New drug tested for kids with chronic constipation
NCT ID NCT05905926
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing the long-term safety of tenapanor (Ibsrela) in children aged 6 to 17 with irritable bowel syndrome with constipation (IBS-C). About 150 kids who completed a prior study will continue taking the drug for up to one year. Researchers will monitor side effects and heart health to see if the drug is safe for long-term use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tenapanor (Ibsrela)
What this could lead to
If successful, this could confirm tenapanor as a safe long-term option for managing IBS-C symptoms in children.
What could go wrong
This is an open-label safety study, not a placebo-controlled efficacy trial, so results may not prove how well it works. Side effects are possible, and long-term use in children is still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AIM Trials, LLC
Plano, Texas, 75093, United States
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Advance Clinical Trial PLLC
Abilene, Texas, 79606, United States
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Advanced Research Center, Inc.
Anaheim, California, 92805, United States
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Advantage Clinical Trials
The Bronx, New York, 10467, United States
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Atrium Health
Charlotte, North Carolina, 28203, United States
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Boys Town National Research Hospital
Boys Town, Nebraska, 68010, United States
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Duke University School of Medicine
Durham, North Carolina, 27705, United States
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Florida Pharmaceutical Research and Associates, Inc.
South Miami, Florida, 33143, United States
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Frontier Clinical Research
Kingwood, West Virginia, 26537, United States
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Frontier Clinical Research, LLC
Scottdale, Pennsylvania, 15683, United States
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Frontier Clinical Research, LLC
Smithfield, Pennsylvania, 15478, United States
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G & L Research, LLC
Foley, Alabama, 36535, United States
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I.H.S. Health, LLC
Kissimmee, Florida, 34741, United States
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Maine Health
Portland, Maine, 04102, United States
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Mankato Clinic/ Javara Research Ltd
Mankato, Minnesota, 56001, United States
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Maspons Pediatric Gastro
El Paso, Texas, 79902, United States
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OSF Saint Francis Medical Center
Peoria, Illinois, 61637, United States
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Orlando Health, Inc.- APH Center for Digestive Health and Nutrition
Orlando, Florida, 32806, United States
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Pioneer Research Solutions Inc
Sugar Land, Texas, 77479, United States
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Prisma Health Children's Hospital
Greenville, South Carolina, 29615, United States
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Prohealth Research Center
Doral, Florida, 33166, United States
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Riley Children's Health
Indianapolis, Indiana, 46202, United States
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SUNY Downstate Medical Center
Brooklyn, New York, 11203, United States
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Sun Research Institute
San Antonio, Texas, 78215, United States
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Texas Digestive Specialists
Harlingen, Texas, 78550, United States
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Valencia Medical and Research Center
Miami, Florida, 33165, United States
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Wilmington Health
Wilmington, North Carolina, 28401, United States