in children aged 13 and older after knee surgery (MPFL reconstruction). Half of the 100 participants will get Exparel plus a standard painkiller during surgery, and the other h…

This study tests if a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after upper abdominal surgery. About 146 adults having open surgery will receive one of the two drugs injected into the belly lining before the incision is…

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra painkillers after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medication based on either the sta…

This study compares three doses of a medicine called dexmedetomidine, added to the usual numbing shot for arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free longer. About 69 adults having elbow or below-elbow surgery will take part.

This study looks at whether a lower dose (15mg) of the painkiller ketorolac works as well as a higher dose (30mg) for kidney stone pain in the emergency department. About 86 adults with severe pain will receive one of the two doses, and their pain levels will be tracked over seve…

This study tests whether adding a nerve block to a steroid injection works better than a steroid injection alone for people with frozen shoulder (adhesive capsulitis). About 50 adults aged 41-65 with persistent shoulder pain will be enrolled. The goal is to see which approach pro…

This study looks at different ways to manage pain and sedation for adults with broken bones or dislocations in the emergency department. Researchers want to find which method gives the best pain relief and patient satisfaction while keeping side effects low. About 200 adults will…

This study is testing whether a special nerve block (PENG block) given before hip replacement surgery can help reduce pain, lower the need for strong painkillers, and help patients get moving sooner. About 60 adults aged 40-85 who are having hip replacement will take part. The go…

This study looks at whether numbing the upper and lower jaw nerves before surgery can lower pain and the need for extra pain medicine after jaw surgery. About 60 adults having planned jaw surgery will take part. The goal is to see if this nerve block helps control pain better tha…

This study looks at whether a high-dose nicotine patch placed on the skin before and after chest surgery can help male smokers who have quit temporarily feel less pain and need fewer opioids. About 80 men aged 18-75 who smoke regularly will take part. The goal is to find a safer …

This study tests whether adding a second nerve block (called IPACK) to a standard one (adductor canal block) can better control pain and reduce the need for strong painkillers after knee realignment surgery. About 100 adults aged 18-75 having specific knee procedures will take pa…

This study compares two pain-blocking injections (ESPB and PIFB) given before heart surgery to see which one reduces pain and helps patients recover their breathing faster. About 80 adults having their first open-heart surgery will take part. The main goal is to see which method …

This study tests whether giving a single dose of paracetamol or ibuprofen before nose surgery (septorhinoplasty) can reduce the need for stronger opioid painkillers during and after the operation. Researchers will enroll 54 adults and measure total opioid use, pain levels, and re…

This study compares a newer type of nerve block (serratus plane block) to standard local anesthesia for pain control during chest tube placement in intensive care patients. About 70 awake, non-intubated adults will be enrolled. The goal is to see if the nerve block reduces pain s…

This study tests whether an opioid-free anesthesia method can better control pain and agitation in children after cleft lip and palate surgery. About 90 children aged 3 months to 7 years will receive either standard opioid or opioid-free drugs. The goal is to improve recovery and…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered VR from admission through the operation. The goal is to see if this approach is practical and helpful for mothers.

This study compares two types of nerve blocks to see which provides better pain relief after total hip replacement. Fifty adults having hip surgery will receive one of the two blocks. Researchers will measure pain scores and how much extra morphine is needed. The goal is to impro…

This study tests whether adding ketorolac (an anti-inflammatory) to the standard lidocaine numbing shot reduces pain during office hysteroscopy, a procedure to look inside the uterus. About 60 women with abnormal bleeding will be randomly assigned to get either the combined numbi…

This study compares two medicines, dexmedetomidine and dexamethasone, added to a standard numbing drug for a neck nerve block in people having their thyroid removed. The goal is to see which combination provides better pain relief after surgery. Sixty adults will take part in thi…

This study compares two common methods of giving morphine after a planned C-section: injecting it into the spinal fluid versus into the epidural space. The goal is to find which provides better pain control with fewer side effects like nausea or itching. About 120 women having el…

This study tests whether a numbing injection called a TAP block can reduce pain and improve satisfaction for people undergoing heart procedures like angiography or stent placement through the groin. About 100 adults will be randomly assigned to receive either the TAP block or sta…

This study looks at how a person's genes and other factors influence pain after surgery. Researchers will follow 5,000 adults having planned operations to see if certain genetic variants are linked to pain levels and painkiller use. The goal is to better understand and potentiall…

This study tests whether a nerve stimulation device placed on the ear (tAN) reduces pain by causing the body to release its own natural painkillers (opioids). Healthy adults aged 18-65 will receive either real or sham stimulation while also getting a drug that blocks opioids or a…

This study is looking at whether a person's genes affect how they recover from surgery. Researchers will track 20,000 adults having surgery to see if certain genetic differences are linked to complications like nausea, pain, or heart problems. The goal is to better understand the…

This study looks at whether a low-dose form of buprenorphine (a partial opioid) can provide pain relief similar to oxycodone but with less risk of abuse. 120 healthy adults will receive different doses of buprenorphine, oxycodone, or a placebo in separate sessions. Researchers wi…

This study is observing 90 adults who are having open heart surgery to compare three standard pain relief methods: IV pain medicine, an epidural, or a nerve block. The main goal is to see which method is best at preventing chronic pain that lasts 3 months after surgery. Researche…

This study looks at whether giving fentanyl (a strong painkiller) through a mist sprayed on the face or into the nose works well for emergency pain relief. Twenty healthy adults will try both methods to see how much medicine gets into the body and how comfortable it is. The goal …

This study looks at how the brain's natural pain-fighting systems relate to pain relief from a common back injection called a medial branch block. Researchers will measure pain responses to heat and track pain levels in 40 adults with chronic low back pain. The goal is to underst…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life support machine for severe heart or lung failure. Researchers will collect data from 120 adults in UK intensive care units to understand current practices. They will then work with patients, f…

This study follows 2000 adults who are having weight-loss surgery to understand how pain and daily activities change afterward. Researchers will ask patients about their pain levels, medication use, and any lasting effects on their quality of life. The goal is to learn what influ…