Magic mushroom compound tested for IBS relief
NCT ID NCT06206265
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small pilot study is testing whether psilocybin (the active ingredient in magic mushrooms) given alongside psychotherapy can safely help adults with irritable bowel syndrome (IBS). Fourteen participants will receive two doses of 25 mg of psilocybin in a controlled setting. The study uses a delayed-start design, meaning some people get treatment right away while others wait, to compare effects. The main focus is on safety, but researchers will also track changes in pain, stool habits, and mood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin (TRP-8802)
What this could lead to
If it works, this could point toward a new treatment option for irritable bowel syndrome that combines a psychedelic drug with talk therapy.
What could go wrong
This is a very small, early-phase pilot study with only 14 people. It is designed mainly to test safety, not effectiveness, so results may not apply broadly.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for IRRITABLE BOWEL SYNDROME are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States