Irritable bowel syndrome

This study looks at whether adding a specific probiotic (containing Enterococcus faecium and Bacillus subtilis) to the antibiotic rifaximin can improve treatment for small intestinal bacterial overgrowth (SIBO), a condition that causes bloating, pain, and diarrhea. About 100 adul…

This pilot study from Yale University will test whether listening to calming, instrumental music can reduce pain and stress in people with irritable bowel syndrome (IBS). Thirty adults with moderate IBS pain will listen to pre-recorded playlists for 20 minutes twice a day, five d…

This pilot study compares recorded gut-directed hypnosis to an educational recording for hospitalized patients with chronic gut problems, such as irritable bowel syndrome or inflammatory bowel disease. Participants listen to the recordings over the phone while in the hospital for…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve symptoms and quality of life for adults with constipation-predominant irritable bowel syndrome (IBS-C). Participants use an ear clip for 30 minutes daily over 60 days. The trial c…

This study tests whether an internet-based cognitive behavioral therapy (iCBT) program is feasible and helpful for adults with functional gastrointestinal disorders (FGID), like irritable bowel syndrome (IBS). Thirty participants will complete a 10-week online program with therap…

This study is testing a special probiotic supplement in 30 adults aged 50-65 who have ongoing bowel issues like constipation, irritable bowel syndrome, or stomach pain. The goal is to see if the probiotic can improve gut immunity, balance gut bacteria, and ease symptoms like bloa…

This study tests whether Changji'an capsules, a traditional Chinese medicine, can reduce diarrhea and stomach pain in people with irritable bowel syndrome (IBS) where diarrhea is the main symptom. About 636 adults aged 18 to 65 will take the capsule or a placebo for 8 weeks. The …

This study tests whether a 15-week well-being program can improve mood, reduce IBS symptoms, and boost quality of life in 150 adults with Irritable Bowel Syndrome. Participants will attend weekly one-hour sessions and be followed for up to 9 months. The goal is to see if focusing…

This study tests whether a mobile app can help doctors and dietitians create a personalized low-FODMAP diet for people with Irritable Bowel Syndrome (IBS). About 200 adults with IBS will either use the app or receive a diet booklet. The goal is to reduce stomach pain, bloating, a…

This study tests whether ramosetron, a drug that affects gut serotonin, can improve symptoms in people with diarrhea-predominant IBS. Seventy-six adults aged 18–65 will receive either ramosetron or a placebo daily for four weeks, along with a low-FODMAP diet and lifestyle advice.…

This study tests whether a series of gentle, passive neck movements (called neurodynamic mobilization of the vagus nerve) can reduce symptoms of irritable bowel syndrome (IBS) in women. Thirty-two women aged 20-45 with mild to moderate IBS will receive the treatment for 6 weeks. …

This study looks at whether a relaxation method called autogenic training can reduce symptoms of irritable bowel syndrome (IBS) in adult women. About 44 women with constipation-predominant IBS will practice relaxation exercises and report changes in pain, bowel movements, fatigue…

This study tests whether a 14-day course of the antibiotic rifaximin can reduce bothersome bloating in adults with irritable bowel syndrome, functional constipation, or similar gut disorders. About 78 participants will receive either rifaximin or a placebo, and researchers will m…

This small pilot study will test whether a synbiotic supplement (a mix of probiotics and plant extracts) can improve gut symptoms like bloating, pain, and irregular bowel habits in adults with Irritable Bowel Syndrome (IBS). Eight participants will take the supplement daily for 8…

This study looks at whether a Low-FODMAP diet can help people with irritable bowel syndrome (IBS) by reducing leaky gut, easing symptoms, and improving quality of life. Twenty-four adults with IBS will follow either a Low-FODMAP or a traditional diet for four weeks. Researchers w…

This early study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe irritable bowel syndrome (IBS). Ten adults with hard-to-treat IBS will receive either a high dose of psilocybin or a placebo (niacin) during…

This study tests two doses of linaclotide (72 mcg and 145 mcg) against a placebo in 90 adults with chronic constipation. Participants take the drug daily for 8 weeks and record their bowel movements and symptoms. The goal is to see if linaclotide improves bowel function and reduc…

This study tests whether a small, watch-sized device that delivers mild electrical stimulation to the skin can improve symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D). Researchers will compare the real device to a sham (fake) version in 200 adults ag…

This study looks at whether adding pain neuroscience education to a walking program can reduce abdominal pain, symptom severity, and stress levels in people with irritable bowel syndrome (IBS). Thirty-three adults with IBS will be split into three groups: exercise alone, exercise…

This study tests a diet rich in soluble fiber and natural osmotic sugars (the SOLOS diet) to see if it improves constipation symptoms in adults with functional bowel disorders like IBS-C. Researchers will track stool frequency, form, and symptom severity in 180 participants. The …

This study looks at whether a non-invasive magnetic treatment can help people with constipation-predominant irritable bowel syndrome (IBS-C). About 50 adults aged 18-65 will try functional magnetic therapy to see if it improves constipation, abdominal pain, bloating, and quality …

This early-phase study tests whether a mixture of 157 live bacteria from healthy stool, called MITI 001, is safe for people with diarrhea-predominant irritable bowel syndrome (IBS-D). The goal is to restore healthy gut function and ease symptoms. Only 13 adults with specific sign…

This study tests whether a mobile app that plays guided imagery sessions can help reduce chronic abdominal pain in children aged 7 to 12. Participants listen to 10-15 minute audio sessions five days a week for eight weeks, alongside their usual care. The goal is to see if this ap…

This study looks at whether combining a non-invasive brain stimulation technique called rTMS with either a gut relaxant (pinaverium bromide) or a probiotic (bifidobacteria) can better ease symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D). About 140 adults with ch…

This study looks at whether a new drug called UCB8600 can stop mast cells in the gut from overreacting, which may cause pain in people with irritable bowel syndrome (IBS). Researchers will take gut tissue from 60 people (some with IBS, some healthy) and treat it with UCB8600 in t…

This study looks at how emotional state influences the course of functional dyspepsia and irritable bowel syndrome in 150 adults. Participants will fill out questionnaires about their quality of life, mood, and anxiety at the start and after treatment. The goal is to better under…

This study looks at why some people with irritable bowel syndrome (IBS) feel more belly pain after eating fructose (a sugar found in fruit). Researchers will check the gut bacteria and other body signals in 60 IBS patients. No new treatment is tested — the goal is to better under…

This study will create and test simple picture-based tools (pictograms) to help children aged 8 to 17 describe symptoms like constipation, bloating, and stomach pain. Many kids struggle to explain what they feel, which can lead to misdiagnosis. The goal is to see if these pictogr…

This study will test 70 people with IBS-related diarrhea to see how many actually have lactose intolerance. Researchers will use a PCR test and a symptom questionnaire to find links with age and gender. The goal is to better understand if lactose intolerance is a common, overlook…

This study tests whether a traditional Chinese therapy called umbilical moxibustion (applying heat near the belly button) can help people with irritable bowel syndrome (IBS). Researchers will compare gut bacteria and blood chemicals between 60 patients who receive the therapy and…

This study will check 44 children and teens with inflammatory bowel disease (IBD) for brain, nerve, and psychiatric issues like headaches, seizures, and ADHD. The goal is to catch these problems early to prevent long-term complications. Researchers will screen participants at Ass…

This study will compare the small intestinal bacteria and their byproducts in 90 people with Irritable Bowel Syndrome (IBS) and healthy volunteers. Using special swallowable capsules, researchers will collect samples directly from the small intestine, an area not well studied in …

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…