Acute myocardial infarction

This trial tests whether a cardiac rehabilitation program based on a socio-ecological model can improve recovery in adults who have had a first heart attack and undergone a stent procedure. The program goes beyond standard care by providing guidance on exercise, diet, medication,…

This phase 2 trial tests whether a single injection of selatogrel can rapidly prevent platelets from clumping together in adults having a heart attack. Participants receive either an 8 mg or 16 mg dose in the thigh, and researchers measure how quickly platelet activity drops. The…

This trial investigates whether gentle electrical stimulation of the ear (specifically the vagus nerve area) during emergency heart attack treatment can reduce heart muscle damage and improve recovery. Researchers are enrolling 110 adults having their first major heart attack who…

This study tests whether an interactive avatar-based game on a tablet can help people who have had a heart attack learn how to manage their health after leaving the hospital. Participants are randomly assigned to either standard face-to-face discharge education or the tablet game…

This trial compares two ways to insert a catheter into the heart during a heart attack: through the wrist (conventional) or through the hand (distal). The goal is to see which method is faster and causes fewer complications, such as blocking the wrist artery. About 550 heart atta…

This completed trial tested whether giving epinephrine and verapamil directly into the heart arteries could help restore blood flow in heart attack patients whose vessels remain blocked despite standard treatment. 104 adults with ST-elevation heart attacks were enrolled. The stud…

This study tested whether giving a low dose of the clot-busting drug tPA directly into the heart arteries, during standard angioplasty, improves blood flow and reduces complications in people having a major heart attack. 210 patients were enrolled. The goal was to see if this app…

This study tested whether a drug called dexrazoxane, given through a vein, can reduce permanent heart muscle damage in people having a severe heart attack (STEMI). Fifty adults received either the drug or a placebo during their standard stent procedure. The goal was to see if the…

This study tested a new way to give extra oxygen to the heart after a heart attack. Twenty patients received a special oxygen treatment for one hour through a thin tube placed in the heart artery. The main goal was to see if the procedure was safe and could be done without proble…

This study tested whether evolocumab (Repatha), a drug that lowers LDL cholesterol, can reduce inflammation and improve heart function in people who recently had a mild heart attack (NSTEMI). Sixty participants received either evolocumab or a placebo within 24 hours of admission.…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a new medicine called CDR132L in 294 people who had a recent heart attack and had weak heart pumping (ejection fraction 45% or less). Participants received one of two doses of CDR132L or a placebo, added to standard care, for 6 months. The goal was to see if the…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study tested whether a short course of doxycycline, a common antibiotic, can prevent heart damage after a heart attack. 174 adults who had a severe heart attack received either doxycycline or a placebo twice daily for one week. Researchers then used MRI scans to check heart …

This study looked at two ways to treat heart attack patients who have multiple blocked arteries. One group had all blockages fixed in a single procedure, while the other group had the main blockage fixed first and the others in a separate procedure later. The goal was to see if t…

This study looked at 128 heart attack patients who had a procedure to open blocked arteries. Some patients received an extra blood thinner called cangrelor on top of standard ticagrelor. The goal was to see if the combination improved blood flow to the heart and reduced leftover …

This study tested whether giving a single, strong dose of steroids to people right after a major heart attack (STEMI) could reduce the amount of heart muscle that gets permanently damaged. The steroid was given before the standard emergency procedure to open the blocked artery. T…

This study looked at whether using only ticagrelor (a blood thinner) after heart attack stenting is safe, instead of the usual two-drug combination. It included 200 adults who had a stent placed during a heart attack. The main goal was to check for serious heart problems or stent…

This study tested a new treatment for people who had a severe heart attack and still have weak heart pumping. Doctors took the patients' own blood stem cells, grew more of them in a special machine, and injected them into the heart. The goal was to see if this could improve heart…

This study tested a single intravenous infusion of stem cells (PROCHYMAL) in 220 adults who had their first heart attack within the prior week. The goal was to see if the treatment could safely improve heart function, as measured by MRI scans at 3 months. Participants were random…

This study tested whether giving a drug called atropine (which increases heart rate) during a heart artery-opening procedure can prevent dangerous heart rhythm problems in people having a specific type of heart attack. The study involved 158 participants and was completed. The go…

This study looked at whether a Mediterranean diet program could improve heart health in people who had a heart attack. 21 patients in cardiac rehab either got extra diet support or standard care for 12 weeks. Researchers checked blood pressure, cholesterol, blood sugar, and risk …

This study tested whether injecting a patient's own bone marrow stem cells into the heart's arteries could improve heart function after a heart attack. 90 adults with reduced heart pumping ability were randomly assigned to receive either stem cells plus standard care or standard …

This study tested whether giving N-Acetylcysteine (NAC), a drug often used for coughs, directly into the heart arteries during emergency angioplasty can reduce damage caused by restoring blood flow. Researchers measured markers of stress, inflammation, and cell death in 70 heart …

This study tested two types of exercise training—high-intensity interval training (HIIT) and moderate continuous training (MICT)—against standard physical activity advice in 188 people who had a heart attack. The goal was to see which approach best improves fitness and reduces he…

This completed study looked at whether evolocumab, a cholesterol-lowering injection, can reduce major heart problems in people who had a heart attack and have several blocked arteries. Researchers analyzed data from 1862 patients to see if the drug lowers the risk of cardiac deat…

This study tested whether a smartphone app and regular phone calls could help people with heart or lung disease complete rehabilitation at home instead of going to a clinic. The program included exercise tracking, education, and counseling over 12 weeks. Researchers wanted to see…

This study tested a new medicine called FDY-5301 in 120 people having a severe heart attack (STEMI). Participants received either the drug or a placebo during a procedure to open blocked arteries. The main goal was to see if the drug could reduce dangerous heart rhythm problems a…

This study tested a new medicine called SGC001 in 38 people having a heart attack procedure. The goal was to see if it is safe and might reduce heart muscle damage and inflammation. Participants received either the drug or a placebo by IV once. The drug is not yet approved anywhe…

This study looked at whether a drug called trimetazidine can reduce scarring in the heart muscle after a heart attack. 194 people who had a specific type of heart attack took the drug for six months. Researchers used MRI scans to measure the amount of scarring.

This study tested whether the diabetes drug dapagliflozin can reduce inflammation and improve outcomes in people with type 2 diabetes who recently had a heart attack. Researchers gave 143 patients either dapagliflozin or standard care for 6 months. They measured heart complicatio…

This study looked at whether a specific heart procedure, done a few minutes after blood flow returns naturally, can limit heart muscle damage in people having a major heart attack. 72 adults with a first heart attack and partially open arteries took part. Researchers measured hea…

This study tested whether a medicine called henagliflozin can reduce the size of heart damage and improve heart function in people who had a severe heart attack. 248 adults took the drug or a placebo for 6 months after a procedure to open blocked arteries. Researchers measured he…

This study tested whether adding evolocumab, a drug that lowers bad cholesterol, to standard care helps people who recently had a heart attack. The goal was to see if it reduces cholesterol and inflammation in the heart and blood vessels. 100 adults aged 25 to 90 who had a specif…

This study tested whether adding a special pressure wire measurement (FFR) to standard angiography helps doctors decide the best treatment for people with multiple blocked heart arteries. Over 900 patients were randomly assigned to get either angiography alone or angiography plus…

This completed study looked at whether the diabetes drug empagliflozin (Jardiance) can help repair heart damage in diabetic patients who had a major heart attack. 200 participants took either 10 mg or 25 mg of the drug daily for 6 months. Researchers measured changes in heart siz…

This study tested a single injection of FDY 5301 in over 2,300 people who had a severe type of heart attack (anterior STEMI) and were getting emergency artery-opening treatment. The goal was to see if the drug could lower the chance of dying or developing heart failure within a f…

This study compared two drug-coated stents (Synergy and Xience) in 240 people who had a heart attack. The goal was to see which stent leads to better artery healing over three years, focusing on plaque buildup inside the stent. Both stents release a drug to prevent scarring, but …

This study tested whether a single injection of cyclosporine, given right before opening a blocked artery, could improve outcomes for people having a major heart attack. About 970 patients received either cyclosporine or a placebo. Researchers tracked deaths, hospitalizations for…

This study tested a stent retriever device, already used for strokes, to remove clots during heart attacks. The goal was to reduce damage to small heart blood vessels caused by clot fragments. 81 patients with severe heart attacks were enrolled to see if the device works better t…

This study tested whether a supplement combining curcumin (from turmeric) and piperine (from black pepper) can reduce inflammation and oxidative stress in 50 adults who had a heart attack and underwent a procedure to open blocked arteries. Participants took the supplement or a pl…

This study tests whether a software tool called AutocathFFR can accurately measure the severity of coronary artery blockages from standard 2D angiogram images, compared to the gold-standard invasive FFR measurement. The software uses machine learning to analyze images taken durin…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study tests whether artificial intelligence can read a standard ECG to predict how much heart muscle is damaged after a heart attack. Researchers will compare AI-ECG results with MRI images, the current gold standard, in 461 patients who had a heart attack and underwent a pr…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study tests an artificial intelligence platform called Willem that analyzes electrocardiograms (ECGs) to detect heart attacks. Researchers will compare how fast and accurately the AI spots heart attack patterns versus human doctors. The study involves 500 adults who have had…

This study tested a new one-hour diagnostic algorithm using a protein called FABP to quickly confirm or rule out a type of heart attack called NSTEMI. It involved 20 male patients who arrived at the hospital within 4 hours of chest pain. The goal was to see if measuring FABP leve…

This study looked at whether a high-sensitivity blood test for troponin I can accurately determine the stage of a heart attack. Researchers analyzed data from 312 patients across multiple hospitals. The goal is to provide a faster, simpler way to classify heart attack severity wi…

This study tested whether offering genetic screening to younger heart attack patients (under 60) can uncover hidden cases of Familial Hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Researchers recruited 140 patients admitted with a heart attack a…

This study tested whether a simple bedside heart ultrasound measurement, called the S' wave, can help emergency doctors quickly identify acute coronary syndrome (heart attack or unstable angina) in patients with chest pain. Researchers enrolled 66 adults who came to the ER with c…

This study tested whether starting with a special CT scan (CT perfusion) could safely reduce the need for invasive heart catheterization in 180 patients with a mild type of heart attack called NSTEMI. Patients in the CT group first got a CT scan, and only those with concerning re…

This study tested a new blood test called SpinChip hs-cTnI that measures troponin, a protein released during a heart attack. Researchers wanted to see if this test could accurately diagnose heart attacks in 1,551 adults arriving at the emergency room with chest pain or other symp…

This study measured troponin I levels in 1355 healthy adults to determine normal ranges for a new rapid test called SpinChip hs-cTnI. Troponin is a protein released during a heart attack, and having accurate normal values helps doctors diagnose heart attacks more reliably. The te…

This study tested a portable, unshielded magnetocardiography (MCG) device in the emergency department to see if it could reliably detect heart attacks. 124 patients with symptoms of acute coronary syndrome participated. The main goal was to see if the device could collect usable …

This pilot study tested whether a common blood test for troponin, a heart damage marker, can tell if a heart attack involves bleeding in the heart muscle. Researchers measured troponin levels in 227 patients after they had a heart attack and compared those with and without bleedi…

This study tested a new blood test that measures a protein on platelets called FcγRIIa. Researchers wanted to see if higher levels of this protein could predict future heart attacks, strokes, or death in people who had already had a heart attack. About 764 participants were enrol…

This study tested a 20-minute nurse-led discussion and leaflet for people who had a specific type of heart attack (STEMI). Forty patients from two hospitals were randomly assigned to receive the full intervention or a shorter version. Researchers measured how many patients agreed…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This study analyzes data from over 3 million patients in China's Chest Pain Center registry to understand how people with acute chest pain are diagnosed and treated in real hospitals. It focuses on conditions like heart attacks, unstable angina, aortic dissection, and pulmonary e…

This study analyzes data from over 377,000 people who had a heart attack and were prescribed blood thinners (clopidogrel, ticagrelor, or prasugrel) in Germany and the United States between 2011 and 2024. Researchers aim to describe how often each drug is used and how much it cost…

This pilot study looks at how common iron deficiency is in people who have recently had a heart attack. Researchers will test iron levels in up to 70 patients and review their medical records. The goal is to gather early data to plan a larger study on whether treating low iron co…

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This study looked at 150 patients who had a heart attack 12 to 36 hours earlier. Researchers wanted to see if opening the blocked artery right away was better than waiting a few days. They used MRI scans to measure heart muscle damage and function.

This study tested whether a special heart ultrasound (speckle tracking echocardiography) can predict which patients need an implantable defibrillator (ICD) after a large heart attack. Researchers followed 200 patients for 90 days to see whose heart function stayed low enough to q…

This study looked at how well two types of stents (small mesh tubes) placed in heart arteries after a heart attack become covered by the body's own cells. 22 people who had a heart attack were randomly assigned to get either a SYNERGY stent or a bioresorbable scaffold. Doctors us…

This study looked at whether using a heart ultrasound probe (TEE) during low-risk coronary artery bypass surgery should be done routinely or only when needed. Researchers enrolled 40 patients and checked if it was possible to randomly assign them to one of two groups. The goal is…

This study looked at 30 people who had a heart attack and were treated with a procedure to open blocked arteries. Researchers used a special heart scan soon after treatment to see how much heart muscle was saved. They then checked if that scan could predict how well the heart wou…

This completed study looked at 530 heart attack survivors from 25 Spanish hospitals to see if women and men differ in how well they follow prevention advice, like taking medications, eating healthy, exercising, and joining rehab programs. Researchers matched women and men by age …

This study looked at the gut bacteria of 200 heart attack patients, comparing those with high blood sugar to those with normal levels. Researchers collected stool samples before treatment and again at 6 and 12 months to see if changes in gut bacteria relate to survival. The goal …

This study looked at 100 people who had a heart attack to see if certain inflammation markers in the blood could predict who might die or develop heart failure within 6 months. Researchers measured these markers at several time points after the attack. The goal was to better unde…

This study looked at 264 patients who had a heart attack complicated by cardiogenic shock. Researchers examined whether the ratio of red blood cell distribution width to albumin (RAR) in the blood could predict major heart problems like death, another heart attack, or stroke duri…

This study looked at whether a telehealth program could help paramedics treat people having a severe heart attack (STEMI) more quickly. Researchers measured times from first contact to treatment in 11 patients in Wilkes County. The goal was to see if remote support from doctors c…

This study tested an AI system that reads medical records of 308 heart disease patients and pulls out key information like test results and diagnosis types. The AI's accuracy was compared to that of seven doctors. The goal was to see if AI can help make clinical data collection f…

This completed study tracked 832 heart attack patients in China who developed new-onset atrial fibrillation during their hospital stay. Researchers used continuous heart monitoring to see how the amount of AFib affected risks like death, another heart attack, or heart failure. Th…

This study looked at 100 people who recently had a major heart attack to better understand blood clots that can form in the heart's main pumping chamber. Using special PET/MR scans, researchers tracked clot activity in the heart and brain over several months. The goal was to lear…

This completed study looked at 250 adults who had a severe type of heart attack (STEMI) treated with a stent. Researchers used portable heart monitors to check how often dangerous heart rhythms occurred in people whose heart attack involved bleeding. The goal was to better unders…

This completed study looked at over 6,000 heart attack patients to see how different antiplatelet medications affect the risk of bleeding inside the heart. Researchers compared outcomes like heart-related events, bleeding complications, and death within 30 days. The goal is to he…

This study tested whether a computer-based decision support system (DSS) helps doctors start or intensify cholesterol-lowering treatments earlier in patients who have had a heart attack. Over 1,100 patients from multiple hospitals took part. The DSS provided risk estimates but di…

This study looked at how long people who had a heart attack should take two blood-thinning medicines (aspirin plus a second drug). About 5,000 patients were randomly assigned to shorter or longer treatment. The goal was to find the best balance between preventing another heart at…

This study looked at whether certain genes are linked to a complication called 'no-reflow' that can happen during emergency artery-opening procedures for heart attacks. Researchers analyzed blood samples from 80 heart attack patients to find genetic markers. The goal is to better…

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This study looked at 1,000 people who had a severe type of heart attack (STEMI). Researchers checked two simple nutrition scores (CONUT and PNI) based on routine blood tests taken when patients arrived at the hospital. The goal was to see if these scores could predict who was mor…

This study looked at 250 people who had a severe type of heart attack involving bleeding into the heart muscle. Researchers tested whether a measurement called the wall strain index ratio, taken from a heart MRI, could identify areas of the heart at risk of tearing (rupture). The…

Researchers have created a prediction score to estimate the chance of a hemorrhagic (bleeding) heart attack in patients before they undergo emergency artery-opening treatment. The study involved 252 adults having their first heart attack and treated with primary PCI. The goal is …

This study looked at how different blood-thinning drugs are used in Italian hospitals for patients having a heart attack. Researchers collected information from over 2,800 patients to see which drug combinations and timing doctors actually use. The goal was to describe current pr…

This study combined data from over 1,700 patients who had a heart attack or unstable angina and underwent a special imaging test (OCT) of their heart arteries. Researchers aimed to find factors that predict plaque erosion, a common cause of heart attacks. The goal is to better un…

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This study looked at whether a technique called postconditioning, done during angioplasty to reopen blocked heart arteries, can reduce damage to the heart muscle. 44 adults having their first heart attack took part. The researchers used MRI scans to measure the area of blocked sm…

This completed study of 88 heart attack patients looked at why some develop kidney injury after receiving contrast dye during a procedure to open blocked arteries. Researchers analyzed medical records to find which factors—like age, lab results, or procedure details—were linked t…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study looked at 1,586 heart attack patients who had multiple blocked arteries. After opening the main blockage, doctors compared doing a second procedure to fix the other blockages either early (within a few days) or later (weeks after). The goal was to see which timing bett…

This study tested whether briefly restricting blood flow to an arm (remote ischemic conditioning) before opening a blocked heart artery could reduce heart damage. Only 2 patients took part, so the results are not meaningful. The study looked at heart function, kidney problems, an…

This study looked at 674 people who had a severe type of heart attack (STEMI) and were treated with a procedure to open blocked arteries. Researchers checked if a simple blood test called the triglyceride glucose (TyG) index could predict how much heart muscle was damaged and the…

This study looked at 407 people with a type of heart attack called NSTEMI to see if getting a heart procedure (coronary angiography) within 24 hours leads to better outcomes. Researchers checked how well following this timing guideline predicted death, another heart attack, strok…

This completed study looked at how levels of C-reactive protein (CRP), a marker of inflammation, change in 35 patients having emergency angioplasty for a heart attack. Researchers took blood samples before the procedure and at several time points up to 30 days after. The goal was…

This completed study looked at 1,000 heart attack patients to understand why some have no standard risk factors like smoking, high blood pressure, or diabetes. Researchers compared these 'SMuRF-less' patients to those with risk factors, examining their medical history, lab tests,…

This completed study looked at 12,500 cancer patients who had a type of heart attack called NSTEMI. Researchers compared those who got invasive procedures like angiography versus those treated only with medications. The goal was to see which approach led to fewer deaths in the ho…

This completed study followed 281 people who had a severe type of heart attack called STEMI. Researchers collected blood samples, ECGs, MRIs, and quality-of-life questionnaires to find new biological and imaging markers that could help predict outcomes like heart failure. The goa…

This study looked at 21 people who had a heart attack to see if markers of inflammation in the blood are linked to the amount of heart damage seen on MRI scans. Researchers measured inflammation levels at several time points and compared them to MRI images taken a week later. The…

This completed study looked at medical records from over 24,000 people across the United States who had a heart attack. The goal was to find out how often a specific complication called hemorrhagic myocardial infarction (bleeding inside the heart muscle) occurs. Researchers also …