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Could probiotics help antibiotics work better for gut bacteria overgrowth?

NCT ID NCT07426705

Not yet recruiting Disease control Sponsor: Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding a specific probiotic (containing Enterococcus faecium and Bacillus subtilis) to the antibiotic rifaximin can improve treatment for small intestinal bacterial overgrowth (SIBO), a condition that causes bloating, pain, and diarrhea. About 100 adults with SIBO and irritable bowel syndrome will get either the probiotic or a placebo after antibiotic therapy. The goal is to see if the probiotic helps clear the overgrowth and prevents it from coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
multispecies probiotic containing Enterococcus faecium and Bacillus subtilis
What this could lead to
If it works, this could point toward a way to improve antibiotic treatment for SIBO and lower the chance of symptoms coming back.
What could go wrong
This is a small, early-phase trial with only 100 participants, so results may not apply to everyone. Probiotics can sometimes cause bloating or gas, and the added benefit over antibiotic alone is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome small intestinal bacterial overgrowth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IBS SMALL INTESTINAL BACTERIAL OVERGROWTH SYNDROME (SIBO)

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