Neuralgia

This study tests a new way to inject numbing medicine directly into a specific nerve root to find out which nerve is causing back and leg pain. The goal is to see if this method is safer and more accurate than current techniques. About 80 adults with sciatica who are scheduled fo…

Trigeminal neuralgia causes sudden, severe facial pain often mistaken for a toothache, leading to wrong treatments. This study tests a 15-question screening tool in 250 adults with facial pain to see if it can accurately identify possible trigeminal neuralgia before a specialist …

This study aims to see if common physical exams and diagnostic criteria can accurately identify piriformis syndrome, a cause of buttock pain. Researchers will enroll 75 adults with gluteal pain and compare exam results to an ultrasound-guided lidocaine injection into the piriform…

This phase 3 trial tests whether adding daily calcitonin injections to standard shingles treatment can prevent postherpetic neuralgia, a painful nerve condition that can last for months or years. Researchers will enroll 168 adults aged 50 and older who have had a shingles rash fo…

This pilot study tests whether placing a soft tissue matrix over a nerve during forearm flap surgery can prevent chronic pain and numbness. Eighty head and neck cancer patients will be randomly assigned to receive either the matrix or standard closure. The main goal is to see if …

This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessio…

This study tests whether taking a daily capsule of decaffeinated green tea extract can reduce nerve pain in people who have had cancer treatment. The trial enrolls 20 adults with stable pain who are not currently undergoing cancer therapy. Participants receive either the green te…

This study compares two manual therapy techniques—myofascial release and post-isometric relaxation—for treating piriformis syndrome, a condition where a muscle in the buttock presses on the sciatic nerve, causing pain, numbness, and tingling. Twenty-six adults aged 20 to 50 with …

This study investigates whether giving lidocaine or dexmedetomidine through a vein during urethral reconstruction surgery can lower pain right after surgery and reduce the chance of chronic pain lasting months later. About 80 adults scheduled for this surgery will receive one of …

This trial compares three treatments for idiopathic trigeminal neuralgia, a condition causing severe facial pain. One group gets standard carbamazepine alone, another adds the antiviral acyclovir, and the third adds the anti-inflammatory celecoxib. The goal is to see which combin…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This study investigates whether a high-concentration capsaicin patch can reduce chronic neuropathic pain in the pelvic and perineal region. Researchers will measure changes in pain sensitivity before and after treatment in 30 adults with long-lasting pelvic nerve pain. The goal i…

This study compares two muscle energy techniques—post-isometric relaxation and reciprocal inhibition—for treating piriformis syndrome, a condition causing buttock pain and limited movement. Researchers will enroll 42 adults aged 25-40 with confirmed piriformis syndrome and modera…

This study tests whether a newer form of spinal cord stimulation (paresthesia-free SCS) actually reduces chronic pain or if its benefits are just a placebo effect. Ninety adults with severe neuropathic pain will receive both active and placebo stimulation for six weeks each, with…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study tests a device called Scrambler Therapy to relieve nerve pain in children with cancer that has spread to the bone. The treatment is non-invasive and aims to lower pain levels and reduce the need for pain medications. About 70 children who can describe their pain will t…

This study tests if botulinum toxin (like Botox) provides longer-lasting pain relief than a standard numbing injection for people with chronic nerve pain after losing a limb in combat. About 100 adults with confirmed nerve pain will get one of the two injections and be tracked fo…

This study tests whether injecting botulinum toxin (like Botox) into the piriformis muscle can reduce pain and improve quality of life in people with piriformis muscle syndrome. About 108 adults who have had buttock or leg pain for at least 3 months and haven't gotten relief from…

This study tests a lidocaine spray (APC101) for people with postherpetic neuralgia, a painful nerve condition after shingles. The spray delivers pain relief without touching the sensitive skin. About 333 adults will use the spray or a placebo to see if it reduces pain over 24 hou…

This study tests whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve daily function in people with peripheral neuropathy who also have plantar fasciitis (heel pain). About 114 adults will receive either real or sham shockwave treatment. The goal is to see …

This study compares two non-invasive laser treatments—high-intensity and low-level—for people with trigeminal neuralgia, a condition causing severe facial pain. About 38 adults who haven't found relief from medication or can't have surgery will receive one of the two laser therap…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study tests whether a spinal cord stimulator can reduce chronic nerve pain caused by chemotherapy. 68 adults with pain lasting over a year will have the device implanted and then randomly receive either active or sham stimulation. The goal is to see if active stimulation pro…

This study tests an experimental drug called SP-102 for people with moderate to severe sciatica (leg and back pain). About 755 adults will receive a single injection of SP-102, a placebo, or an active comparator. The goal is to see how well SP-102 reduces pain and improves daily …

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This study tests whether electroacupuncture can improve sleep in people with long-term sciatica caused by a slipped disc. About 114 adults with chronic insomnia and leg pain will receive either real electroacupuncture or a sham version three times a week for four weeks. Researche…

Stanford University is testing a wearable ultrasound device that targets peripheral nerves to reduce chronic pain. The device is placed on the skin over the painful area and delivers focused ultrasound waves. In this early study, 90 adults with nerve-related pain will attend a si…

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study compares a specialized posture-correction exercise program (Mirror Image Spine Correction) with standard physiotherapy for adults with sciatica. Over 12 weeks, 64 participants will receive supervised sessions three times per week. The main goal is to see if the new exe…

This study compares two common back surgeries for people with lumbar spinal stenosis (a narrowing of the spine that presses on nerves). One surgery only removes the pressing bone and tissue, while the other also adds metal screws and rods to stabilize the spine. Researchers will …

This study looks at whether different doses of steroid injections work equally well for treating sciatica (nerve pain in the lower back and leg). About 150 adults with MRI-confirmed lumbar radiculopathy who have not had back surgery will receive one of several doses of either tri…

This study compares two treatments for buttock pain caused by piriformis syndrome and related muscle pain. Researchers will use ultrasound to guide either a sugar-water injection or a dry needle into the affected area. The goal is to see which method provides better pain relief o…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can reduce pain in people with trigeminal neuralgia, a condition causing severe facial pain. 126 participants will either get real electroacupuncture or a sham version, while continuing …

This study tests whether a non-invasive brain stimulation device can reduce the persistent nerve pain that sometimes follows a shingles infection. Researchers will compare real stimulation to a sham (fake) procedure in 94 adults who have had pain for at least 3 months. Participan…

This study tests whether dexamethasone palmitate, a steroid, can better relieve shingles pain and prevent long-term nerve pain compared to standard care. About 954 adults with shingles rash and severe pain will receive the drug by injection or infusion. Researchers will track pai…

This early study tests a brain stimulation device for people with long-term nerve pain that hasn't responded to other treatments. The device is surgically placed to send mild electrical pulses to specific brain areas. The main goal is to see if the procedure is feasible and accep…

This study tests two types of pulsed radiofrequency treatments for people with severe trigeminal neuralgia, a condition causing intense facial pain. 62 adults who haven't found relief from medication will receive either a standard or a new irregular-pulse technique. The goal is t…

This study tests an injectable supplement that combines B vitamins with an energy molecule (ATP) to treat painful diabetic nerve damage. Two hundred adults with diabetes and nerve pain will receive either the ATP-enhanced shot or a standard B vitamin shot for 12 weeks. Researcher…

This study tests whether aromatherapy foot massage can reduce neuropathic pain in people with type 2 diabetes. 78 participants will massage their feet for 10 minutes, three times a week for 4 weeks. Researchers will compare the effects of an aromatherapy oil versus a plain oil to…

This study tests whether doctors can safely perform ultrasound-guided pain procedures, like nerve blocks, at home for patients with chronic or cancer pain. It includes 100 adults already receiving home hospital care. The goal is to see if this approach reduces pain, cuts down on …

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This study tests a new approach to reduce nerve pain in people with spinal cord injury. Ten participants will receive ten sessions combining mild brain stimulation (tDCS) with virtual reality walking and muscle vibration. The goal is to see if this drug-free combo can lower pain …

This study tests if a long-lasting numbing drug (liposomal bupivacaine) injected into the scalp before surgery can reduce pain after a specific type of brain surgery called microvascular decompression. About 100 adults having this surgery will be randomly assigned to receive eith…

This study tests whether a gentle, hands-on movement technique applied to the non-painful side can reduce pain and disability in people with cervical radiculopathy (nerve pain in the neck and arm). It includes 40 adults who will receive a single session of this technique. The goa…

This early study tests whether an extended-release form of glibenclamide (glyburide), a diabetes drug, can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will receive either the drug or a placebo. The main goal is …

This study compares two types of pulsed radiofrequency treatments for postherpetic neuralgia, the long-lasting nerve pain that can follow a shingles infection. One hundred adults whose pain has not responded to standard care will receive either the regular or a new 'STP' irregula…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study follows 150 adults who had a traumatic arm or leg amputation to see if a stump infection increases the risk of long-term pain. Researchers will check pain levels at 3 and 6 months after surgery. The goal is to understand if preventing infections could reduce chronic pa…

This study looks at 180 adults getting a heart device (like a pacemaker) for the first time. Researchers will track their pain and quality of life for a year, using surveys and a pressure gauge. The goal is to build an AI system that can predict who is at risk for long-term pain,…

This observational study looks at how people with chronic pain experience pleasant touch and how often they encounter it in daily life. Researchers want to see if these experiences are linked to pain sensitivity and body awareness. About 100 adults referred to a pain clinic in Sw…

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study follows 150 adults with severe arm or leg injuries to see if developing a blood clot raises the risk of long-term pain. Participants are enrolled within 72 hours of hospital admission and monitored for six months. The goal is to understand how blood clots and pain are …

This study looks at whether early ultrasound scans of burn scars can predict which patients will have persistent pain 3 to 6 months later. Researchers will measure scar thickness, blood flow, and nerve involvement in 150 adults with blast or drone-related burns. The goal is to id…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury to see who develops long-term pain. Researchers will track pain levels, mental health, and physical factors for 6 months. The goal is to create a tool that can predict chronic pain risk…

This study watches 15 adults with severe cancer pain who are getting a procedure called cordotomy to block pain signals. Researchers will use MRI scans to check for swelling in the spinal cord right after and one month later. The goal is to see if swelling relates to how well the…

This study will follow 120 adults with sciatica from a herniated disc who receive a standard steroid injection. Researchers want to see if the speed and pattern of pain relief in the first few days and weeks can predict whether the treatment is still working at 3 and 6 months. Pa…

This study creates a large international database to monitor how well spinal cord stimulation and similar nerve therapies work for people with chronic nerve pain. Researchers will collect real-world data from 1,000 patients across multiple countries to track safety, quality of li…

This study looks at how Gamma Knife radiosurgery affects brain connections in people with severe facial pain called trigeminal neuralgia. About 28 adults will get brain scans before treatment and at 1, 3, and 12 months after. The goal is to see if changes in brain wiring match pa…

This study looks at whether using artificial intelligence (AI) can help physical therapists make better treatment choices for people with myofascial pain syndrome (a type of muscle pain). About 70 adults with chronic muscle pain will be split into two groups: one gets therapy dec…

This study looks at why some people with type 2 diabetes develop painful nerve damage while others do not. Researchers will measure how the central nervous system processes pain in 128 adults aged 18-80 who have had diabetes for at least one year. The goal is to better understand…

This study looks at 700 adults with trigeminal neuralgia who had a balloon compression procedure to relieve facial pain. Researchers will use machine learning to analyze past patient data and create a model that predicts if pain will come back. The goal is to identify key factors…

This study looks at people who had surgery for a severe facial pain condition called trigeminal neuralgia. Researchers want to know if dental treatments or other mouth stimulation after surgery can make the pain come back. About 100 participants will answer surveys about their pa…