Could probiotics help antibiotics work better for gut bacteria overgrowth?
NCT ID NCT07426705
First seen Mar 08, 2026 · Last updated Jun 21, 2026 · Updated 13 times
Summary
This study looks at whether adding a specific probiotic (containing Enterococcus faecium and Bacillus subtilis) to the antibiotic rifaximin can improve treatment for small intestinal bacterial overgrowth (SIBO), a condition that causes bloating, pain, and diarrhea. About 100 adults with SIBO and irritable bowel syndrome will get either the probiotic or a placebo after antibiotic therapy. The goal is to see if the probiotic helps clear the overgrowth and prevents it from coming back.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
multispecies probiotic containing Enterococcus faecium and Bacillus subtilis
What this could lead to
If it works, this could point toward a way to improve antibiotic treatment for SIBO and lower the chance of symptoms coming back.
What could go wrong
This is a small, early-phase trial with only 100 participants, so results may not apply to everyone. Probiotics can sometimes cause bloating or gas, and the added benefit over antibiotic alone is uncertain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.