Disorder of pilosebaceous unit

This study investigates whether clascoterone cream 1%, an FDA-approved acne medication, works by reducing sebum (skin oil) production. Researchers will measure forehead oil levels and changes in skin bacteria in 40 participants aged 12 and older with mild to moderate acne. The go…

This Phase 3 study tested a topical solution called clascoterone in 703 men with mild to moderate male pattern baldness. Participants applied the solution or a placebo to their scalp twice daily for 6 months, and some continued for another 6 months. The goal was to see if clascot…

This study tested a special mineral-ionic formula called THERAVEX REGENERA in 20 adults with hair loss. The treatment was used during hair transplant procedures and as a scalp therapy to help hair follicles grow back. Researchers checked safety and measured changes in hair densit…

This completed trial tested whether adding vitamin D supplements to standard acne treatment (azithromycin and a topical retinoid) improves acne more than standard treatment alone. Fifty-eight people aged 13 to 40 with acne vulgaris took part. The main goal was to see if the combi…

This study tested a new drug (PF-06700841) in 51 adults with cicatricial alopecia, a type of hair loss that destroys hair follicles and leaves scars. The main goals were to check the drug's safety and see how it affects certain genes in the skin and blood. Researchers hope this w…

This study tested a new way to take minoxidil for male pattern baldness: a tablet placed under the tongue. 142 men with moderate to severe hair loss took either the minoxidil tablet or a placebo twice daily for 24 weeks. The goal was to see if this method increases hair count and…

This study tested whether millet seed extract capsules can reduce hair shedding in women with telogen effluvium, a common temporary hair loss condition. Sixty women took either the millet seed supplement or biotin alone for 12 weeks. Researchers measured changes in hair density u…

This study tested special clothing made with Lumiton yarn that captures sunlight and turns it into red and near-infrared light, aiming to improve skin conditions like psoriasis, alopecia areata, and polymorphous light eruption. Eighteen adults with mild-to-severe forms of these c…

This study tested whether injecting platelet-rich plasma (PRP) into the scalp, along with using minoxidil lotion, can improve hair growth in people with moderate to severe androgenetic alopecia (common baldness). Thirty participants were split into two groups: one received PRP in…

This study tested baricitinib, an anti-inflammatory pill, in 784 adults with severe or very severe alopecia areata, a condition causing extensive hair loss. Participants received either baricitinib or a placebo for up to 52 weeks. The main goal was to see if baricitinib could reg…

This study tested a drug called PF-06651600 in over 1,000 adults and teenagers with alopecia areata, a condition that causes patchy or complete hair loss. The goal was to see if the drug is safe and helps hair grow back over the long term. A smaller group also checked how well th…

This study tested the drug baricitinib in 606 adults with severe or very severe alopecia areata, a condition causing significant hair loss. Participants took either baricitinib or a placebo pill daily for up to 36 weeks. The main goal was to see if baricitinib could regrow enough…

This Phase 3 trial tested whether low doses of interleukin-2 (IL2) can help people with severe alopecia areata, a condition causing patchy or total hair loss. 44 adults with at least 50% scalp hair loss who had not responded to other treatments received either IL2 injections or a…

This completed Phase 1 trial compared a generic tretinoin gel (0.04%) to the brand-name RETIN-A MICRO for treating acne vulgaris. Over 1,000 participants aged 12 to 40 with mild to moderate acne applied the gel daily for 12 weeks. The goal was to see if the generic version works …

This study tested whether cleaning the eyelids with wipes containing chlorhexidine can treat blepharitis caused by Demodex mites. 106 adults with the condition used the wipes twice daily for four weeks. Researchers measured mite counts and eyelash debris before and after treatmen…

This study tested a new medication called CG2001 for male pattern baldness in Chinese men aged 18 to 65. The goal was to see if it helps regrow hair and is safe to use. The trial involved 110 participants and measured changes in hair count after 24 weeks.

This early-stage trial tested a drug called IMG-007 in 29 adults with alopecia areata who had lost at least half of their scalp hair. The main goal was to check safety, but researchers also measured hair regrowth using a standard tool. The study is now complete, and results will …

This study tested whether a dietary supplement (capsules and drink) could reduce hair loss in 240 adults with androgenetic alopecia or chronic telogen effluvium. Participants took the supplement or a placebo daily for 6 months. Researchers measured hair density and asked about pr…

This study tested whether injecting a person's own concentrated platelets (PRP) into the scalp can improve hair growth in men with male pattern baldness. Two hundred one men received 3 to 5 sessions of PRP injections. The main goal was to see if hair loss grade improved based on …

This study tested the acne cream Winlevi in 10 people with darker skin tones (Fitzpatrick types IV, V, VI). The goal was to see how well it cleared or nearly cleared acne after 16 weeks. Acne is very common, but there is little research focused on skin of color, so this study hel…

This study tested a daily supplement called Olistic Next Women in 39 women aged 50-65 with early female pattern hair loss. Over 6 months, researchers measured changes in hair density and shedding. The goal was to see if the supplement could help control hair thinning without chan…

This Phase 3 trial tested a topical solution called clascoterone for male pattern hair loss. 762 men with mild to moderate balding applied the solution or a placebo twice daily for 6 months, followed by another 6 months for those who responded. The goal was to see if clascoterone…

This completed trial tested two different cumulative doses of the acne drug Roaccutane (120 mg/kg vs 150 mg/kg) in 91 people with severe cystic acne. Researchers measured how well each dose reduced acne lesions and severity, and tracked whether acne returned within a year. The go…

This early-stage trial tested the safety of a new topical gel called AH-001 in 64 healthy volunteers and men with male pattern baldness. Participants received either a single dose or daily doses for a week of the gel or a placebo. The study focused on side effects and how the dru…

This study tested a gel called PP405 for male and female pattern baldness. 78 adults used the gel or a placebo for 28 days, then everyone could use the real gel for 3 more months. The main goals were to check safety and how the body processes the drug.

This 6-month study tested a daily drinkable supplement containing vitamins, minerals, and plant extracts in 106 women aged 18-40 with telogen effluvium (a common temporary hair loss). Half took the supplement, half took a placebo. Researchers measured hair density and growth cycl…

This study tested whether tofacitinib, a drug already approved for arthritis, is safe and helpful for immune-related skin conditions in people with Down syndrome. 47 adolescents and adults with Down syndrome and skin issues like eczema or psoriasis took the drug. Researchers chec…

This completed study tested whether applying a dextrose (sugar) gel with ultrasound, called phonophoresis, can improve mild to moderate acne. 115 people aged 18 to 30 with acne took part. The goal was to see if this approach reduces acne lesions and severity.

This study tested the long-term safety of a daily pill called ASC40 (Denifanstat) in 240 people with moderate to severe acne who had already completed a previous phase 3 trial. Participants took the drug once daily for up to 40 weeks, with regular blood tests and checkups to moni…

This study tested the long-term safety and effectiveness of a drug called CTP-543 in 407 adults with moderate to severe alopecia areata, a condition that causes patchy or complete hair loss. Participants had already completed 24 weeks of treatment in a previous trial. The goal wa…

This study tested three types of chemical peels—50% glycolic acid, 30% salicylic acid, and modified Jessner's—on 90 adults with mild to moderate facial acne and post-acne dark spots. Participants received one type of peel, and doctors measured improvements in acne severity and pi…

This phase 2 trial tested a new drug called TDM-105795 for male pattern baldness. 71 men with mild to moderate hair loss applied a solution to their scalp every day for 16 weeks. The study measured hair count and hair width to see if the treatment helped regrow hair.

This study tested a combination of two acne treatments—Winlevi (a hormone-blocking cream) and adapalene 0.3% gel—to see how well they work together in real-life use. Twenty people with acne used both treatments for 16 weeks. The main goal was to see how many achieved clear or alm…

This study tested an eyedrop called TP-03 in 39 people with meibomian gland dysfunction (a common cause of dry eye) linked to Demodex mites. The goal was to compare two dosing schedules (twice vs. three times daily) for safety and effectiveness. The results could lead to a new tr…

This Phase 2 trial tested a drug called imsidolimab (ANB019) in 123 people with moderate to severe acne. The drug is a lab-made antibody designed to reduce inflammation. Researchers measured how much facial acne lesions decreased over 12 weeks compared to a placebo. The goal is t…

This completed trial tested whether an oral anti-inflammatory drug called roflumilast can regrow hair as well as steroid injections in people with mild-to-moderate patchy alopecia areata. Fifty adults with limited to moderate hair loss were enrolled. The main goal was to measure …

This completed study tested a new hair growth serum called SesZen-Bio against a standard treatment (minoxidil 1%) and a placebo in 108 adults with mild to moderate androgenic alopecia (male or female pattern baldness). Participants applied the serum daily to their scalp for sever…

This study tested whether adding the antibiotic rifampicin to the standard antiseptic povidone-iodine could improve wound healing and prevent infection after hair transplantation. 65 adults were randomly assigned to receive either the combination or the standard antiseptic alone.…

This study tested whether an artificial intelligence tool called Legit Health Plus can help doctors track the severity of chronic skin conditions like acne, psoriasis, and eczema from a distance. 160 participants used a smartphone app for 6 months to take photos of their skin and…

This completed study tested whether an AI device could help 16 doctors (10 general practitioners and 6 dermatologists) more accurately diagnose 13 different skin conditions, including melanoma, psoriasis, and acne. The doctors reviewed 29 medical images, first giving a diagnosis …

This study tested a once-daily scalp serum on 57 women aged 25 to 65 with mild to moderate hair thinning. Over 12 weeks, researchers used special imaging to measure hair density and thickness, and also checked scalp health. The goal was to see if the serum could help hair look fu…

This pilot study tested a scalp cooling device (Paxman) to prevent hair loss in 9 people with advanced pancreatic cancer receiving chemotherapy. The goal was to see if the cap could keep hair loss mild (less than 50% hair loss) and improve comfort. Results focused on hair preserv…

This study tested a gel containing dapsone (7.5%) against a placebo gel in 100 adults with mild-to-moderate acne. Participants applied the gel once daily for 8 weeks, and researchers tracked changes in acne lesions, skin oil, redness, and quality of life. The goal was to see if t…

This study tested a laser device (NIRA Laser M2.1) on 120 adults aged 35 and older to see if it could safely reduce full-face wrinkles. Some participants also used a topical cream after the laser. Wrinkle improvement was judged by experts looking at before-and-after photos, and p…

This study tested whether wearing special cold caps (Penguin caps) during chemotherapy could prevent or reduce hair loss in people with early-stage breast cancer. Twelve participants used the caps while getting one of four common chemo regimens. The goal was to see if at least ha…

This study looked at whether placing a white cover over the incubator and giving gentle massage during phototherapy can lower bilirubin levels faster in newborns with jaundice caused by ABO incompatibility. Sixty full-term babies were included. The goal was to see if these simple…

This study tested a cream paste containing pleuran (a beta-glucan from oyster mushrooms) on 110 children with diaper rash, perioral dermatitis, or neonatal pustulosis. Participants applied the cream 2-3 times daily for up to 2 weeks without other treatments. Researchers measured …

This study tested a home-use helmet that shines low-level light on the scalp to help hair regrow after chemotherapy. 106 women with breast cancer who had just finished chemo used the device three times a week for four weeks. Researchers measured hair count and width, and tracked …

This study tested whether a cream made from icariin, a plant compound, can improve acne and reduce acne scars. Twenty-five adults applied the cream or a control solution to their face twice daily for two months. The goal was to see if it lowers the number of pimples and scars and…

This study tested a special shampoo for people with hair loss from telogen effluvium or early male/female pattern baldness. 40 adults used the shampoo for 3 months. The goal was to see if it improved hair length and thickness. The study is now complete.

This study tested whether applying a cosmetic ingredient called latanoprost acid to the scalp could improve hair growth in women aged 18-60 with female pattern hair loss or chronic telogen effluvium. Twenty-nine women used one of three strengths of the product daily for six month…

This study tested a dietary supplement containing biotin, collagen, keratin, and hyaluronic acid in 80 adults aged 21-50 with self-perceived thinning hair. Participants took the supplement or a placebo daily for three months. Researchers measured hair shedding and thickness using…

This study tested whether the diabetes drug metformin can treat moderate to severe facial acne as well as the antibiotic doxycycline. Sixty-eight people aged 12 to 40 took either metformin twice daily or doxycycline once daily for 12 weeks. Researchers counted pimples and used a …

This study tested whether adding ear acupressure to a standard acne gel (adapalene) helps clear pimples better than the gel alone. Researchers enrolled 64 people with mild to moderate acne and compared the combination to the gel-only group. The goal was to see if the combo reduce…

This study looked at whether covering the incubator with a white cover and giving baby massage during phototherapy can lower bilirubin levels and shorten treatment time in newborns with jaundice. Researchers studied 60 full-term babies receiving phototherapy. The goal was to see …

Pfizer completed a Phase 1 study testing a new topical drug called PF-07905428 for acne. The study included 52 healthy volunteers and people with moderate to severe acne, who applied the drug daily for 14 or 28 days. The main goal was to check safety and side effects, not to see …

This study tested a facial moisturizer in 47 people with mild to moderate acne over 4 weeks. Researchers checked skin dryness, redness, and overall appearance, and participants reported how their skin felt. The goal was to see if the moisturizer is gentle and helpful for acne-pro…

This study looked at whether taking probiotics can reduce a protein in the blood linked to acne inflammation. Researchers measured this protein in 50 adults with mild to moderate acne before and after probiotic treatment. The goal was to see if probiotics could help ease acne sym…

This Phase 2 trial tested a new acne gel called IDP-126 against a standard gel (Epiduo Forte) and a placebo gel in 686 people aged 12 and older with moderate to severe acne. Participants applied the gel once daily for 12 weeks. Researchers measured changes in acne lesion counts a…

This trial tested whether a laser procedure (Nd:YAG vitreolysis) can safely reduce symptoms from bothersome eye floaters, specifically a type called Weiss ring. Seventy adults with floaters for at least one month were randomly assigned to get the laser treatment either right away…

This pilot study tested whether cooling the skin with a device (the Zeltiq System) could safely reduce sebum production in 11 young men with acne. The treatment was applied to the upper back, and sebum levels were measured before and after. The goal was to see if a 30% reduction …

This study looks at how isotretinoin, a vitamin A-based acne medication, affects eye structures and tear production in people with severe cystic acne. Participants receive standard treatment and undergo eye exams, including dry eye tests and advanced imaging, before and during th…

This study tested whether AI-generated educational material on acne could teach medical students as well as standard human-written material. 190 first- and second-year medical students were split into three groups: one read AI-generated content, one read content from the Turkish …

This early study tested if gentle wounding (using a laser or mild scraping) can trigger new hair growth in people with a type of scarring hair loss called CCCA. Researchers mapped bald spots on the scalp, applied different wounding methods with or without FDA-approved creams, and…

This study looked at 20 adults with severe alopecia areata (hair loss) to see how the drug baricitinib changes certain immune markers in the blood. Researchers measured levels of two proteins, interleukin-15 and interferon gamma, before and after six months of treatment. The goal…

This study analyzed data from a database to understand how adults with severe alopecia areata and their doctors experienced treatment with ritlecitinib compared to older treatments. Researchers looked at patient characteristics, treatment history, and doctor satisfaction. The goa…

This study looked at 39 people with immune-related hair loss affecting at least half their scalp. Researchers collected blood, skin samples, and swabs to study genes, immune signals, and skin microbes. The goal was to better understand what causes alopecia, not to test a treatmen…

This study aimed to find the best way to diagnose excess hair growth (hirsutism) and hair loss in women with PCOS. Researchers studied 1330 women to determine the most accurate scoring method. The goal is to improve diagnosis and understanding of these common symptoms.

This completed trial tested two types of dental adhesives (acetone-based vs. isopropanol-based) for filling non-carious cervical lesions—tooth wear not caused by decay. Twenty-eight adults received fillings and were followed for 18 months to see which adhesive held up better. The…

This study examined whether a specific change in the TLR7 gene is more common in people with alopecia areata, an autoimmune condition that causes hair loss. Researchers compared 120 participants (patients and healthy volunteers) to see if the gene variant is linked to the disease…

This study looked at whether a specific gene (NR3C1) that helps control inflammation is linked to alopecia areata, an autoimmune condition that causes hair loss. Researchers compared 120 people with and without the condition to see if gene variations affect disease risk or severi…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study examined how the COVID-19 pandemic impacted skin allergy visits among healthcare workers. Researchers analyzed records from 341 healthcare workers who visited skin clinics before and after the pandemic. The goal was to understand if increased use of masks, gloves, and …