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New weekly shot could help sleep apnea and weight loss

NCT ID NCT07571109

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 10 times

Summary

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who use a breathing device. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Participants are randomly assigned to receive the drug or a placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NNC0487-0111 (a weekly injection for weight loss and sleep apnea)
What this could lead to
If it works, this could offer a new weekly injection that helps people with obesity and sleep apnea lose weight and breathe better during sleep.
What could go wrong
This is an early Phase 3 trial with 300 participants, so results may not apply to everyone. The drug may cause side effects or not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Male or female (sex at birth) * Age 18 years or above at the time of signing informed consent * Previously diagnosed moderate-to-severe OSA with an AHI ≥ 15, as diagnosed with polysomnography (PSG), home sleep apnoea test (HSAT), or other method that meets local guidelines prior to screening Key Exclusion Criteria: * Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol/mol) as measured by the central laboratory at screening * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records * Any planned or previous surgery within 90 days prior to screening for sleep apnoea, including septoplasty, turbinoplasty, or other ear, nose, and throat surgeries, including tonsillectomy and adenoidectomy * Significant craniofacial abnormalities that may affect breathing at baseline, for example Treacher Collins syndrome and Pierre Robin Sequence * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonist (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder obstructive sleep apnea syndrome Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Obstructive sleep apnoea Overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    89 sites in 10 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu

    RECRUITING

    Wroclaw, Dolnoslaskie Voivodeship, 50-981, Poland

  • 5 Wojskowy Szpital Kliniczny z Polikliniką-Samodzielny Publiczny Zakład Opieki Zdrowotnej w Krakowie

    RECRUITING

    Krakow, 30-901, Poland

  • Adana Şehir Eğitim ve Araştırma Hastanesi-Dahiliye

    RECRUITING

    Yuregir/Adana, 01060, Turkey (Türkiye)

  • Advanced Neurology Epilepsy and Sleep Center ANESC

    RECRUITING

    El Paso, Texas, 79912, United States

  • All India Institute of Medical Sciences (AIIMS), Bhubaneswar

    NOT_YET_RECRUITING

    Bhubaneswar, Odisha, 751019, India

  • All India Institute of Medical Sciences_Delhi

    RECRUITING

    Delhi, New Delhi, 110029, India

  • Amrita Institute Of Medical Sciences & Research Centre

    RECRUITING

    Kochi, Kerala, 682041, India

  • Ankara Etlik Şehir Hastanesi-Göğüs Hastalıkları

    RECRUITING

    Yenimahalle / Ankara, 06170, Turkey (Türkiye)

  • Apollo Multispeciality Hospital, Kolkata

    RECRUITING

    Kolkata, West Bengal, 700054, India

  • Asian Kidney Hospital And Medical Centre

    RECRUITING

    Nagpur, Maharashtra, 440010, India

  • Asthma Bhawan

    RECRUITING

    Jaipur, 302039, India

  • Bhaktivedanta Hospital & Research Institute

    RECRUITING

    Mumbai, Maharashtra, 401107, India

  • Biorhythms Center for Integrative Sleep Medicine

    RECRUITING

    El Paso, Texas, 79912, United States

  • Bogan Sleep Consultants, LLC

    RECRUITING

    Columbia, South Carolina, 29201, United States

  • Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları

    RECRUITING

    Yıldırım/Bursa, 16310, Turkey (Türkiye)

  • CTI Clinical Research Center

    RECRUITING

    Cincinnati, Ohio, 45212, United States

  • Cathay General Hospital

    RECRUITING

    Taipei, 106, Taiwan

  • Chang Gung Memorial Hospital, Linkou

    RECRUITING

    Taoyuan, 333, Taiwan

  • Chatani NeuroSleep Clinic_Neurology

    RECRUITING

    Hiroshima, 730-0051, Japan

  • Chicago Research Center, Inc

    RECRUITING

    Chicago, Illinois, 60634, United States

  • Chutoen General Medical Center_Neurology

    RECRUITING

    Shizuoka, 436-8555, Japan

  • Clinical Research Associates of Central PA, LLC

    NOT_YET_RECRUITING

    DuBois, Pennsylvania, 15801, United States

  • DM Clinical

    RECRUITING

    Bradenton, Florida, 34209, United States

  • Dignity Health, Mercy Gilbert

    RECRUITING

    Gilbert, Arizona, 85297, United States

  • Ditmanson Medical Foundation Chia-Yi Christian Hospital

    NOT_YET_RECRUITING

    Chiayi City, 600, Taiwan

  • ETG Warszawa Sp. z o.o.

    RECRUITING

    Warsaw, 02-677, Poland

  • Epic Medical Research

    RECRUITING

    DeSoto, Texas, 75115, United States

  • Essence MD Research

    RECRUITING

    Naples, Florida, 34102, United States

  • Fukuoka University Hospital_Respiratory Medicine

    RECRUITING

    Fukuoka, 814-0180, Japan

  • Government Siddhartha Medical College & Government General Hospital, Vijayawada

    RECRUITING

    Vijayawada, Andhra Pradesh, 520008, India

  • Guntur Government medical College

    COMPLETED

    Guntur, Andhra Pradesh, 522004,, India

  • Gyncentrum Sp. z o. o.

    RECRUITING

    Warsaw, 00-124, Poland

  • H.U. Quirónsalud Madrid

    RECRUITING

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hitit Üniversitesi Çorum Erol Olçok Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları

    RECRUITING

    Merkez/Çorum, 19040, Turkey (Türkiye)

  • Hospital Ramón y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Univ. de Santa María de Lleida

    RECRUITING

    Lleida, 25198, Spain

  • Hospital Universitario San Pedro

    RECRUITING

    Logroño, 26006, Spain

  • Hospital Universitario de Araba

    RECRUITING

    Vitoria-Gasteiz, 01004, Spain

  • Hospital Universitario de Guadalajara

    RECRUITING

    Guadalajara, Castille-La Mancha, 19002, Spain

  • Hospital Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Vithas Sevilla

    RECRUITING

    Castilleja de la Cuesta, 41950, Spain

  • Houston Pulm Med Res Network

    RECRUITING

    Houston, Texas, 77089, United States

  • Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

    RECRUITING

    Münster, 48145, Germany

  • Instituto de Investigaciones del Sueño

    RECRUITING

    Madrid, 28036, Spain

  • Juntendo University Hospital_Cardiovascular Biology And Medicine

    RECRUITING

    Tokyo, 113-8431, Japan

  • KKR Sappro Medical Center_Respiratory Medicine

    RECRUITING

    Sapporo-shi, Hokkaido, 062-0931, Japan

  • Krakowski Szpital Specjalistyczny im. Jana Pawla II

    COMPLETED

    Krakow, 31-202, Poland

  • Kuwamizu Hospital_Internal Medicine

    RECRUITING

    Kumamoto, 862-0954, Japan

  • Lillestol Research LLC

    RECRUITING

    Fargo, North Dakota, 58104, United States

  • Mater Research - RIO Clinical Trials Unit

    NOT_YET_RECRUITING

    South Brisbane, Queensland, 4101, Australia

  • Midland Healthcare & Research Center

    RECRUITING

    Lucknow, Uttar Pradesh, 226006, India

  • Nakamura Clinic_Pulmonology

    RECRUITING

    Okinawa, 901-2132, Japan

  • Nanfang Hospital, Southern Medical University-Department of Psychiatry and Psychology

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, 510515, China

  • National Institute Of Tuberculosis And Lung Diseases - Instytut Gruźlicy i Chorób Płuc

    RECRUITING

    Warsaw, 01-138, Poland

  • NeuroTrials Research, Inc.

    RECRUITING

    Atlanta, Georgia, 30328, United States

  • Nightingale Research Adelaide

    RECRUITING

    Adelaide, South Australia, 5000, Australia

  • Osaka Kaisei Hospital_Sleep Medical Center

    RECRUITING

    Osaka, 532-0003, Japan

  • PANSTWOWY INSTYTUT MEDYCZNY MSWiA

    RECRUITING

    Warsaw, 02-507, Poland

  • Palm Beach Research Center

    RECRUITING

    West Palm Beach, Florida, 33409, United States

  • Peking University People's Hospital-Endocrinology

    RECRUITING

    Beijing, Beijing Municipality, 100044, China

  • Penta Hospitals Badania Kliniczne Sp. z o.o.

    RECRUITING

    Gdansk, 80-546, Poland

  • Physicians Research Associates

    RECRUITING

    Lawrenceville, Georgia, 30046, United States

  • Rainier Clin Res Ctr Inc

    RECRUITING

    Renton, Washington, 98057, United States

  • Rajarajeswari Medical College and Hospital

    RECRUITING

    Bengaluru, Karnataka, 560074, India

  • Seattle Clinical Research Center

    RECRUITING

    Seattle, Washington, 98104, United States

  • Shenzhen People's Hospital-Sleep Medicine Department

    NOT_YET_RECRUITING

    Shenzhen, Guangdong, 518020, China

  • Siteworks GmbH - Prüfzentrum Schleswig | RespiRatio

    RECRUITING

    Schleswig, 24837, Germany

  • Siteworks GmbH Bochum

    RECRUITING

    Bochum, 44787, Germany

  • Siteworks GmbH Hannover

    RECRUITING

    Hanover, 30449, Germany

  • Siteworks GmbH Karlsruhe

    RECRUITING

    Karlsruhe, 76137, Germany

  • Sleep Therapy Research Center

    RECRUITING

    San Antonio, Texas, 78229, United States

  • T.C. Sağlık Bakanlığı Alaaddin Keykubat Üniversitesi Alanya Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları

    RECRUITING

    Alanya/ Antalya, 07400, Turkey (Türkiye)

  • Taipei Medical University Hospital

    RECRUITING

    Taipei, 110, Taiwan

  • Taipei Municipal Wan Fang Hospital_Division of Otorhinolaryngology

    RECRUITING

    Taipei, 116, Taiwan

  • The First Affiliated Hospital of Henan University of Science and Technology-Endocrinology

    NOT_YET_RECRUITING

    Luoyang, Henan, 471003, China

  • The Second Affiliated Hospital of Nanjing Medical University-Endocrinology

    RECRUITING

    Nanjing, Jiangsu, 210011, China

  • Tianjin Medical University General Hospital-Respiratory

    NOT_YET_RECRUITING

    Tianjin, Tianjin Municipality, 300052, China

  • Tokyo Tenshi Hospital_Internal medicine

    RECRUITING

    Tokyo, 193-0811, Japan

  • Tokyo-Eki Center-building Clinic_Internal Medicine

    RECRUITING

    Tokyo, 103-0027, Japan

  • Tricoastal Sleep Center

    RECRUITING

    Sugar Land, Texas, 77478, United States

  • University of Sunshine Coast - Vitality Village

    RECRUITING

    Birtinya, Queensland, 4575, Australia

  • University of Western Australia - Centre for Sleep Science

    RECRUITING

    Crawley, Western Australia, 6009, Australia

  • Uniwersytecki Szpital Kliniczny W Poznaniu

    RECRUITING

    Poznan, 60-569, Poland

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gdansk, 80-214, Poland

  • Vardhaman Mahavir Medical College & Safdarjung Hospital

    NOT_YET_RECRUITING

    New Delhi, National Capital Territory of Delhi, 110029, India

  • Weil Cornell Medicine

    RECRUITING

    New York, New York, 10021, United States

  • Wendisch - Dahl Hamburg - DZHW

    RECRUITING

    Hamburg, 22607, Germany

  • Woolcock Institute

    RECRUITING

    Macquarie Park, New South Wales, 2113, Australia

  • Yashoda Hospital

    COMPLETED

    Hyderabad, Telangana, 500084, India

  • Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi

    RECRUITING

    Zeytinburnu/İstanbul, 34020, Turkey (Türkiye)

  • İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi- Göğüs Hastalıkları

    RECRUITING

    Merkez/Battalgazi/Malatya, 44280, Turkey (Türkiye)

  • İstanbul İl Sağlik Müdürlüğü Süreyyapaşa Göğüs Hastaliklari Ve Göğüs Cerrahisi Eğitim Ve Araştirma Hastanesi

    RECRUITING

    Maltepe/İstanbull, 34843, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.