Irritable bowel syndrome

This study tests whether taking fecal microbiota transplantation (FMT) pills can improve symptoms of major depressive disorder (MDD) and irritable bowel syndrome (IBS). About 133 adults with MDD, with or without IBS, will either receive FMT or continue their usual treatment. Rese…

This study checks if a new stool test can better tell the difference between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) compared to current tests. About 300 adults and teens will give a stool sample and have a colonoscopy as part of their regular care. If…

This study tests a medicine called tenapanor in children aged 6 to 12 who have irritable bowel syndrome with constipation (IBS-C). The goal is to see if it safely improves bowel movements and reduces belly discomfort. About 72 children will receive either the drug or a placebo fo…

This study is testing the long-term safety of tenapanor (Ibsrela) in children aged 6 to 17 with irritable bowel syndrome with constipation (IBS-C). About 150 kids who completed a prior study will continue taking the drug for up to one year. Researchers will monitor side effects a…

This phase 3 trial tests tenapanor, a drug that helps with constipation and belly pain, in 180 teenagers aged 12 to 17 with irritable bowel syndrome and constipation (IBS-C). Participants take either a low or high dose of tenapanor or a placebo twice daily for 12 weeks. The goal …

This study explores whether individualized transcranial magnetic stimulation (TMS) can improve symptoms in adults with irritable bowel syndrome (IBS). Participants receive 10 TMS sessions over two weeks, with brain scans and stool tests before and after to understand how the trea…

This study compares giving the drug infliximab over 30 minutes versus the standard 60 minutes in children with inflammatory bowel disease (IBD). The goal is to see if the shorter infusion causes just as few allergic reactions and improves patient and nurse satisfaction. Sixty chi…

This study planned to compare a mindfulness-based eating awareness program with the standard low-FODMAP diet for people with irritable bowel syndrome (IBS). The goal was to see which approach better improves IBS symptoms. However, the study was withdrawn before enrolling any part…

This study tests a personalized treatment plan for adults with moderate-to-severe IBS. Participants receive a combination of medical care, dietary guidance, psychological therapy, and physical therapy, chosen in an order that suits them. The goal is to reduce IBS symptoms by at l…

This study tests whether a probiotic called Bifidobacterium longum BBH016 can improve lower gut symptoms like abdominal pain, diarrhea, and bloating. 88 adults with these symptoms but no constipation will take either the probiotic or a placebo capsule twice daily for 8 weeks. Res…

This small pilot study is testing whether psilocybin (the active ingredient in magic mushrooms) given alongside psychotherapy can safely help adults with irritable bowel syndrome (IBS). Fourteen participants will receive two doses of 25 mg of psilocybin in a controlled setting. T…

This study tests whether listening to jazz or reggae music can reduce chronic pain in people with IBS, Crohn's disease, or colitis. Researchers will compare two groups: one listens to mindful jazz, the other to reggae, over four weeks. The goal is to find a safe, non-addictive wa…

This study looks at whether using a 7-inch footstool while on the toilet can improve constipation symptoms. About 85 adults with chronic constipation will use either the real footstool or a very low sham stool for comparison. The goal is to see if the squatting position helps inc…

This study compares two special diets—low FODMAP and a starch-and-sugar-reduced diet—to see which one works better for reducing belly pain, bloating, and other IBS symptoms. About 200 adults with IBS will follow one of the diets and report how they feel. The goal is to find out w…

This study tests whether the donor of a fecal transplant affects IBS symptoms. 500 patients with moderate-to-severe IBS will receive either a placebo (their own stool) or stool from one of three different donors, delivered via a tube into the small intestine. They will track symp…

This study tests a nutraceutical supplement made from pineapple and natural extracts in 94 adults with irritable bowel syndrome (IBS). Participants take the supplement or a placebo daily for 14 days. Researchers track symptom changes using questionnaires and stool tests to see if…

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick …

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This pilot study aimed to see if a new care pathway could help family doctors better diagnose Irritable Bowel Syndrome (IBS) and decide when a specialist is needed. The study was withdrawn before any participants enrolled, so no results are available. It was designed for general …

This study aims to understand how inflammatory bowel disease (IBD) affects patients' quality of life. Researchers will survey 385 adults with Crohn's disease or ulcerative colitis about their symptoms, emotional well-being, and social support. The goal is to identify factors that…

This study looks at how lactose intolerance affects the gut's barrier and inflammation in 200 adults with IBS-like symptoms. Researchers will measure markers in stool samples to see if they relate to symptom severity. The goal is to better understand the link between lactose into…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study looks at whether genetic differences in digesting carbohydrates cause Irritable Bowel Syndrome (IBS) symptoms like belly pain and bloating. Researchers will compare 2000 people with IBS to healthy controls to find how common these gene variants are. The goal is to bett…

This study is creating a registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect medical data, diet and lifestyle questionnaires, and biological samples to explore genetic, microbial, and environmental factors. The goal is t…

This study tests whether non-invasive brain stimulation (rTMS) can alter gut activity in healthy people and those with functional dyspepsia or IBS. Researchers will measure stomach rhythms, heart rate, and fullness thresholds after applying rTMS to the motor cortex. It is an earl…