OVERWEIGHT

This study tests two new drugs, CagriSema and cagrilintide, to help children and adolescents with overweight or obesity lose weight. About 460 participants will receive either the study drugs, a standard drug (semaglutide), or a placebo for up to 4 years and 10 months. The goal i…

This study tests whether replacing some animal protein with plant protein can improve blood sugar control in people with type 2 diabetes who are overweight. About 146 adults will follow either a plant-based diet or a standard healthy diet for 24 weeks. The main goal is to see if …

This study tests a new weekly injection called eloralintide to see if it helps adults with obesity or overweight lose more weight when added to their current weekly weight-loss medication. About 900 participants will receive either eloralintide or a placebo for around 80 weeks. T…

This study tests whether eating protein and fiber bars three times a day as part of a low-calorie diet helps people with overweight or obesity lose weight and improve heart, joint, and metabolic health. About 144 adults aged 18-65 with a BMI between 27 and 40 will be assigned to …

This study is testing different ways to increase the dose of a medication called retatrutide to help people with obesity or overweight lose weight. About 600 participants who do not have diabetes will take the drug for around 113 weeks. The main goal is to see how much weight the…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will take the drugs or a placebo for 48 weeks. The main goal is to see how much weight they l…

This study tests whether a new medicine, UBT251, is safe and helps people with overweight or obesity lose weight. About 333 adults will receive either UBT251 or a placebo (dummy pill) by chance. The main goals are to check for side effects and measure weight change over time.

This early-stage study tests a new drug called LY4167586 in 84 adults who are overweight or have obesity but are otherwise healthy. The main goal is to check the drug's safety and how the body processes a single dose. Participants will be monitored for about 7 months, and the stu…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, thinking skills, and gut bacteria in women aged 20-65 who have prediabetes and are overweight. Participants will take the powder for a set period while researchers…

This study is testing whether a special chewing gum containing galactooligosaccharides (GOS) can help overweight adults lower their body mass index (BMI) and improve their metabolism. Researchers will also look at how the gum affects bacteria in the mouth and gut. The study invol…

This study tests a once-weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The goal is to see if the drug can improve breathing during sleep and help with weight loss. Participants will be fo…

This study tests whether meal replacements can help low-income adults who are overweight or have prediabetes or type 2 diabetes lose weight and lower blood sugar. Twenty participants will follow an intensive nutrition program for several weeks. Researchers will measure weight los…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who do not use a breathing machine. The goal is to see if the drug helps them lose weight and reduce breathing pauses during sleep …

This study tests several experimental treatments to help adults with obesity or overweight lose weight and keep it off. About 1,481 participants will try different medicines or a placebo. The goal is to find safe and effective options for long-term weight management.

This study tests a new once-weekly injection called NNC0487-0111 for people who are overweight or have obesity and type 2 diabetes. About 630 adults will receive either the active drug or a placebo for several weeks. The main goal is to see if the drug safely helps reduce body we…

This study looks at whether adding extra virgin olive oil to the diet can improve liver health in people who are overweight and have a fatty liver condition called MASLD. Researchers will measure changes in liver fat, blood sugar, cholesterol, and inflammation over time. The goal…

This study tests a new once-weekly injection, NNC0487-0111, in 300 adults who are overweight or have obesity and also have moderate-to-severe obstructive sleep apnea treated with a breathing machine. Participants are randomly assigned to receive either the study drug or a placebo…

This study tests a once-daily oral medication called orforglipron in 125 adolescents (ages 12-17) who have obesity or are overweight with related health issues. Participants take either the drug or a placebo for about 18 months. The main goal is to see how much body mass index (B…

This study tests a new medicine called MET097, given as a weekly shot, to help adults who are overweight or have obesity and type 2 diabetes lose weight. About 1,000 people will take part; two-thirds get the real medicine and one-third get a placebo. The study lasts about 21 mont…

This study aims to help overweight or obese taxi and ride-share drivers lose weight. About 1,785 drivers will receive a combination of counseling, text messages, phone support, and self-monitoring tools. The goal is to find the most effective and affordable way to help this hard-…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries and have their blood pressure, artery stiffness, and memory tested. The…

This study tests a new drug called brenipatide in healthy adults who are overweight or have obesity. Participants receive different doses as injections under the skin to see how much weight they lose and if the drug is safe. The study lasts about 42 weeks and involves 150 people.

This study tests whether a new medication, maridebart cafraglutide, can reduce the risk of heart attacks, strokes, and heart-related death in people who have both heart disease and are overweight or obese. About 12,800 adults aged 45 and older will receive either the drug or a pl…

This early-stage study tests an experimental injection called SHR-2906 in healthy volunteers and people with obesity. The main goal is to check safety and how the body processes the drug. Around 124 participants will receive either the drug or a placebo to gather initial data.

This study checks if two versions of the drug survodutide work the same way in the body. It involves 80 healthy adults who are overweight or have obesity. Participants will receive both formulations at different times to compare how the drug is absorbed and processed.

This study tests a new weekly injection called KAI-9531 to help people with obesity or overweight lose weight. It includes 1,800 adults who do not have diabetes but have weight-related health problems like high blood pressure or sleep apnea. Participants receive either the drug o…

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study compares two ways to help people with overweight or obesity lose weight: avoiding tempting situations (AVOID) or practicing self-control when faced with cravings (RESIST). About 500 adults will be followed for 12 months to see which approach works better for weight los…

This study tests two minimally invasive procedures that reduce stomach size to help with weight loss. It involves 184 adults aged 21–65 with obesity (BMI 30–50) who have not lost weight through diet or exercise alone. Participants will receive either the new EndoZip system or the…

This study tests a new weekly injection called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for 75 weeks. Researchers will measure changes in body weight, fat, waist size, and b…

This early-stage study tests a new drug called HRS-5817, given as an injection, to see if it is safe and how the body processes it. The study involves 92 healthy adults, some with obesity and some without. Researchers will monitor side effects and measure drug levels in the blood…

This study tests a new once-weekly injection called eloralintide for weight loss in adults with obesity or overweight who do not have type 2 diabetes. About 1,980 participants will receive either the drug or a placebo for up to 75 weeks, with some continuing for 2 more years. The…

This study tests the safety and effectiveness of tirzepatide in 344 Indian adults with type 2 diabetes or obesity. Participants receive the drug for 46 weeks. The goal is to see if it helps control blood sugar and reduce weight.

This study tests the safety and effectiveness of new medicines to help children and teens with obesity or overweight manage their weight long-term. It includes 125 participants aged 12 to 17 who have already tried lifestyle changes like diet and exercise without enough success. T…

This study tests whether adding a specially trained doula to standard care helps new mothers with pregnancy-related high blood pressure improve their blood pressure one year after giving birth. About 454 women who had preeclampsia or similar conditions will be randomly assigned t…

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study tests whether a diet plan based on your genetic makeup helps you lose more weight and body fat than standard dietary advice. About 88 overweight adults will receive either personalized genetic counseling or general diet tips. Researchers will measure changes in body we…

This study tests an experimental daily pill called KAI-7535 to see if it helps people with obesity or overweight lose more weight than a placebo. The trial includes 320 adults who also have at least one weight-related health problem like high blood pressure or sleep apnea. Partic…

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This study looks at whether adjusting meal timing can reduce health risks for night-shift nurses and nursing assistants who are overweight. Participants will either track their diet, follow a 10-hour daytime eating window, or add a low-glycemic snack during night shifts. The goal…

This early-stage study tests a new nasal spray form of semaglutide (WL1006) in 60 overweight or obese adults. The main goal is to check safety and how the drug moves through the body, not weight loss itself. Participants receive a single dose and are monitored closely.

This study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or have obesity and also suffer from knee osteoarthritis. The goal is to see if the drug helps with weight loss and reduces knee pain compared to a placebo. Participants are randomly ass…

This study tests a once-weekly injection called retatrutide to see if it can relieve chronic low back pain and help with weight loss in people who have obesity or overweight. About 586 participants will receive either the drug or a placebo for up to 80 weeks. The main goals are t…

This study tests whether a once-weekly injection of semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive either semaglutide or a placebo, and researchers will track changes in body weight, body fa…

This study is testing an experimental medicine called cagrilintide to see if it can reduce how much people eat and their appetite. About 120 adults with overweight or obesity will receive either the drug or a placebo for around 30 weeks. The main goal is to measure changes in tot…

This early-stage study tests a new medicine called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in different parts of the study …

This early-stage study tests whether a new medicine, NNC6989-0001, is safe for healthy people who are overweight or have obesity. About 96 participants will receive either the drug or a placebo by chance. The main goal is to check for side effects and how the drug moves through t…

This study looks at whether personalized nutrition and exercise plans can help reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (androgen deprivation therapy). About 50 participants will receive tailored advice and be monitored f…

This early-stage study looks at whether combining two experimental weight-loss drugs (cagrilintide and NNC0480-0389) causes less nausea, vomiting, and diarrhea than taking cagrilintide alone. About 100 women with overweight or obesity will receive both combinations at different t…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This study looks at how your internal clock (chronotype) affects blood sugar control in overweight young adults aged 18-23. Researchers will compare what happens when meals and glucose tests are timed to match or mismatch your natural sleep-wake cycle. The goal is to understand i…

This study looks at how a park-based afterschool program called Fit2Play affects children's physical fitness and mental health. Researchers will analyze data from about 5,000 kids to see changes in weight, blood pressure, fitness tests, and feelings of anxiety or depression. The …

This study looks at how a low-carbohydrate diet and a supplement called nicotinamide riboside (NR) change the way the body uses fat for energy. Researchers will measure things like how many calories participants burn while sleeping and how much fat they burn. The study involves 1…

This study looks at what happens to appetite and food choices when physically active men aged 40 to 55 suddenly stop exercising for two weeks. Participants are randomly assigned to either keep their normal routine or drastically cut back activity (under 1,500 steps a day). Resear…

This study looks at whether starting with a low-carbohydrate diet and then switching to a low-fat diet leads to more body fat loss than the opposite order. Over 8 weeks, 42 overweight adults will eat only delivered meals and track their weight, activity, and blood sugar at home. …

This study looks at whether the artificial sweetener sucralose changes how the body absorbs and processes certain medicines. Researchers will give healthy overweight Black and Hispanic women a daily sucralose capsule or a placebo for four weeks, then measure drug levels, hormones…

This early-stage study looks at how a new weight-loss medication, maridebart cafraglutide, changes the way oral contraceptives are processed in the body. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth co…

This early-stage study tests an experimental oral drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check the drug's safety and how it interacts with two common statins (pitavastatin and rosuvastatin). Participants will receive multiple doses o…

This study looks at how being overweight and having type 1 diabetes affects heart and muscle fitness. Researchers will test 60 adults to see if insulin resistance lowers exercise capacity, and whether a high-intensity interval training program can improve it. The goal is to bette…

This study looks at how eating different types of food (like high-carb vs. high-protein) affects what you want to eat later. Researchers want to see if this 'food memory' is different for people with normal weight, overweight, or obesity. 45 adults aged 18-45 will take part.

This study looks at how a new drug (NNC0662-0419) affects birth control pills and stomach emptying in 45 overweight women who cannot become pregnant. Participants will receive the study drug, a birth control pill, and a mild painkiller to measure drug levels in the blood. The goa…

This study follows 1,000 adults aged 50 and older who take part in a park-based fitness program in Miami-Dade County. Researchers will measure changes in weight, blood pressure, arm and leg strength, and mobility over time. The goal is to see if community exercise programs can im…

This study looks at whether eating honey-flavored yogurt every day for 4 weeks can lower low-grade inflammation and improve gut health in overweight women aged 45 to 65. Researchers will measure markers of inflammation and gut bacteria changes. The goal is to understand how diet …

This early-stage study tests a medicine called PF-08653944 in 20 adults who are overweight or have obesity. The goal is to see how it changes the speed at which the stomach empties food after a meal. Researchers will also check for side effects. The results will help plan future …