OVERWEIGHT

This study tests a family-based weight management program for youth with type 1 diabetes who are overweight or obese, along with one of their parents who is also overweight. The program is adapted from a proven treatment and delivered in a hybrid format. The goal is to help both …

This study tests a once-weekly injection called retatrutide for weight loss in people with obesity or overweight who do not have diabetes. About 2,335 participants will receive the drug or a placebo for up to 89 weeks. The study also looks at how the drug affects knee osteoarthri…

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 adults who do not have diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if the treatm…

This study tests an investigational drug called taldefgrobep alfa to help adults with overweight or obesity lose weight. About 150 participants receive either the drug or a placebo injection weekly for 24 weeks, with an option to continue in an open-label extension. The main goal…

This large Phase 3 trial tests a once-daily tablet called orforglipron against a placebo in 1,200 adults who are obese or overweight, some of whom also have type 2 diabetes. The study is split into two parts: one for people without diabetes and one for those with diabetes. The go…

This study tests a new weekly injection called petrelintide in 221 adults who are overweight or obese and have type 2 diabetes. The goal is to see if it helps with weight loss and blood sugar control compared to a placebo. Participants must be on stable diabetes medication like m…

This study tests an oral medication called orforglipron, taken once daily, to help adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea. About 3,100 participants will receive either the drug or a placebo for 72 weeks, w…

This study tests a weekly medicine called tirzepatide in adults with type 1 diabetes who are also overweight or have obesity. The goal is to see if it helps control blood sugar and reduce weight better than a placebo. About 465 people will take part for around 20 months, and all …

This study tests whether adding an experimental drug (RO7204239) to an existing weight-loss medication (tirzepatide) helps people with obesity or overweight lose more weight over 48 weeks. About 285 adults who have at least one weight-related health issue (like high blood pressur…

This study tests a culturally tailored support program for 300 Chinese and Korean American caregivers of relatives with dementia. The program combines counseling with online peer support groups to reduce stress, depression, and health risks like diabetes and heart disease. Resear…

This study tests whether a new weekly injection called IBI362 works better than the existing drug semaglutide for weight loss and reducing liver fat in overweight or obese Chinese adults with metabolic fatty liver disease. About 479 participants will receive either drug for 48 we…

This study tests a new tablet called VCT220 to help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or a placebo pill once daily for 12 months. The main goal is to see how much weight they lose and if they achieve at least a …

This study tests a program called TOTAL that uses an educational video and motivational coaching sessions over video calls to help veterans with obesity start and stick with proven treatments like the MOVE! weight management program, weight loss medications, or bariatric surgery.…

This study looks at whether video consultations can help overweight children aged 9-11 lose weight as effectively as in-person hospital visits. After an initial checkup, children are randomly assigned to continue treatment either at the clinic or via video calls. The goal is to s…

This study tests two drugs, LY3841136 and tirzepatide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 350 people will take part for 64 weeks. The goal is to see if these treatments are safe and effective for chronic weight mana…

This study tests a once-weekly medicine called retatrutide in about 1000 adults with type 2 diabetes who are overweight or have obesity. The goal is to see if it helps with weight loss and, for a subset with sleep apnea, improves breathing during sleep. Participants receive eithe…

This study tests a new weekly pill, VRB-101, to help people with obesity or overweight who also have weight-related health problems lose weight. About 206 participants will receive either the drug or a placebo. The main goal is to see how much weight they lose over the treatment …

This study tests a once-daily pill called orforglipron against a placebo in 600 adults with obesity or overweight who also have type 2 diabetes. The goal is to see if the pill helps lower blood sugar and body weight over about 18 months. Participants must have a BMI of 25 or high…

This study aimed to see if a probiotic protein drink could help manage weight in children aged 2 to 5 who were gaining weight too quickly. It planned to compare the drink to a placebo over three months. However, the study was withdrawn before any children were enrolled, so no res…

This study tests if tirzepatide, a once-weekly injection, is safe and effective for adults with type 1 diabetes who are overweight or have obesity. About 905 participants will receive either tirzepatide or a placebo for 49 weeks. The main goals are to see if it improves blood sug…

This early-stage study tests the safety of an experimental drug called LY3537031 in 302 people who are overweight, obese, or healthy. Researchers will monitor side effects, measure how the drug moves through the body, and track weight changes over about 49 weeks. The goal is to s…

This study tests an experimental medicine called cagrilintide to help people with overweight or obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and ho…

This study tests a new medicine, cagrilintide, to help people with obesity or overweight lose weight. About 300 adults will receive either the drug or a placebo for around 18 months. The main goals are to see how much weight they lose and how many achieve at least a 5% reduction.…

This study tests whether a daily avocado supplement (Metavo) can help overweight adults manage their weight and blood sugar. Sixty participants will take either the supplement or a placebo for 16 weeks, while researchers track changes in body weight, blood glucose, and other heal…

This study aimed to test two drugs, bimagrumab and tirzepatide, alone or together, for helping adults with obesity or overweight and type 2 diabetes lose weight. Participants would have taken injections for about 13 months. However, the study was withdrawn before enrolling anyone…

This study tests a new once-weekly medicine called NNC0662-0419 in 224 adults with overweight or obesity. Participants receive either the active drug or a placebo to see if it is safe and helps with weight loss. The main goals are to check for side effects and measure changes in …

This large phase 3 study is testing whether tirzepatide, a medication for weight management, can reduce the risk of serious health events like heart attacks, strokes, and death in over 15,000 adults with obesity or overweight. Participants either have existing heart disease or ar…

This study tests whether two drugs, bimagrumab and tirzepatide, work better together than alone for weight loss in adults with obesity or overweight who do not have type 2 diabetes. About 240 participants will take the drugs or a placebo for 70 weeks. The main goal is to see how …

This study looks at a program called 010 Fit'R for overweight children aged 4 to 12 in Rotterdam. The program helps kids and their parents make lasting changes to eating, physical activity, and motor skills. Researchers will measure things like quality of life, body mass index (B…

This study tests whether two plant-based supplements can help manage blood sugar in adults with prediabetes who are overweight. Over 12 weeks, 87 participants will take either a polyphenol-rich extract, that same extract plus white kidney bean and minerals, or a placebo. The goal…

This study was designed to test a new combination of two drugs (sibutramine and topiramate) for helping overweight adults with conditions like high blood pressure or diabetes lose weight. It was a large, carefully controlled trial that planned to compare the new drug against a pl…

This study tests a once-daily tablet called orforglipron to see if it helps people with obesity or overweight lose weight. About 600 adults who do not have diabetes will take either the drug or a placebo for around 18 months. The main goal is to measure how much weight they lose …

This early-stage study tests whether the drug RO7204239 can improve how the body uses insulin in people with type 2 diabetes who are also overweight or obese. About 30 participants will receive either the drug or a placebo for 24 weeks. The main goal is to measure changes in insu…

This study tests whether tirzepatide, a medication for weight and diabetes management, can improve kidney health in 140 adults with overweight or obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat …

This study looks at whether intermittent fasting can help overweight veterans aged 50-75 keep weight off after losing it. About 175 veterans will try this eating pattern to see if it prevents weight regain. The goal is to find a simple, low-cost way to manage weight and reduce he…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which program works best to improve waist size and overall health, whi…

This study tests whether a mobile app for parents can help prevent overweight and obesity in school children aged 5-11 in Mexico City. About 743 children from four schools will take part, with some families using the app and others not. The app gives tips on healthy eating and ph…

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese women at high risk for breast cancer lose weight and potentially lower their cancer risk. About 51 participants will learn weight-loss strategies and how to recognize tr…

This study looks at whether eating almonds twice a day for 12 weeks can improve physical function, aerobic capacity, and activity levels in overweight but active adults aged 50-59. Participants will compare almond snacks to a calorie-matched control snack. The goal is to see if a…

This pilot study is testing a new exercise-focused group for people who are overweight or have obesity. The goal is to see if the group helps increase physical activity without raising the risk of unhealthy eating behaviors. The study will enroll 12 adults who have had weight los…

This study looks at whether eating only during an 8-hour window, either early or late in the day, helps overweight adults lose weight and improve health. Researchers will track changes in weight, body mass index, and blood sugar levels. The goal is to find out which eating schedu…

This early-stage study tests a new injectable medicine for people who are overweight or have obesity. The main goal is to check if the medicine is safe and how the body handles it. About 63 participants will receive either the study drug or a placebo. This is a phase 1 trial, so …

This early-stage study compares how two different injection versions of the experimental drug maridebart cafraglutide are absorbed by the body. About 348 adults with overweight or obesity will receive a single dose of one version. The main goal is to measure drug levels in the bl…

This observational study follows 728 pregnant women who took Wegovy for weight management and compares their babies' health to those not exposed. Researchers will track birth defects and infant development through the first year of life. The goal is to understand if Wegovy poses …

This study looks at whether two types of olive oil can change risk factors for heart disease, such as cholesterol levels, inflammation, and gene activity. Researchers will test blood samples from 44 healthy adults of different body weights after they consume the oils. The goal is…

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This study uses insurance records to compare health outcomes for mothers and babies when Wegovy is taken during pregnancy versus when it is not. Researchers will look at birth defects and other issues in about 1,139 women aged 15-45. The goal is to help patients and doctors make …

This early-stage study looks at how a single dose of an experimental medicine (PF-08653944) is absorbed when injected into the abdomen, thigh, or upper arm. It involves 54 overweight or obese adults who are otherwise healthy. The goal is to understand safety and how the body proc…

This early-stage study checks whether maridebart cafraglutide, a drug for overweight or obesity, changes the heart's electrical activity. About 81 adults aged 18-60 will receive the drug, a placebo, or a positive control to compare effects. The main goal is to see if the drug cau…

This study looks at how pretzels made with safflower oil and soy affect energy use in overweight postmenopausal women with metabolic syndrome. Twenty women will eat different pretzels for one month each to see how their bodies process them. The goal is to learn if these snacks ca…

This study looks at how long you need to fast and how stopping the diabetes drug tirzepatide changes the amount of food and liquid left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 adults with type 2 diabetes or obesity. The goal i…

This study looks at whether improving metabolic health through a 3-month lifestyle or blood sugar program can change epigenetic marks in the sperm of overweight men with type 1 or type 2 diabetes. Researchers will measure sperm concentration and DNA methylation patterns before an…

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study looks at medical records from 60,000 people with type 2 diabetes and obesity to compare three drugs (dulaglutide, semaglutide, and tirzepatide) against an older drug (sitagliptin). The goal is to see which one is best at preventing heart attacks, strokes, and death. Th…

This study tests whether a patient navigator (a personal guide) can help adults with overweight or obesity choose and stick with a weight loss program. 68 participants will work with a navigator for 12 months. The goal is to see if this approach improves weight loss and program e…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, testing two different support strategies. The goal is to see which approach gets more women …