Disorder of pilosebaceous unit

This study tests an mRNA vaccine designed to fight acne. Researchers will give two shots to 120 adults aged 18 to 45 with mild acne. The goal is to see if the vaccine is safe and reduces pimples. Participants are randomly assigned to receive the vaccine or a placebo.

This study tests a drug called deuruxolitinib in Japanese adults aged 18-65 with severe alopecia areata, an autoimmune condition causing significant scalp hair loss. Participants must have at least 50% hair loss. The trial measures how well the drug regrows hair and how satisfied…

This phase 3 trial tests whether upadacitinib (Rinvoq) can help regrow hair in people with severe alopecia areata, an autoimmune condition that causes patchy or total hair loss. About 1500 adults and teens will receive either the drug or a placebo daily for up to 160 weeks. The m…

This study tests whether transplanting healthy gut bacteria can help people with alopecia areata, an autoimmune disease that causes patchy or total hair loss. Forty adults with moderate to severe hair loss will take either antibiotic and microbiota transplant capsules or a placeb…

This study tests a new drug called LY4005130 for adults with severe alopecia areata, a condition causing significant hair loss. About 60 participants will receive either the drug or a placebo intravenously. The goal is to see if the drug can regrow hair and to check for side effe…

This phase 2 trial tests whether ruxolitinib, a drug already approved for certain blood disorders, can help regrow hair in people with APECED, a rare immune condition that often causes severe alopecia areata. About 70 participants aged 12 to 75 will take the pill twice daily for …

This study tests whether dupilumab, a drug used for allergies and eczema, can help regrow hair in people with moderate-to-severe alopecia areata who also have allergies or high IgE levels. Participants receive weekly injections of dupilumab or a placebo for 48 weeks, followed by …

This study tests whether a special shampoo regimen can improve scalp health and reduce dandruff in 120 Chinese men who have had hair transplants. Some participants have mild-to-moderate seborrheic dermatitis (a common dandruff condition). The test group uses a special shampoo plu…

This study tests a daily pill called deucravacitinib in 20 adults with two types of scarring hair loss (CCCA and FFA). The goal is to see if it can reduce inflammation and scarring on the scalp over 48 weeks. All participants receive the drug, and researchers will measure changes…

This pilot study tests a 1470nm laser on 10 adults with androgenetic alopecia (common baldness) or scarring alopecia. Researchers will measure hair density and counts using imaging, and track satisfaction. The goal is to see if the laser is safe and can improve hair growth.

This pilot study tests a topical cream called delgocitinib in 30 adults with two types of scarring hair loss: lichen planopilaris and central centrifugal cicatricial alopecia. Participants apply the cream twice daily for 48 weeks. The study focuses on safety and changes in immune…

This study tests a new treatment called EPI-001 for androgenetic alopecia (common baldness). EPI-001 is made from a patient's own scalp cells and injected into the scalp. The trial has two parts: first, finding the safest dose in a small group, then comparing the best dose to a p…

This study follows 850 people with alopecia areata who are taking the approved drug ritlecitinib in real-world clinics. Researchers will measure hair regrowth using the SALT score over 24 weeks. The goal is to see how well the drug works outside of controlled trials, in everyday …

This study is testing a device called Ultra that uses low-level laser light to help hair grow back. It involves 44 adults aged 22 to 70 with male or female pattern baldness. Participants will receive six laser treatments on their scalp, two weeks apart, and researchers will check…

This early-stage trial tests whether ABS-201, an antibody that blocks a hormone receptor, is safe for treating hair loss. It starts with healthy volunteers and then includes people with male or female pattern baldness. Participants receive either the drug or a placebo and are mon…

This study compares giving oral isotretinoin (a strong acne medication) right away versus the usual antibiotics for moderate acne in people with darker skin (Fitzpatrick types IV-VI). The goal is to see if early use of isotretinoin reduces acne-related dark spots better than stan…

This study tests whether baricitinib, a daily pill, can safely regrow hair in children aged 6 to 17 with severe alopecia areata (patchy hair loss). About 595 kids will receive either the drug or a placebo for 36 weeks, then all can get the drug for up to 2 years. The goal is to s…

This study tests a drug called LAD603 in 136 adults with severe to very severe alopecia areata, a condition causing significant hair loss. Participants will receive either the drug or a placebo to see if it helps regrow hair and is safe. The main goal is to measure changes in hai…

This study is monitoring the safety and effectiveness of Litfulo (Ritlecitinib) in 3,000 people with severe alopecia areata, a condition causing patchy hair loss. Participants take the drug as prescribed in real-world clinics across Korea. Researchers will track side effects and …

This study compares a weekly dose of isotretinoin (a vitamin A derivative) to daily tetracycline antibiotics for treating moderate acne. Researchers want to see if the weekly approach works just as well, with fewer side effects and less reliance on antibiotics. The trial will enr…

This study compares a new peptide-based hair serum to the standard treatment minoxidil for people with pattern baldness. About 80 adults with mild to moderate hair loss will use one of the two treatments for 24 weeks. Researchers will measure changes in hair density and thickness…

This phase 3 trial tests whether a daily 1 mg minoxidil pill can treat female pattern hair loss as effectively as the standard topical minoxidil solution. About 520 women with hair thinning will be randomly assigned to receive either the oral pill, the topical solution, or a plac…

This study tests an experimental mRNA vaccine designed to treat moderate to severe acne in adults aged 18 to 45. The vaccine is given as up to three injections into the muscle. Researchers will monitor safety, immune response, and how well it reduces acne lesions. The trial invol…

This study looks at the long-term safety and effects of the drug ritlecitinib for severe alopecia areata, a condition causing significant hair loss. It involves 140 teens who previously completed Pfizer studies on this drug. Participants take a daily capsule for up to 3 years, wi…

This early-stage trial tests a new drug called IBI3013, which blocks a protein (IL-15) involved in immune attacks. It includes 160 people: healthy volunteers first, then people with active vitiligo or severe alopecia areata. The main goal is to check safety and how the drug moves…

This study tests an oral medication called brepocitinib for adults with lichen planopilaris, a condition that causes scalp inflammation, scarring, and hair loss. About 342 participants will receive either the drug or a placebo to see if it reduces symptoms and improves scalp appe…

This study is testing whether combining platelet-rich plasma (PRP) with Botox injections works better than PRP alone for treating androgenetic alopecia (common pattern baldness). About 76 adults aged 18 to 60 with mild to moderate hair loss will receive either the combo treatment…

This study tests an experimental oral drug called NXC736 in 73 adults with moderate to severe alopecia areata, a condition causing patchy or total hair loss. Participants are randomly assigned to receive either NXC736 or a placebo for 12 weeks. The main goal is to see if the drug…

This study tests a cream made from a common probiotic, Lactobacillus reuteri, that has been coated with a special material to help it survive on the skin. The goal is to see if it can rebalance the skin's bacteria and reduce acne. About 196 people with mild to moderate acne will …

This study tests whether applying a probiotic (Lactobacillus reuteri) to the scalp daily for 12 months can safely increase hair density in people with androgenetic alopecia (male or female pattern baldness). About 388 adults aged 18-60 will be randomly assigned to receive the act…

This study tests whether giving a Chinese herbal medicine called Realgar-Indigo naturalis formula (RIF) together with standard vitamin A therapy right away can lower the risk of early death in people with a fast-growing blood cancer called acute promyelocytic leukemia (APL). Abou…

This study looks at 250 African-American women with a type of scarring hair loss called CCCA. Researchers will compare how well different treatments—like steroid creams, steroid injections, an oral antibiotic, and minoxidil—work over 18 months. The goal is to see which approach b…

This study tests a new drug called BG-A3004 for the first time in humans. It aims to check the drug's safety and how the body processes it in healthy volunteers and people with immune-related skin diseases. The study is split into two parts: single dose in healthy people and mult…

This Phase 3 trial tests a new topical solution called TH07 for male pattern baldness. It combines three active ingredients (minoxidil, finasteride, and latanoprost) to see if it grows more hair than standard minoxidil or a placebo. 420 men aged 18-49 with moderate hair loss will…

This study tests an experimental drug called OLX72021 in 158 men with mild to moderate male pattern baldness. The drug is injected into the scalp at different doses to see if it is safe and can increase hair count compared to a placebo. The trial is currently recruiting participa…

This study tests if a once-daily 5% minoxidil foam can help women with androgenetic alopecia (female pattern hair loss) grow more hair. About 294 women aged 18 and older with mild to moderate hair loss will use either the foam or a placebo for 24 weeks. The main goal is to see if…

This study tests an experimental eye drop called GLK-321 in 250 adults with Demodex blepharitis, a condition where tiny mites cause debris at the base of eyelashes. Participants will receive either a low, mid, or high dose of the drug, or a placebo, for 6 weeks. The main goal is …

This study tests whether injections of secretome (a substance made by stem cells) or platelet-rich plasma (PRP) can improve hair density and thickness in people with androgenetic alopecia (common baldness). Forty men and women with mild to moderate hair loss will receive injectio…

This study tests if dupilumab can help children aged 6 to 17 with moderate to severe alopecia areata regrow hair. About 76 participants will receive either the drug or a placebo for 48 weeks, followed by an open-label extension. The main goal is to measure changes in scalp hair l…

This study tests a treatment called autologous hair follicle secretome (aHFS) for androgenic alopecia (common baldness). The treatment is made by taking hair follicles from the person, growing them in a lab, and collecting the substances they release. These are then injected into…

This pilot study tests nemolizumab, a drug already approved for other skin conditions, in 10 adults with lichen planopilaris (LPP), a disease that causes permanent hair loss and scalp itching or burning. The goal is to see if the drug can reduce disease activity and improve sympt…

This study tests a daily pill called abrocitinib for people with Down syndrome who have eczema or a type of hair loss. About 56 participants will take the drug for up to 60 weeks to see if it safely controls their skin or scalp condition. The goal is to manage symptoms, not cure …

This study compares two common drugs, cyclosporine and methotrexate, to treat moderate-to-severe alopecia areata in children aged 2-17. The goal is to see which medicine helps regrow hair better over 9 months. Participants and their parents choose which treatment to try, and doct…

This study tests whether tiny particles from stem cells (exosomes) can safely help regrow hair in men with androgenic alopecia (male pattern baldness). The exosomes are delivered into the scalp using a microneedle device. The trial will enroll 18 men aged 18 to 60 with mild to mo…

This study tests an oral drug called deuruxolitinib in teenagers aged 12 to 17 who have lost at least half their scalp hair due to alopecia areata. The goal is to see if the drug can safely regrow hair. Participants will be randomly assigned to receive either the drug or a placeb…

This study tests whether microneedling combined with one of three substances—lactic acid, vitamin D3, or a steroid (triamcinolone acetonide)—can help regrow hair in people with patchy alopecia areata. Eighty-eight participants will receive one of the four treatments (including a …

This study tests whether cold atmospheric plasma (CAP) can safely and effectively treat moderate-to-severe acne. 220 adults aged 18-40 will receive either CAP or a placebo treatment once a week for six weeks. The goal is to see if CAP reduces acne lesions better than placebo, off…

This study tests a daily pill called upadacitinib for people with severe alopecia areata, an immune system attack on hair follicles causing at least 25% scalp hair loss. About 123 teens and adults in Japan will take either the drug or a placebo for up to 104 weeks to see if it sa…

This Phase 3 trial tests a new hair lotion called Finlândia for male pattern baldness. About 190 men aged 18-60 with moderate hair loss will use the lotion or a standard treatment for 6 months. The main goal is to see if it increases hair density on the scalp.

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This study tests whether a treatment made from umbilical cord stem cell exosomes can help young men with male pattern baldness grow thicker, fuller hair. About 59 men aged 18-35 will receive either the exosome injections or standard minoxidil lotion. The goal is to see if the exo…

This early study tests a new device called the LuSeed Aneurysm Embolization System for treating unruptured brain aneurysms. The device is designed to block blood flow into the aneurysm, reducing the risk of rupture. About 30 adults aged 18-80 with unruptured saccular aneurysms wi…

This study tests an oral drug called VDPHL01 in 552 women aged 18–65 with mild to moderate hereditary hair loss. Participants take a pill once or twice daily for about 13 months. The goal is to see if it increases hair count and if women feel their hair looks better. It's a place…

This early-stage trial tests a drug called FB102 in 32 adults with severe to very severe alopecia areata, a condition causing significant hair loss. Half receive the drug and half a placebo, all by IV. The main goal is to check safety, but researchers will also measure hair regro…

This program provides early access to ritlecitinib for people with severe alopecia areata who have lost at least half of their scalp hair and have not responded to or cannot tolerate standard treatments. The goal is to offer a potential treatment option before the drug is fully a…

This early-stage study tests a new drug called HCW9302 in 30 adults with alopecia areata, a condition causing patchy or total hair loss. The drug is an IL-2 fusion protein given by injection. The main goal is to check safety and find the right dose for future studies, not to prov…

This early-stage trial tests a new drug called VIS171 in 30 people with lupus, alopecia areata, or a kidney condition called FSGS. The main goal is to check safety and how the body handles the drug. Participants receive VIS171 as a shot under the skin, alongside their usual care,…

This pilot study tests whether injecting cyclosporine directly into the scalp can safely regrow hair in people with alopecia areata, an autoimmune disease causing patchy hair loss. Twelve adults with mild to moderate hair loss will receive either cyclosporine or saline injections…

This study tests whether a special cooling cap can reduce hair loss in people with metastatic breast cancer who are receiving certain chemotherapy drugs. About 120 participants will either use the Paxman Scalp Cooling System or not, and researchers will compare hair loss rates an…

This early-stage trial tests an experimental oral drug called TVB-3567 in 128 healthy adults, some with acne. The main goal is to check safety and how the body processes the drug, not yet whether it works. Results will help decide if larger studies are warranted.

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study tests whether a special cooling cap can prevent hair loss in children receiving chemotherapy for non-cancerous conditions or solid tumors. The cap is worn before, during, and after chemo to keep the scalp cool. Researchers want to see if it is safe and tolerable for 40…

This study tests a new gel (2-Deoxy-D-ribose) against the standard hair loss treatment, minoxidil, in 60 adults aged 18 to 50 with mild to moderate hair loss. Participants will apply either the gel or minoxidil to their scalp daily for 6 months. The goal is to see which treatment…

This study tests if timolol eye drops, applied as a cream, can reduce the red marks left after acne. It compares the drops to intense pulsed light (IPL) therapy in 60 people aged 12 and older. The goal is to see if a simple, low-cost option can work as well as a laser treatment.

This study tests a daily drinkable supplement called Olistic Next Women to see if it can reduce hair loss in women over 35 who are taking GLP-1/GIP weight-loss drugs. Forty participants will be randomly assigned to receive either the supplement or a placebo for 6 months. The main…

This early trial tests whether minoxidil (Rogaine) — applied to the scalp or taken as a pill — can help with hair loss caused by hormone therapy in breast cancer patients. About 50 women with stage I-IV breast cancer who report hair thinning since starting endocrine therapy will …

This small pilot study tests whether a special red LED cap can improve symptoms and slow hair loss in women with central centrifugal cicatricial alopecia (CCCA), a scarring hair loss that mainly affects middle-aged Black women. Five women with confirmed CCCA will use the cap dail…

This early-stage study tests whether ALD-102, a solution injected into the scalp, is safe and can help regrow hair in people with alopecia areata. About 24 adults aged 18-55 will receive either the drug, a placebo (saline), or no treatment in different scalp areas. The main goal …

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This study tests a special cooling cap worn during chemotherapy to see if it helps breast cancer patients keep more of their hair and feel better emotionally. About 100 people with early-stage breast cancer will take part. Researchers will also look at certain genes to see if the…

This study is testing a new laser called PALLAS to treat skin diseases like vitiligo, psoriasis, alopecia areata, and atopic dermatitis. About 50 people will receive UVB laser treatments twice a week for up to 3 months. The goal is to see if the laser improves the skin condition …

This study tests a daily supplement called Olistic Next Women in 60 women aged 45-65 who are starting to lose hair. For 6 months, some women get the supplement and others get a placebo. Researchers will measure hair density and shedding to see if the supplement helps without caus…

This study tests a laser device called FoLix to improve hair loss in 40 adults with darker skin (Fitzpatrick types V-VI). Participants will receive 4 treatments, one month apart. Researchers will compare before-and-after photos and hair counts to see if the laser helps hair grow …

This study tests whether a daily supplement called Olistic Next Women can improve hair growth and reduce hair loss in women aged 50-65 who are starting to experience female pattern hair loss. Over 6 months, 100 women will take either the supplement or a placebo, and researchers w…

This study is testing whether a special non-ablative laser can help treat scarring alopecia, a condition that causes permanent hair loss. Five adults will receive three laser treatments and attend follow-up visits over 15 months. Researchers will also study hair follicle genes to…

This study tests a cream called trifarotene on Chinese people aged 9 and older with moderate acne on the face and upper body. About 561 participants will apply the cream or a placebo daily for 12 weeks. The goal is to see if the cream reduces acne lesions and improves skin appear…

This study tests whether a daily 300 mg capsule of KSM-66 Ashwagandha, an herbal supplement, can improve skin and hair health in 50 healthy adults over 12 weeks. Participants are randomly assigned to receive either the supplement or a placebo, and neither they nor the researchers…

This early-phase trial tests a topical phenylephrine gel applied daily to the scalp for three weeks. Researchers want to see how much of the drug enters the bloodstream and whether it is safe. The study involves 24 healthy women aged 18-55, not cancer patients, so it is a first s…

This 6-month study tests whether oral capsules and a hair tonic made from traditional Chinese medicine can help with hair loss and graying. 152 adults with hair loss (some with gray hair) will be randomly assigned to receive the active treatment or a placebo. Researchers will mea…

This study looks at whether isotretinoin, a common acne medicine, changes how well people can smell. Researchers will test the sense of smell in 54 adults before and after at least 4 weeks of treatment. The goal is to understand if the drug's drying effect on the nose can reduce …

This study aims to understand why hair follicles stop working in male pattern baldness. Researchers will collect scalp samples from 12 men (younger and older) with and without hair loss. Using advanced technology, they will map cells and genes to find key targets for future treat…

This study will measure a protein called JAK2 in the scalps of 25 people with male pattern baldness. Researchers will compare JAK2 levels in balding and non-balding areas, then see if 12 weeks of topical minoxidil 5% changes JAK2 in the balding scalp. The goal is to understand wh…

This study looks at how two common acne antibiotics, sarecycline and doxycycline, change the bacteria living in your gut and on your skin. Researchers will track these changes in 30 people with acne over the treatment period. The goal is to understand which antibiotic is gentler …

This study is creating a group of 200 acne patients at Nantes University Hospital to learn more about the disease. Researchers will track factors like acne severity, quality of life, and treatment costs, and collect skin samples. The goal is to better understand what makes acne w…

This study collects skin samples from 500 people with conditions like acne, eczema, and psoriasis, as well as healthy volunteers. Researchers will analyze the samples to find biomarkers and gene patterns linked to inflammation. The goal is to better understand these skin diseases…

This study is testing whether a cream made from a person's own hair follicles can reduce redness, swelling, and downtime after medical aesthetic procedures like laser treatments or facelifts. Researchers will follow 500 adults aged 18 to 60 who are planning such a procedure. The …

This study aims to understand how alopecia areata, vitiligo, and hidradenitis suppurativa affect the quality of life and daily functioning of teenagers and adults. Researchers will collect information from nearly 2,800 participants across multiple countries using surveys and skin…

This study looks at how severe obesity and weight-loss surgery change natural chemicals in scalp hair. Researchers will track 60 adults—some with severe obesity scheduled for bariatric surgery and some healthy-weight controls—to see if hair chemistry can signal poor metabolic hea…

This registry will follow 1500 adolescents aged 12-17 with severe alopecia areata, a condition causing hair loss. Researchers will collect data from routine dermatology visits to better understand the disease's natural history, how it is managed, and what treatments are used. The…

This observational study will follow about 5,000 adults with alopecia areata across North America to learn more about the condition, how it changes over time, and how it is currently treated. Researchers will collect data from doctor visits and patient surveys to better understan…

This study tests two different preparation designs (bevel vs. butt) for Peek endocrowns, which are tooth-colored caps for molars that have had root canals. Researchers will check how precisely each design fits the tooth, using a replica technique and microscope. The goal is to se…