Mental disorder

This study tests whether giving pasteurized donor human milk to full-term babies of mothers with diabetes during the first five days of life can reduce the number of infants admitted to the neonatal unit for low blood sugar. About 1,444 mothers and their newborns will be randomly…

This phase 2 trial tests whether semaglutide, a GLP-1 drug used for diabetes and weight loss, can help adults with opioid use disorder avoid using illicit opioids. Participants already receiving buprenorphine or methadone treatment will take weekly semaglutide or a placebo for 12…

This trial explores whether digital tools designed for Asian American clients, along with special training for therapists, can help reduce stress, perfectionism, and symptoms of depression and anxiety. About 80 Asian American adults seeking mental health care will be involved, al…

This trial tests whether digital follow-up through a patient portal and exercise app can help people with mental disorders stick to a 12-week high-intensity interval training program. Participants will be randomly assigned to receive either digital follow-up or standard care, wit…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This study compares two weight-loss strategies: GLP-1 medications (like semaglutide or tirzepatide) versus a structured diet and exercise program. Adults with a BMI of 27.5 or higher are followed for three months to see which approach better improves heart and metabolic markers, …

This study tests whether combining a leadership alignment program with a champion strategy helps clinics in Malawi better integrate mental health care for anxiety and depression. About 1,080 adult patients who screen positive for these conditions will take part. The goal is to se…

This study tests whether cognitive behavioral therapy (CBT) for parents of very premature infants in the NICU can reduce feelings of child vulnerability and improve the child's development. Parents in the intervention group receive five CBT sessions during and after the NICU stay…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study tests a gamified mobile health app designed to reduce suicide risk in adults with mental disorders after they leave the hospital. Researchers will enroll 640 participants in Shenzhen, China, and use game-like features to encourage treatment adherence and follow-up visi…

This study tests whether a 1-month meditation app can help youth on probation (ages 13-20) reduce cannabis use and risky sexual behaviors by improving emotion regulation. Researchers will enroll 300 participants in Cook County, IL, and measure changes in substance use, mood, and …

This study is testing whether virtual reality (VR) training can help people with substance use and mental health disorders improve their social functioning and quality of life. Researchers will compare VR training plus standard care against standard care alone in 102 adults recei…

This study tests a special clinic designed to help people with severe mental illness (like schizophrenia or bipolar disorder) lose weight and improve their metabolic health. About 84 participants will either receive care at this clinic or standard care for 12 months. The main goa…

This large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…

This study tests whether a six-month program of dietary counseling and group exercise can reduce heart disease risk in adults with severe mental illnesses like schizophrenia or bipolar disorder. Around 70 participants will either receive the lifestyle program plus usual care, or …

This study tests a tool called 'Breathlessness diagnostics in a Box' (BiaB) to see if it helps doctors in primary care diagnose the cause of breathlessness faster than usual care. About 900 adults in the Netherlands, Spain, and Portugal will take part. The tool is used during rou…

This study tests two counseling programs—one focused on motivation and coping skills, the other on strengths and advocacy—to prevent opioid misuse in 300 homeless youth aged 14-24. Participants are randomly assigned to one of the programs or standard services, and tracked for two…

This study tests a digital tool called the Family Check-Up Online, designed to prevent family violence and improve child mental health. About 1,270 families with children aged 11-14 will use the program, with some getting extra coach support. Researchers will measure changes in p…

This study tests a program designed to improve well-being and prevent mental health issues in children aged 8-10 and their parents. Over 15,000 families in four European countries will take part. Children attend a mental health day at school, while parents receive either training…

This study tests two self-care methods—virtual ear acupressure and Baduanjin qigong—to prevent or reduce period pain in 145 women aged 16–35 with primary dysmenorrhea. Participants will be randomly assigned to one of three groups and practice their assigned technique for 12 weeks…

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This study tests a support service designed specifically for transgender women, men, and non-binary people in Thailand who have used chemsex drugs or other substances in the past year. The program offers HIV prevention (PrEP), mental health support, and STI care. Researchers will…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study tests whether an 8-week mindfulness program can reduce anxiety and depression in adults with mild emotional distress. Participants are randomly assigned to either mindfulness training or progressive muscle relaxation. Researchers use brain scans to see if mindfulness c…

This trial tests whether a four-week improv comedy program can reduce anxiety and improve mental well-being in Chinese young adults in Hong Kong who have mild-to-moderate anxiety but no diagnosed mental disorder. Participants attend weekly three-hour improv workshops and complete…

This trial tests a program called Teachers Leading the Frontlines (Tealeaf) that trains elementary and middle school teachers in North Carolina to support students with mental health needs, such as depression, anxiety, and behavior challenges. Teachers learn to identify students …

This study tests whether a smartphone app called Bodhi AIM can help youth aged 13–20 who are on probation or in related legal programs improve their psychological wellbeing and reduce distress. Participants use the app for one month, following daily guided meditations. The trial …

This study tests whether a generative AI chatbot can help new mothers learn about pelvic floor health and reduce feelings of loneliness after childbirth. Researchers will compare standard postpartum care with or without access to the chatbot over 4 weeks. The trial involves 130 f…

This trial tests a peer-led program called Honest, Open, Proud (HOP) for veterans with mental health or substance use disorders who have been involved with the justice system. The program helps participants decide whether, when, and how to disclose their conditions, with the goal…

This study tests a digital app called StartHjelp that provides information about mental health treatment, patient rights, and self-help strategies to adults waiting for outpatient care. The goal is to see if using the app improves patient satisfaction, engagement, and knowledge c…

This study tests a smartphone app called AMP-C that teaches people to notice and enjoy positive events. The goal is to see if it can reduce depression and cannabis use in adults who struggle with both. Eighty participants will either use the app or just track their symptoms. The …

This study tests whether a one-week smartphone training program can help unpaid caregivers of people with Alzheimer's disease better manage their emotions. Participants will be randomly assigned to learn one of two emotion-regulation techniques (distancing or reinterpretation) or…

This study tests a 6-week compassion-based program for teens (ages 12-18) with emotional disorders like depression or anxiety, together with their parents. The program includes weekly group sessions and home practice to build self-compassion and improve family communication. Rese…

This study tests whether adding a group-based stabilization and skill-training program to regular individual therapy helps people with long-lasting post-traumatic stress recover better. About 160 adults receiving outpatient mental health care will take part. Half will get the com…

This study tests a therapy called the Unified Protocol, a type of talking therapy designed to help people with emotional disorders like anxiety and depression. About 90 adults will be randomly assigned to receive this therapy, usual care, or be placed on a waitlist. The goal is t…

This study looks at whether Sun Tai Chi, a gentle exercise, can improve mental health (stress, anxiety, depression) and heart function in university students aged 18-29. About 56 students with mild to severe mental health symptoms will either take Tai Chi classes or be in a contr…

This study tests a device that combines magnetic brain stimulation with cognitive exercises to see if it can improve thinking and memory in people with mild Alzheimer's disease. About 180 participants aged 60-85 will receive either real or sham stimulation along with real cogniti…

This study tests a program called SUPERCEDE, which provides intensive case management to veterans who are at risk for suicide and receive care both from the VA and outside community providers. The goal is to improve care coordination, reduce suicidal thoughts, and improve daily f…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study tests an AI chatbot called Aurora that guides people through creating a personal life story to improve emotional well-being and identity. It includes healthy adults, adults with mental health conditions in residential care, and older adults aged 65+. The chatbot is not…

This study looks at whether watching Netflix or Disney shows in a small group for 90 minutes each week, over 6 weeks, can improve emotional awareness and reduce anxiety and depression. About 70 adults who have been in mental health treatment for at least 6 months will take part. …

This study tests whether a weekly skills group is practical and helpful for teens aged 13-18 who are at clinical high risk for psychosis. The group combines two types of therapy to teach coping and social skills. Researchers will track attendance, satisfaction, and quality of lif…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study is testing whether a probiotic supplement called ExoBDNF can improve cognitive abilities like memory and concentration, as well as sleep and mood. About 50 adults aged 18 and older will take the supplement daily for 8 weeks. Researchers will measure changes using quest…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

Researchers are evaluating a flexible and integrative psychiatric care model at Pfalzklinikum in Germany. The model uses a global treatment budget to allow more outpatient and fewer inpatient treatments. The study compares outcomes like hospital stay duration and sick leave days …

This study looks at whether doulas with extra training in mental health support can help pregnant women in rural Montana feel more confident and less depressed. About 75 pregnant women will be split into three groups: one with a specially trained doula, one with a regular doula, …

This trial tests a group-based program called Lev-g, designed to help adults with or without disabilities adopt healthier habits. The program includes three sessions plus a booster, using motivational interviewing and behavioral analysis to support change. Researchers will measur…

This study will test an enhanced version of a suicide safety planning app called ViraSafe in 100 teens and young adults (ages 13-24) who have recently attempted suicide or had serious suicidal thoughts. The goal is to see if the app helps them engage more with coping skills and t…

This study tests whether adding 8 weeks of mindfulness training to a single dose of psilocybin (the active ingredient in magic mushrooms) improves mental health more than psilocybin alone. Forty healthy adults who have never used psychedelics or done formal mindfulness training w…

This observational study follows 300 adults receiving strategic psychotherapy—a short-term, goal-focused talk therapy—in private practice. Participants fill out questionnaires about their symptoms and well-being before and after treatment. The goal is to see if this therapy leads…

This study investigates whether immune inflammation in the blood and brain is linked to brain structure, function, and symptoms in people with schizophrenia. Researchers will follow 200 participants for three months, collecting clinical data, brain scans, and biological samples. …

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study looks at how alcohol and substance use affect people with severe mental illnesses like schizophrenia and bipolar disorder. Researchers compare those who also have substance use problems with those who do not, measuring things like hospitalizations, medication needs, em…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study looks at how the brain processes emotions by using tiny electrical pulses in people with epilepsy who already have electrodes implanted for surgery. Researchers will measure brain activity and physical responses like sweat to understand how certain brain areas control …

This study looks at whether a tool called the Decision Helper helps people with mental health conditions take a more active role in choosing their treatment. About 62 adults in Danish outpatient mental health clinics will have their consultations recorded and analyzed. The goal i…

This study looks at whether giving extra money to lower-income parents for three years can improve their children's mental health and brain function. Researchers will follow 500 children, ages 5 to 14 at the start, and measure stress, inflammation, and brain activity using scans.…

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at how technology, like LEGO robots, can help children with physical disabilities play. Researchers will ask parents and kids about what helps or hinders play, then let children play with robots or conventional toys. The goal is to create a complete model of play…

This study uses powerful 7T MRI scanners and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare brain chemistry and vision in 320 patients and healthy volunteers. The …

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use MRI scans to see if brain areas that control the bladder work differently. They also test if a gentle nerve stimulation treatment (TENS) change…

This study looks at whether creating a personalized profile for children with disruptive behavior and their parents can help predict which treatment will work best. About 200 children and their parents will take part. The goal is to see if matching therapy to a child's specific e…

This study tests whether combining physical activity with a gentle brain stimulation technique (HD-tDCS) can lower anxiety more than either alone. Researchers will measure anxiety levels and brain blood flow in 29 healthy adults aged 18-50. The goal is to understand how these two…

This study looks at how brain structure and gene activity in the blood are linked in people with early schizophrenia. About 1,899 participants, including healthy volunteers, will have brain scans and blood tests at the start and after one year of regular medication. The goal is t…

This study uses a non-invasive brain stimulation technique called TMS to see if it can change brain activity in people with schizophrenia. Researchers will measure brain waves before and after stimulation to understand how the hippocampus works in this condition. The goal is not …

This study looks at the mental health of teenagers aged 11 to 18. Researchers will use questionnaires filled out by teens and their parents to find early signs of emotional or behavioral problems. The goal is to better understand how to detect and help with mental health issues e…

This study follows 80 youth aged 9 to 19 with bipolar disorder across four U.S. sites. Researchers will track mood symptoms, inflammation, and family conflict over 12 months to find what predicts better or worse outcomes. The goal is to create standardized tools and best-practice…

This study is testing whether conversational AI software can effectively collect health information from people with chronic pain. Participants will chat with a digital tool that asks about their physical symptoms, emotions, and social life. The goal is to see if patients find th…

This study looks at whether emotional disorders like depression and anxiety affect how well immunotherapy works in people with liver cancer. Researchers will follow 651 patients and compare treatment outcomes between those with and without emotional distress. The goal is to under…

This study looks at whether a recovery-focused program can help people with severe mental illness living in supported housing. About 72 participants will either receive the new program or standard care. The goal is to see if focusing on personal goals improves daily functioning a…

This study looks at how low oxygen levels (like at high altitudes) affect mood and anxiety in people with depression or anxiety disorders compared to healthy individuals. 68 participants will spend six hours in a special chamber that simulates 3,800 meters altitude, and their fee…

This study tests whether a radio-wave sensor placed in the home can measure sleep, movement, and walking speed in 40 people with mild cognitive impairment or mild Alzheimer's who are taking nicotinamide riboside (a form of vitamin B3). The goal is to find digital biomarkers that …

This pilot study is testing whether a simple saliva test can help doctors prescribe mental health medications more safely and effectively. 200 adults in Manitoba who are starting or changing psychiatric drugs will provide a DNA sample. The results will be shared with their doctor…

This study follows 5,000 children in a Miami-Dade park-based after-school program called Fit2Play. The program includes daily physical activity and nutrition lessons. Researchers will track changes in weight, fitness, blood pressure, and mental health over time to see if the prog…