Poop pills: does donor selection make or break IBS treatment?

NCT ID NCT06171126

Ongoing Symptom relief Sponsor: Haukeland University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether the donor of a fecal transplant affects IBS symptoms. 500 patients with moderate-to-severe IBS will receive either a placebo (their own stool) or stool from one of three different donors, delivered via a tube into the small intestine. They will track symptoms, quality of life, and gut bacteria changes over a year to see if donor selection leads to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fecal microbiota transplant (FMT) from selected donors
What this could lead to: If successful, this could show that choosing the right donor improves FMT outcomes for IBS, offering a more effective symptom relief option.
What could go wrong: This is a mid-sized trial, but FMT is still experimental for IBS. Results may vary, and long-term benefits or risks are not yet fully known.

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Conditions

The condition(s) this trial relates to.

Dysbiosis Fatigue irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRRITABLE BOWEL SYNDROME

Contacts and locations

Locations

Diakonhjemmet

Oslo, Norway
Haukeland University Hospital

Bergen, Vestland, 5021, Norway
Helse Møre og Romsdal HF

Ålesund, Norway

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