OVERWEIGHT

This study looked at what works best for keeping weight off after stopping popular GLP-1 drugs like Wegovy or Zepbound. About 226 adults who had lost at least 15% of their body weight on these medications were followed for 12 weeks after stopping. The goal was to see which step-d…

This early-stage study tested whether adding a new drug (LY3841136) to an existing weight-loss medication (tirzepatide) is safe and tolerable in overweight and obese adults. A total of 96 healthy volunteers with a BMI between 27 and 45 took part. The study lasted up to 42 weeks a…

This study tested two weight loss programs in 223 adults with overweight or obesity. One group followed a fixed daily calorie limit, while the other varied their calorie intake day-to-day. The goal was to see which approach leads to more weight loss.

This study tested a new daily injection called LY3549492 to help adults with obesity or overweight lose weight. About 288 participants received either the drug or a placebo for roughly one year. The main goal was to see how much weight people lost and how safe the treatment was.

This study tested a new medication called aleniglipron (GSBR-1290) to help people with obesity or overweight lose weight. 85 adults took different doses of the drug or a placebo for 44 weeks, along with diet and exercise. The main goals were to check safety and side effects, and …

This study tested an investigational injection called GZR18 in 340 Chinese adults with obesity or overweight. Participants received either the drug or a placebo, along with diet and exercise advice. The main goal was to see how much weight they lost after 30 weeks. The study is c…

This study tested a new weekly injection called CagriSema (a mix of two medicines) to help people with overweight or obesity and type 2 diabetes lose weight. About 1,200 adults took part, receiving either CagriSema or a placebo for around 1.5 years. The main goals were to see how…

This study tested a weekly injection of semaglutide (2.4 mg) in 201 teenagers ages 12 to 17 with overweight or obesity. Participants received either the drug or a placebo for about 15 months, along with lifestyle counseling. The main goal was to see how much their body mass index…

This study looked at whether omega-3 fatty acids can improve cholesterol levels and reduce inflammation in overweight or obese adults with high triglycerides. 40 participants in Chile took omega-3 supplements or a placebo in a crossover design. The goal was to see if a simple die…

This early-stage study tested a single dose of the investigational drug eloralintide in 30 Chinese adults who are overweight or have obesity. The main goal was to check for side effects and see how the drug moves through the body. Participants received either the drug or a placeb…

This study tested a weight management program designed specifically for veterans with PTSD who are overweight or obese. The program added extra support to standard PTSD care to help overcome barriers like stress and low motivation. 174 veterans took part, and researchers measured…

This study tested if standing on a vibrating platform (whole-body vibration) could help overweight and obese university students lose weight and improve body composition. Thirty-two students with a BMI of 25 or higher took part. Researchers measured changes in BMI, waist size, an…

This study tested whether the drug tirzepatide helps people with obesity or overweight maintain weight loss they already achieved. About 441 adults took either tirzepatide or a placebo once a week for up to 60 weeks. The goal was to see if the drug could help them keep off at lea…

This study tested a once-weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. About 375 adults took part, some receiving the drug and others a placebo, along with lifestyle advice. The main goal was to see how much weight they lost over …

This study looked at whether a three-month supervised exercise program can help men with type 2 diabetes, prediabetes, or obesity improve their blood sugar, body composition, and fitness. Three hundred sedentary men aged 35-65 took part in regular training sessions at a fitness c…

This study looked at whether adding a whey protein supplement to a reduced-calorie diet helps overweight and obese adults lose more weight and improve their metabolism. A total of 110 people aged 25 to 35 with a BMI of 24 or higher took part. The results will help guide better di…

This study tested whether an 8-week circuit exercise program (combining aerobic and resistance moves) could improve inflammation markers in 22 overweight women aged 20-30. Participants exercised four times a week at moderate-to-high intensity. Results showed the program increased…

This study tested whether a probiotic called Weizmania Coagulans BC99 could improve gut bacteria and blood fat markers in overweight adults. 72 participants took either the probiotic or a placebo daily for 8 weeks. Researchers measured changes in gut bacteria and fat-related mark…

This study looked at whether sharing digital self-monitoring data (like weight, activity, and food logs) with a friend or family member helps adults with overweight or obesity lose more weight over 24 months. 322 adults used digital tools to track their progress daily. The goal w…

This study looked at over 285,000 people with overweight or obesity to see if the weekly injection semaglutide (used for weight loss and diabetes) lowers the risk of heart problems like heart attacks, strokes, and death. Researchers analyzed medical records from 2016 to 2024. The…

This study tested an experimental drug called CT-868 in 103 overweight or obese adults with type 2 diabetes. The goal was to see if the drug could lower blood sugar levels and help with weight loss over 26 weeks. Participants received either the drug or a placebo, and researchers…

This study tested a culturally-tailored program that combines nutrition, exercise, and stress management to help African American women improve their heart health. 175 women with risk factors like high blood pressure or prediabetes took part. The goal was to see if the program co…

This study tested two medications, tirzepatide and semaglutide, to see which works better for weight loss in adults with obesity or overweight who also have related health problems like high blood pressure. About 751 people took part, and the trial lasted around 74 weeks. The mai…

This study tested a daily oral semaglutide tablet (25 mg) in 307 adults with overweight or obesity to see how well it helps reduce body weight. Participants took the drug or a placebo for 64 weeks, followed by 7 weeks of follow-up. The main goals were percentage weight loss and t…

This study compared a once-daily pill called orforglipron to insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had increased heart or kidney risk. The main goal was to see if orforglipron could delay or prevent major heart problems …

This study looked at whether eating quinoa and buckwheat instead of rice or bulgur helps overweight adults lose weight and improve their gut health. 148 healthy adults aged 25-45 with a BMI between 25 and 35 took part. Researchers measured weight, blood sugar, cholesterol, and ch…

This study tested a daily tablet called semaglutide to help people with overweight or obesity lose weight. 667 adults took either the real tablet or a dummy pill for 68 weeks, along with diet and exercise advice. The main goals were to see how much weight they lost and how many l…

This study tested whether a daily tablet of semaglutide (50 mg) helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with receiving advice on diet and exercise. The main goals were to see how muc…

This study tested whether giving extra support to less advantaged teens helps them manage overweight as well as standard care helps more advantaged teens. About 1,689 high school students took part. The approach included group sessions, motivational talks, cooking classes, and fi…

This study tested whether an online family skills training program is practical and well-liked by Black adults trying to lose weight. 21 participants joined with a family member and attended online sessions. The goal was to see if this approach could support healthier eating and …

This study tested a program called Family Check-Up Heart, which adds heart-health coaching to home visits for new moms and their babies. About 117 mothers who had Medicaid and lived in Allegheny County took part. The goal was to see if the program helped moms keep a healthy weigh…

This study tested three different doses of a new drug, AMG 133, against a placebo in 592 adults with overweight or obesity. Some participants also had type 2 diabetes. The main goal was to see how much weight people lost after 52 weeks of treatment. The drug aims to help control …

This study tested a new medicine called survodutide in 307 Chinese adults with obesity or overweight who also had weight-related health problems. Participants received weekly injections of either survodutide or a placebo for about 19 months. The main goals were to see how much we…

This study looked at whether increasing everyday physical activities (like walking or household chores) along with regular aerobic exercise improves heart health more than exercise alone in overweight young women. Twenty-eight women with a BMI between 25 and 30 who sit for over 7…

This study tested a new weekly injection called CT-388 to help people with obesity or overweight lose weight. About 469 adults took part, receiving either a low, middle, or high dose of the drug or a placebo for 48 weeks. The main goal was to see how much weight they lost and if …

This study tested how orforglipron, an experimental pill, changes body fat compared to a placebo in 120 adults with obesity or overweight (but without diabetes). Participants were followed for about 8 months. The main goal was to see if the drug reduces visceral fat—the deep bell…

This study tested a once-daily pill called orforglipron to see if it helps people with obesity or overweight maintain weight loss they achieved in a previous study. 376 adults who completed the earlier weight-loss program took either the pill or a placebo. The goal was to measure…

This early-stage study tested a new drug called AMG 133 in 120 adults with overweight or obesity. Researchers gave multiple doses under the skin to see how the drug behaves in the body and whether it is safe. The goal was to gather information for future studies, not to treat or …

This study tested whether a natural plant product called EMIQ can help overweight and obese adults lose body fat safely. Sixty-five participants took either EMIQ or a placebo for a period of time, and researchers measured changes in body fat using special scans and skinfold measu…

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over six month…

This study tested a once-daily oral medication called orforglipron against a placebo in over 1,600 adults who are overweight or have obesity and also have type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants took t…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with excess body weight lose weight. 242 participants received either the drug or a placebo for about one year. The main goal was to see how much weight they lost and if at least 5% of body weight was red…

This study tested a program where community health workers visited families at home to help manage childhood obesity. 300 children aged 2-6 with overweight or obesity took part. The program aimed to improve diet, activity, and fitness to lower the child's BMI. Results will guide …

This study tested whether a fully-automated digital diabetes prevention program works as well as standard human coach-based programs. 368 adults with prediabetes and overweight took part. The goal was to see if the digital program could help people lose weight, increase physical …

This study tested whether an educational program for pregnant women who are overweight or obese could reduce the chance of their babies gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits during pregnancy. The goal…

This study tested a program to help pregnant women who are overweight or obese avoid gaining too much weight. It included 416 African American and Hispanic women in Philadelphia who were part of the WIC program. The program used text messages and guidance to support healthy eatin…

This early-stage study tested a new medicine (NNC0487-0111) for weight control in 36 Chinese adults with overweight or obesity. The main goal was to check safety and how the drug moves through the body. Participants received either the study drug or a placebo by injection, and we…

This study tested a new drug, NNC0487-0111, given as injections under the skin, to see if it is safe and how it works in the body. It involved 125 adults aged 18-55 who were overweight or obese. The main goal was to check for side effects and measure how the drug behaves in the b…

This study tested a once-weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if the drug helps with weight loss and reduces knee pain. Participants received either the drug or a placebo for ab…

This study tested a new drug (LY3841136) alone and with another weight-loss drug (tirzepatide) in 128 Japanese adults with obesity or overweight. The main goal was to check safety and side effects, and to see how the body processes the drugs. The study is complete, and results wi…

This early-stage study tested a new drug called eloralintide, given alone or together with tirzepatide, in 188 adults who are overweight or have obesity. The main goals were to check safety, side effects, and how the drugs move through the body. Participants received weekly injec…

This study looked at whether an 8-week Pilates exercise program could improve breathing in overweight and obese women. 54 women took part, doing core and abdominal exercises three times a week. Researchers measured lung function, breath-holding time, and quality of life before an…

This study tested whether drinking VitalPLANT or Helichrysum italicum tea for one week could improve signs of metabolic syndrome in 30 overweight adults. Participants had at least two components of metabolic syndrome and were not on medications for it. Researchers measured body w…

This study looked at whether omega-3 fatty acids can reduce inflammation and improve depression in people whose depression hasn't improved with standard antidepressants. 14 adults with treatment-resistant depression were randomly given either omega-3 or a placebo for 12 weeks. Re…

This study tested a new injectable medicine, NNC0662-0419, in 100 adults with overweight or obesity. The main goal was to check its safety and how the body processes it, as this was the first time it was given to humans. Participants received either the study drug or a placebo ov…

This study tested a combination medicine called CagriSema (cagrilintide and semaglutide) in 164 adults with overweight or obesity. Researchers measured changes in appetite, food intake, and brain activity using scans and questionnaires. The goal was to understand how the medicine…

This study checked whether the experimental drug survodutide (BI 456906) causes any heart rhythm changes in 110 adults with overweight or obesity. Participants received weekly injections of survodutide or a placebo for about 30 weeks, along with a single dose of moxifloxacin (a d…

This study looked at how giving mothers health information about their children might change the food choices they make. Over 1,100 mothers of children ages 3-7 took part. They used a virtual reality buffet to pick a meal for their child, both before and after watching a health p…

This study tested whether adding a nutrition program (BfedBwell) to an existing exercise program (BfitBwell) is practical and well-liked by cancer survivors who are overweight or obese. Twenty adults who finished cancer treatment within the last five years took part. The main goa…

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This study looked at 216 women ages 18-45 to see if body weight affects genital hygiene, toilet behaviors, body awareness, and bladder symptoms. Researchers compared normal-weight women to those who are overweight or obese. The goal is to raise awareness and improve quality of li…

This study looked at how eating beans changes the way the body uses fat, carbohydrates, and protein for energy. Researchers measured this in 36 overweight adults using a special room that tracks calorie burning. The goal was to understand the effects of bean-based foods, not to t…

This study looked at how an experimental drug for obesity (HRS-7535) interacts with four common medicines: acetaminophen (pain relief), digoxin (heart medication), rosuvastatin (cholesterol), and omeprazole (acid reflux). It involved 40 overweight or obese adults aged 18-50. The …

This study looked at a 2014 Danish law requiring all public schools to add 45 minutes of physical activity to each school day. Researchers measured activity levels and body mass index (BMI) in over 5,000 children before and after the policy took effect. The goal was to see if the…

This study follows up with people who were in the SELECT obesity medication trial to see how their health changes over the long term. No new treatment is given—participants just fill out health questionnaires every 6 months for up to 10 years. The goal is to track serious health …

This study looked at health data from over 550,000 Chinese adults to see how being overweight or obese affects heart disease. Researchers used national survey information to find out how common heart problems are in this group and how they change over time. No treatments were giv…

This study tested a 4-month nutrition education program for 811 ethnic minority children aged 5-16 in Tra Vinh, Vietnam. The program included monthly lessons, videos, and support activities. Researchers measured changes in weight, height, diet, and physical activity to see if the…

This study looked at why some people become obese by examining eating behaviors and food preferences, especially for high-fat foods. Researchers studied 669 healthy adults, including Pima Indians and Caucasians, to understand risk factors for obesity. Participants filled out ques…

This study looked at how type 2 diabetes works in children and young adults aged 12 to 25. Some participants took diabetes medicine with or without extra insulin to see if resting the pancreas could help it make more insulin. The study also compared them to healthy volunteers to …

This study looked at why overweight or obese pregnant women choose to take part in a 12-week program that includes nutrition advice and weekly exercise sessions. Researchers tracked 195 women to see which factors—like age, health history, or motivation—influenced their participat…

This study looked at how a new weight-loss drug called BI 456906 affects the way the body processes three common drugs: bupropion, caffeine, and midazolam. Thirty-four healthy adults with overweight or obesity took these drugs alone and then again while receiving weekly injection…

This early-stage study tested a single dose of a new drug called SAR441255 in 48 healthy adults who were lean to overweight. The main goal was to check if the drug is safe and how the body processes it. Researchers also looked at how it affects blood sugar levels. This study does…

This study looked at how community organizations can successfully run a healthy lifestyle program called Deaf Weight Wise for Deaf adults who use American Sign Language. Researchers worked with partners in Buffalo, Rochester, and Syracuse, New York, to see if they could deliver t…

This study looked at how a single session of walking or jogging changes appetite-related hormones and brain activity in 40 adults who were either normal weight or overweight/obese. Researchers measured hormones like oxyntomodulin and ghrelin in blood samples and asked about hunge…

This study looked at how a short, intense exercise test changes blood markers in 35 teenage girls—some at a healthy weight and some overweight or obese. Researchers measured things like blood sugar, cholesterol, inflammation, and muscle enzymes before, right after, and 30 minutes…

This study tested whether sending specific text messages at the right time helps young adults with overweight or obesity meet their daily goals for weighing themselves, being active, and limiting certain foods. Over 200 participants used a mobile weight loss program and received …

This study followed 200 children and young adults who are overweight or have high blood pressure. Researchers collected health information from their medical records to learn how weight affects the heart over time. The goal is to better understand these risks, not to test a new t…

This study aimed to understand why some people develop type 2 diabetes by looking at genetic and lifestyle factors. About 1,759 overweight adults aged 18-55 took part in tests measuring how their bodies handle sugar and store energy. The goal was to find genetic markers and early…

This study tested whether a medical body composition scale (mBCA 555) could detect early improvements in health—like changes in muscle or fat—in 41 overweight adults using L112 weight loss products, even before they lost noticeable weight. The goal was to find small successes tha…

This early-stage study looked at how safe a new drug called HU6 is and how the body processes it. Fifty-nine overweight adults took HU6 as tablets or capsules, either with or without food. The main goal was to measure drug levels in the blood, not to treat or cure a condition.

This study looked at how the drug GZR18 is processed and eliminated from the body in 6 overweight or obese Chinese men. Participants took a single dose with a radioactive label, and researchers measured the drug and its breakdown products in blood, urine, and stool over about 11 …

This study looked at health records from over 887,000 people with type 2 diabetes and overweight to compare two drugs—tirzepatide and semaglutide—for preventing heart attacks, strokes, or death. The goal was not to test a new treatment but to see if analyzing real-world data can …

This study looked at whether taking an anti-nausea medication (ondansetron) changes the amount of AMG 133 in the blood of people who are overweight or obese. 59 adults took AMG 133 alone or with the anti-nausea drug. The goal was to measure drug levels and check for side effects,…

This early-stage study looked at how a low-fat meal and taking the drug in the evening change the way KAI-7535 moves through the body. It involved 18 healthy adults who were overweight or obese. The goal was to gather information for future dosing instructions, not to treat or cu…

This early-stage study tested a single dose of a new medicine, NNC0662-0419, in 100 adults with overweight or obesity. Researchers wanted to see how the drug behaves in the body and whether it is safe in Japanese, Chinese, and non-Asian participants. The study lasted up to 2 mont…