Massive study checks ibuprofen safety after joint replacement

NCT ID NCT05575700

First seen Jan 11, 2026 · Last updated Jun 11, 2026 · Updated 21 times

Summary

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were followed for 90 days to track serious problems like heart attack, stroke, bleeding, or kidney failure. The goal was to help doctors decide if ibuprofen is a good choice for pain relief after these common surgeries.

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Contacts and locations

Locations

  • Aalborg University Hospital

    Farsø, 9640, Denmark

  • Bispebjerg Hospital

    Copenhagen NV, 2400, Denmark

  • Gentofte Hospital

    Hellerup, 2900, Denmark

  • Nordsjællands Hospital Hillerød

    Hillerød, 3400, Denmark

  • Næstved Hospital

    Næstved, 4700, Denmark

  • Odense University Hospital

    Odense, 3900, Denmark

  • Private Hospital Gildhøj

    Brøndby, 2605, Denmark

  • Silkeborg Regional Hospital

    Silkeborg, 8600, Denmark

  • Svendborg Hospital

    Svendborg, 5700, Denmark

  • Vejle Sygehus

    Vejle, 7100, Denmark

  • Zealand University Hospital

    Køge, 4600, Denmark

Conditions

Explore the condition pages connected to this study.