Neuralgia

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests a small implanted device that sends mild electrical pulses to nerves to relieve chronic pain from injury or surgery. About 89 adults with long-lasting pain in the back, shoulder, knee, or foot will either get the implant plus usual care or usual care alone. The g…

This study tests whether two devices, used one after the other, can reduce pain and disability from temporomandibular joint (TMJ) disorders. Adults aged 22 and older with TMJ pain will receive four treatment sessions and be followed for three months. Researchers will measure chan…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This study investigates whether foot massage using a roller can reduce nerve pain caused by chemotherapy in cancer patients. About 80 adults receiving certain chemotherapy drugs will either receive foot massage twice daily for three weeks or continue with routine care. The goal i…

This study tests whether a pain-relief gel (pregabalin) delivered through the skin using ultrasound can reduce pain and improve hand function in people with carpal tunnel syndrome. The treatment is given four times a week for a month, and compared to standard ultrasound therapy w…

This study tests whether giving Botox injections early can reduce nerve pain that occurs after chest surgery (thoracoscopy or thoracotomy). Participants have had daily nerve pain for three months. The trial compares Botox to a placebo to see if it lowers pain intensity and preven…

This study tests a special nerve cap (Axoguard Large-Diameter Nerve Cap) in 15 adults who have had a limb injury or amputation. The cap is placed over the cut nerve end to protect it and may help reduce chronic nerve pain. The goal is to see if the cap is safe and works well befo…

This study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…

This study looks at whether taking vitamin D can reduce nerve pain caused by chemotherapy in people with low vitamin D levels. About 120 cancer patients will be split into two groups: one gets vitamin D supplements, the other gets standard care. The goal is to see if vitamin D he…

This study tests a spinal cord stimulator (BurstDR) to relieve chronic pain from diabetic neuropathy. Twenty adults with long-lasting leg pain will try a temporary device for one week. If their pain drops by at least half, they can get a permanent implant. The study tracks pain l…

This study tests whether walking with a robotic exoskeleton three times a week for 12 weeks can reduce nerve pain in people with spinal cord injury. Forty adults with traumatic spinal injury and persistent nerve pain will be randomly assigned to either robotic walking or a relaxa…

This study tests a new drug called LY3848575 for people with long-term nerve pain starting in the feet and moving up the legs. About 558 participants will receive either the drug or a placebo to see if it safely reduces pain. The trial lasts up to 30 weeks and measures pain inten…

This study looks at whether adding a daily 30-minute muscle stimulation session can improve pain control and quality of life for people who already have a spinal cord stimulator (BurstDR) for chronic back pain. Sixty adults with failed back surgery syndrome or persistent spinal p…

This study compares two exercise programs—asynchronous telerehabilitation (remote guidance) and a standard home exercise plan—for people with piriformis syndrome, a condition causing buttock and leg pain. About 46 adults aged 18-45 with confirmed diagnosis will participate. The g…

This study tests a self-guided web program called Face-Forward-Web for adults with chronic orofacial pain (lasting over 3 months). The program includes five 30-minute video sessions teaching relaxation, mindfulness, and coping skills. Researchers will enroll up to 30 participants…

This early-stage study tests whether BHV-7000 can reduce chronic pain in people with inherited erythromelalgia, a rare condition causing severe burning pain due to a genetic mutation. Only 5 adults with a specific NaV1.7 mutation will participate, comparing the drug to a placebo …

This study compares a 6-month physiotherapy program focused on pelvic floor relaxation to no structured exercise in women with pudendal neuralgia, a chronic pelvic pain condition. Researchers will measure muscle stiffness using ultrasound and track symptoms like pain and sexual d…

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a small, implantable device that stimulates nerves to relieve chronic pain after injury or surgery. About 185 adults with peripheral neuralgia will either receive the stimulator plus standard medical care or standard care alone. The goal is to see if the device p…

This study tests an experimental drug called ONO-1110 to see if it can safely reduce pain in people with postherpetic neuralgia, a type of nerve pain that persists after a shingles infection. About 140 Japanese adults with pain lasting at least 3 months will receive either the dr…

This study tests whether a progressive exercise program can reduce chronic pain in veteran lung cancer survivors aged 60-80. Nine participants will do treadmill walking, resistance bands, and balance exercises. The goal is to see if exercise can be a safe alternative to opioids f…

This study tests whether yoga can reduce nerve pain caused by chemotherapy in cancer survivors. About 227 participants will either take yoga classes twice a week for 8 weeks, attend educational sessions, or receive standard care. Researchers will measure pain, balance, fall risk,…

This study tests if acupuncture can reduce nerve pain caused by chemotherapy in cancer survivors. About 255 people who finished chemo at least three months ago will receive either real or sham acupuncture. The goal is to see if this drug-free approach can ease pain and improve da…

This early-phase study tests whether MRI-guided focused ultrasound can safely reduce severe facial pain in people with trigeminal neuralgia that hasn't responded to medication. Ten adults aged 21-75 with chronic pain for over 6 months will receive a precise ultrasound treatment t…

This study tests a daily drug called basimglurant for adults with trigeminal neuralgia, a condition causing severe facial pain often called the 'suicide disease.' The trial includes 166 people who still have pain despite current treatments. After an 8-week run-in on the drug, par…

This study compares two types of hands-on therapy—Stecco Fascial Manipulation and Rolfing Structural Integration—for people with piriformis syndrome, a condition that causes buttock and leg pain. Forty-two adults aged 25 to 45 with at least four weeks of pain will receive four we…

This study tests whether a noninvasive electrical stimulation device placed on the skin over the spine can reduce pain and improve quality of life in people with neuropathic (nerve) pain. About 62 adults with chronic low back pain from nerve damage will receive either real or sha…

This small study tests whether eptinezumab, a drug used for migraines, can reduce pain in people with atypical facial pain that hasn't responded to other treatments. Ten participants will receive two intravenous infusions three months apart. The main goal is to see if the drug im…

This study looks at whether a combination of herbal medicine and Chuna manual therapy (a Korean spinal manipulation technique) can safely reduce pain and improve walking ability in people with low back pain or sciatica caused by lumbar spinal stenosis or spondylolisthesis. Resear…

This study looks at adults with chronic pain who receive ketamine infusions at Stanford's Pain Management Center. Researchers want to understand which patients improve and what factors predict a good response. The goal is to better tailor this treatment to individuals.

This study looks at whether adding dynamic stretching to foam rolling helps people with piriformis syndrome more than foam rolling alone. Forty adults aged 35–50 with buttock pain will do either foam rolling or foam rolling plus dynamic stretches for several weeks. Researchers wi…

This study compares carbamazepine and oxcarbazepine, two drugs used to treat trigeminal neuralgia, a condition causing severe facial pain. Researchers will enroll 122 adults aged 18-60 who have had the condition for at least two weeks. They will measure pain relief using a standa…

This study tests a precise radiation treatment for trigeminal neuralgia, a condition that causes severe facial pain. Instead of a metal frame screwed into the skull, a special face mask holds the head still while x-rays target the painful nerve. The trial includes 40 adults whose…

This study treated one 58-year-old man with polyneuropathy caused by POEMS syndrome using his own fat-derived stem cells. He received eight infusions over 28 weeks to try to relieve nerve symptoms. The study is no longer available and was not a formal clinical trial.

This study planned to test photobiomodulation (a type of light therapy) on nerve pain and sensation in one woman after mastectomy. The treatment used red and near-infrared light on the affected area for six weeks. However, the study was withdrawn before any participants enrolled,…

This study tests two types of nerve stretches—active (patient-controlled) and passive (therapist-applied)—to see which better reduces burning pain, improves muscle strength, and increases joint movement in people with diabetic neuropathy. Sixty adults aged 40 to 65 with diabetes …

This study looks at whether people with flat feet (pes planus) are more likely to have piriformis syndrome, a condition that causes pain in the hip and lower back. Researchers will compare foot posture and pain in adults aged 18-65 who have piriformis syndrome with those who do n…

This study looks at how the nervous system becomes overly sensitive in people with different types of chronic pain. Researchers will assess 185 adults using questionnaires, thinking tests, and laser brain-wave measurements at the start and after one year. The goal is to better un…

This study was designed to observe brain wave (EEG) changes in adults with chronic neuropathic pain during ketamine treatment. Researchers hoped to find patterns that could predict which patients benefit most. However, the study was withdrawn before enrolling any participants, so…

This study looks at people with trigeminal neuralgia, a condition that causes severe facial pain. Researchers want to see if adding virtual reality (VR) training before Gamma Knife surgery can improve pain relief. They will also use artificial intelligence (AI) and brain scans to…

This study looks at how common nerve problems are in people who feel eye discomfort. Researchers will test 1,000 participants to see if their pain is linked to nerve damage rather than just dry eye. The goal is to better understand these conditions and improve diagnosis.

This study aimed to find out how many people with trigeminal neuralgia (a severe facial nerve pain condition) also have temporomandibular disorder (TMD), which causes jaw pain. Researchers planned to follow patients from three clinics and test a questionnaire to better diagnose b…

This study looks at 150 people with knee osteoarthritis to see how often night pain and nerve pain (neuropathic pain) occur together. Researchers will use questionnaires and physical exams to measure pain and sleep quality. The goal is to better understand these pain types and th…