Irritable bowel syndrome

This study tests whether psyllium fiber bars can help postmenopausal women with irritable bowel syndrome and diarrhea who experience accidental bowel leakage. Researchers will examine changes in gut bacteria and stool chemicals to see if fiber improves symptoms. The study involve…

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This study tested two versions of a low-calorie Mediterranean diet, each with different carb and fat levels, combined with moderate aerobic exercise in 36 adults with obesity and fatty liver disease (NAFLD). The goal was to see if one diet plan worked better than the other at red…

This study looked at whether a diet rich in tomatoes could improve liver health, gut function, and blood sugar in people with non-alcoholic fatty liver disease (NAFLD). Eighty participants either ate a tomato-free diet or one with added tomatoes and sauce for six weeks. Researche…

This study looked at the long-term safety of the drug linaclotide in children aged 6 to 17 with functional constipation or irritable bowel syndrome with constipation (IBS-C). A total of 381 children who had already completed earlier studies took linaclotide for 24 or 52 weeks. Th…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study looked at whether taking probiotic supplements alongside the antibiotic rifaximin helps people with SIBO feel better. 129 adults with bloating or constipation took either probiotics or a placebo for 3 months. The goal was to see if the combination reduced symptoms and …

This study tests whether a 9-week relaxation response mind-body program can improve quality of life and reduce symptoms in people with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). Participants attend weekly group sessions that include breathing exercises, m…

This study explores whether practicing tai chi, a gentle mind-body exercise, can reduce symptoms of irritable bowel syndrome with constipation (IBS-C). Adults aged 18 to 70 with IBS-C will take part in tai chi sessions and report their symptom severity and satisfaction. The goal …

This study tested whether a dietary supplement containing digestive enzymes (Galactol®) could reduce bloating after meals in people with irritable bowel syndrome (IBS). 300 adults were randomly assigned to take the enzyme supplement plus a low-FODMAP diet, or just the diet alone,…

This study tested whether personalized guidance from a dietitian on a low-FODMAP diet works better than just giving patients a standard brochure for managing irritable bowel syndrome (IBS). Fifty adults with IBS followed the diet for 8 weeks. Researchers measured symptom severity…

This study tested a new device called MOWOOT for people with chronic constipation. 86 adults who already used standard treatment (trans-anal irrigation) tried the MOWOOT device to see if it improved their symptoms and quality of life. The goal was to compare the new device's effe…

This pilot study tested whether a digital platform offering two carbohydrate-reduced diets (low FODMAP or low-carb) could help adults with irritable bowel syndrome (IBS). 32 participants used the app for four weeks, reporting their symptoms and quality of life. The goal was to se…

This completed pilot study tested whether electro-acupuncture can improve symptoms of irritable bowel syndrome with constipation (IBS-C). Sixty IBS-C patients were randomly assigned to receive either real electro-acupuncture or a sham (fake) version. The study also collected bloo…

This pilot study tested whether rimegepant (Nurtec), a drug used for migraines, can reduce chronic abdominal pain in people with irritable bowel syndrome (IBS). Thirty-nine adults with non-constipation IBS took either the drug or a placebo for 28 days. Researchers measured change…

This study tested whether a standardized Boswellia extract (a herbal supplement) combined with patient education could reduce symptoms of irritable bowel syndrome (IBS) like belly pain, bloating, and irregular bowel habits. Sixty adults with moderate IBS took the extract twice da…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether ethosuximide, a drug used for epilepsy, can reduce belly pain in people with irritable bowel syndrome (IBS). 162 adults with IBS took either the drug or a placebo. The goal was to see if the drug could lower pain and improve quality of life.

This study looked at whether cutting out certain carbs (FODMAPs) can help people with celiac disease who still have stomach issues even after following a gluten-free diet. Researchers surveyed and then ran a controlled trial with 80 adults who had celiac disease and irritable bow…

This completed trial tested whether a probiotic called Bacillus coagulans can help adults with mild to moderate IBS-D (diarrhea-predominant irritable bowel syndrome). Fifty participants took either the probiotic or a placebo capsule twice daily for 8 weeks. Researchers tracked ch…

This small study tested whether wearing bright light glasses each morning could improve symptoms of irritable bowel syndrome (IBS) and reduce leaky gut. Five adults with IBS used the light device for two weeks. The goal was to see if the light therapy eases belly pain, bloating, …

This study tested three different eating plans in 135 adults with irritable bowel syndrome with diarrhea (IBS-D) to see which best reduces stomach pain, bloating, and other symptoms. Participants followed either a low-FODMAP diet, a Tritordeum-based diet (a special type of wheat)…

This study looked at whether indoor physical activity can improve symptoms in people with both fibromyalgia and irritable bowel syndrome (IBS). Researchers measured changes in gut and pain symptoms, intestinal health, and psychological well-being in 165 participants. The goal was…

This study tested whether a postbiotic supplement can reduce belly pain and other symptoms in people with moderate to severe diarrhea-predominant irritable bowel syndrome (IBS-D). 384 adults aged 18 to 55 took either the postbiotic or a placebo for 12 weeks, then stopped for 3 we…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study tested whether a supplement containing curcumin, green tea, and vitamin D could help control symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D). 78 adults with IBS-D took either the supplement or a placebo for 4 weeks, followed by 4 weeks whe…

This study tested a daily synbiotic supplement (DS-01) in 48 adults with irritable bowel syndrome (IBS) to see if it is safe and helps improve gut health. Participants took either the supplement or a placebo for 12 weeks. The main goal was to check for side effects and see how th…

This study tested whether a low FODMAP diet (limiting certain carbs) can reduce stomach pain and bloating in children with irritable bowel syndrome (IBS). Seventy children aged 4–18 followed either a low or standard FODMAP diet for two weeks, then switched after a break. Research…

This study looked at whether a food supplement containing GABA and Melissa can help improve quality of life and reduce belly discomfort in people with diarrhea-predominant irritable bowel syndrome (IBS-D). Twenty adults with IBS-D took the supplement, and researchers measured cha…

This study looked at whether a low FODMAP diet can improve digestive symptoms in people with irritable bowel syndrome (IBS). Researchers tested 112 adults with IBS, some of whom had a positive breath test for fructose intolerance. The goal was to see if avoiding certain carbohydr…

This study tested if listening to hypnotherapy audio files can help children and teens with stomach pain and bowel problems linked to stress. 32 participants used the audio treatment at home. The goal was to see if this approach is practical and effective, potentially offering a …

This study tested online gut-directed hypnotherapy for adults with irritable bowel syndrome (IBS) whose symptoms did not improve with standard treatments. Fifty participants received group hypnotherapy sessions led by a nurse over the internet. The main goal was to reduce stomach…

This pilot study tested whether varenicline, a drug used to help people quit smoking, can change how the rectum senses pressure in people with irritable bowel syndrome (IBS) who have chronic belly pain. Eight adults with IBS (but not the constipation type) took the drug for 8 day…

This study tested whether plecanatide (Trulance), a drug already approved for adults, can help children aged 6 to 17 with irritable bowel syndrome with constipation (IBS-C). Over 4 weeks, 218 participants took either plecanatide or a placebo daily and tracked their bowel movement…

This study tested whether a low-FODMAP diet—which limits certain carbohydrates that can cause gas and bloating—can reduce symptoms and improve quality of life in people with irritable bowel syndrome (IBS). 183 adults with IBS were split into two groups: one received education on …

This pilot study tested whether a guided imagery therapy mobile app could help children aged 7 to 12 with chronic abdominal pain. Four children listened to 10-15 minute recorded sessions five days a week for eight weeks. The study compared immediate app use to a delayed start gro…

This study tested whether a smartphone app called Zemedy, which delivers cognitive-behavioral therapy, can improve quality of life and reduce symptoms in adults with Irritable Bowel Syndrome (IBS). Over 450 participants used either Zemedy or a relaxation training app for comparis…

This completed trial tested whether a virtual reality program that teaches cognitive behavioral therapy (CBT) can reduce belly pain in people with irritable bowel syndrome (IBS). 73 adults with IBS and significant abdominal pain used either the VR CBT program or a sham VR with na…

This study tested a new diet called 5Ad against the well-known low FODMAP diet in 52 adults with ongoing stomach issues like bloating, pain, and irregular bowel movements. Each person tried both diets for a week, with a break in between. The goal was to see if the 5Ad diet works …

This study tested a non-instrumental biofeedback technique to help people with irritable bowel syndrome or dyspepsia who experience visible abdominal bloating after meals. 41 participants were taught to control their abdominal and chest muscles using a video guide, then practiced…

This study tested a non-invasive brain stimulation technique called rTMS to see if it can reduce chronic visceral pain in people with irritable bowel syndrome with diarrhea (IBS-D). 42 adults with IBS-D received rTMS, and researchers measured changes in pain and bowel symptoms us…

This study looked at whether fructans, a type of carbohydrate found in foods like wheat, onion, and garlic, trigger symptoms in people with irritable bowel syndrome (IBS) with diarrhea. 65 participants followed a low FODMAP diet for 14 days, then reintroduced either fructan or pl…

This study tested whether a daily probiotic powder could relieve irritable bowel syndrome (IBS) symptoms in 80 obese adults. Participants took either the probiotic or a placebo for 8 weeks. Researchers tracked symptom relief and changes in gut bacteria.

This study tested whether gut-directed hypnotherapy (GDH) delivered via telehealth could help manage gastrointestinal symptoms in adults with disorders of gut-brain interaction. Eleven participants completed sessions of general relaxation hypnosis and GDH, plus a 3-month follow-u…

This study looked at whether a home-based audio program of gut-directed hypnotherapy could help children aged 8-18 with irritable bowel syndrome (IBS) or similar belly pain disorders sleep better and feel less pain. 46 children from three hospitals took part; one group used the a…

This study tested whether an online service that provides personalized low-FODMAP menus and nutritional support can improve quality of life and symptoms in people with irritable bowel syndrome (IBS). Forty participants followed the diet for six months using a web platform. Resear…

This small pilot study tested a device that gently stimulates the vagus nerve through the skin in women with irritable bowel syndrome (IBS). Over six months, researchers measured changes in digestion, inflammation, symptoms, and quality of life. The goal was to see if this non-in…

This study looked at 30 adults with Alpha-Gal syndrome, a condition where eating red meat causes allergic reactions. Participants ate cooked ground pork with or without a sugar called alpha-gal, then researchers checked for allergic reactions, gut symptoms, and changes in immune …

This study looked at colon tissue samples from 200 people with irritable bowel syndrome (IBS) to understand why their gut barrier may be leaky. Researchers tested whether substances released by mast cells (a type of immune cell) can damage the gut lining and nerves. The goal is t…

This study looked at how well people with self-reported fiber sensitivity tolerate different doses of soluble fiber. 141 adults took fiber or a placebo for 7 days, and researchers measured digestive symptoms and dropout rates. The goal was to find a dose that causes minimal disco…

This completed Italian study looked at how often children with inactive inflammatory bowel disease (IBD) also have disorders of gut-brain interaction (DGBIs), like irritable bowel syndrome. Researchers used the Rome IV questionnaire to compare 220 children with quiescent IBD to h…

This study measured calprotectin, a protein in stool that signals gut inflammation, in 121 healthy adults aged 22 and older. Participants collected a single stool sample at home and mailed it in. The goal is to establish what level is normal, helping doctors better tell apart inf…

This study looked at 500 women with non-celiac wheat sensitivity (NCWS) to see if they have more gynaecological issues than healthy women or those with celiac disease or irritable bowel syndrome. Researchers also tested whether a gluten-free diet could improve these problems. A s…

This study looked at why certain foods cause symptoms in people with Irritable Bowel Syndrome (IBS). Researchers focused on how gut bacteria produce histamine when digesting specific carbohydrates (FODMAPs). Thirty adults with IBS followed a low-FODMAP diet and took special drink…

This study looked at whether purified gluten or whole wheat (which contains gluten plus other proteins) causes stomach and gut symptoms in people with irritable bowel syndrome (IBS). Twenty-nine adults with IBS who had previously felt better on a gluten-free diet took part. They …

This study looked at 163 children aged 7-12 with chronic abdominal pain to see if simple tests (biomarkers) could predict whether they would benefit more from cognitive behavioral therapy (CBT) or a low FODMAP diet. The goal was to personalize treatment and improve symptoms and q…

This study looked at whether the amount of certain carbohydrates (mannitol and fructans) affects symptom return in people with irritable bowel syndrome (IBS). After a successful low-FODMAP diet, 45 participants were given increasing doses of these powders in a blinded crossover d…

This study looked at how tenapanor, a drug for irritable bowel syndrome with constipation (IBS-C), changes the bacteria and chemicals in the gut. Thirty-six adults took tenapanor twice daily for 8 weeks and provided stool samples. The goal was to understand how the drug works bey…

This study looked at whether insomnia affects pain sensitivity in people with Irritable Bowel Syndrome (IBS). Researchers measured pain thresholds using a barostat procedure in 70 participants, including IBS patients with and without insomnia, healthy volunteers, and people with …

This study looked at whether a simple breath test can help predict which people with diarrhea-predominant irritable bowel syndrome (IBS-D) will respond to the drug rifaximin. 148 participants took rifaximin and completed breath tests and surveys. The goal was to see if the breath…

This study looked at how FODMAPs—carbohydrates that can cause bloating and gas—affect the movement of the colon and related symptoms. Fifteen healthy volunteers received FODMAPs directly into the colon during three separate visits. The goal was to measure colon pressure changes a…

This study looked at nearly 500 people with stomach and bowel problems to see if a low-FODMAP diet helps reduce symptoms. Researchers also checked for joint hypermobility (very flexible joints) and how the gut microbiome might be linked. The goal is to better understand who benef…

This study tested a device that records the electrical signals naturally produced by the stomach, small intestine, and colon. Researchers compared readings from 88 people with and without irritable bowel syndrome (IBS) or other gut issues. The goal was to see if the device could …