Can a pill keep the weight off after zepbound or wegovy?
NCT ID NCT06584916
First seen Jan 07, 2026 · Last updated Jun 23, 2026 · Updated 20 times
Summary
This study tests whether a daily pill called orforglipron can help people with obesity or overweight maintain the weight they lost using injectable medications like tirzepatide (Zepbound) or semaglutide (Wegovy). About 376 participants who completed a prior weight-loss trial will take either orforglipron or a placebo for a period of time. The main goal is to see if the pill helps them keep the weight off.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alliance for Multispecialty Research, LLC
Norman, Oklahoma, 73069, United States
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Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, 48098, United States
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Biopharma Informatic, LLC
Houston, Texas, 77043, United States
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Cahaba Research
Birmingham, Alabama, 35242, United States
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Cahaba Research - Pelham
Pelham, Alabama, 35124, United States
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Encompass Clinical Research
Spring Valley, California, 91978, United States
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Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, 50265, United States
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L-MARC Research Center
Louisville, Kentucky, 40213, United States
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Lillestol Research
Fargo, North Dakota, 58104, United States
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New Horizon Research Center
Miami, Florida, 33165, United States
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North Texas Endocrine Center
Dallas, Texas, 75231, United States
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Palm Research Center Sunset
Las Vegas, Nevada, 89148, United States
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Palm Research Center Tenaya
Las Vegas, Nevada, 89128, United States
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PharmQuest Life Sciences, LLC
Greensboro, North Carolina, 27408, United States
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PlanIt Research, PLLC
Houston, Texas, 77079, United States
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Prime Health and Wellness/SKYCRNG
Fayette, Mississippi, 39069, United States
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Puerto Rico Medical Research
Ponce, 00717, Puerto Rico
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Rocky Mountain Clinical Research
Idaho Falls, Idaho, 83404, United States
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Rophe Adult and Pediatric Medicine/SKYCRNG
Union City, Georgia, 30291, United States
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Southern California Dermatology, Inc.
Santa Ana, California, 92701, United States
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Southern Endocrinology Associates
Mesquite, Texas, 75149, United States
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StudyMetrix Research
City of Saint Peters, Missouri, 63303, United States
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The University of Texas Health Science Center at Houston
Bellaire, Texas, 77401, United States
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Tribe Clinical Research, LLC
Greenville, South Carolina, 29607, United States
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University Clinical Investigators, Inc.
Tustin, California, 92780, United States
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Velocity Clinical Research, Dallas
Dallas, Texas, 75230, United States
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WR-Clinsearch, LLC
Chattanooga, Tennessee, 37421, United States
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Weill Cornell Medical College
New York, New York, 10021, United States
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Wellness clinical Research Vega Baja
Vega Baja, 00694, Puerto Rico
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
orforglipron (a daily pill)
What this could lead to
If successful, this could offer a convenient daily pill to help people keep off weight they lost with injectable medications like Zepbound or Wegovy.
What could go wrong
This is a maintenance study, not a new weight-loss treatment. It is still early, and results may not apply to everyone. Side effects of orforglipron are not yet fully known.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.